Targeting the epichaperome as an effective precision medicine approach in a novel PML-SYK fusion acute myeloid leukemia

Targeting the epichaperome as an effective precision medicine approach in a novel PML-SYK fusion acute myeloid leukemia

Abstract The epichaperome is a new cancer target composed of hyperconnected networks of chaperome members that facilitate cell survival. Cancers with an altered chaperone configuration may be susceptible to epichaperome inhibitors. We developed a flow cytometry-based assay for evaluation and monitor...

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Autores principales: Mayumi Sugita, David C. Wilkes, Rohan Bareja, Kenneth W. Eng, Sarah Nataraj, Reyna A. Jimenez-Flores, LunBiao Yan, Jeanne Pauline De Leon, Jaclyn A. Croyle, Justin Kaner, Swathi Merugu, Sahil Sharma, Theresa Y. MacDonald, Zohal Noorzad, Palak Panchal, Danielle Pancirer, Shuhua Cheng, Jenny Z. Xiang, Luke Olson, Koen Van Besien, David S. Rickman, Susan Mathew, Wayne Tam, Mark A. Rubin, Himisha Beltran, Andrea Sboner, Duane C. Hassane, Gabriela Chiosis, Olivier Elemento, Gail J. Roboz, Juan Miguel Mosquera, Monica L. Guzman
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Acceso en línea:https://doaj.org/article/9b26f08bf6d444edb5f3140c7fcddf4c
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