Stem Cell Therapy for Burns: Story so Far

Najath Abdul Kareem,1 Ayesha Aijaz,1 Marc G Jeschke1– 4 1Sunnybrook Research Institute, Toronto, ON, Canada; 2Department of Surgery, Division of Plastic Surgery, University of Toronto, Toronto, ON, Canada; 3Department of Immunology, University of Toronto, Toronto, ON, Canada; 4Ross Tilley Burn Centr...

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Autores principales:	Abdul Kareem N, Aijaz A, Jeschke MG
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	stem cells burn injury exosomes conditioned media wound healing Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/9b27075e35e146b3aceaeafd97f1110d
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spelling	oai:doaj.org-article:9b27075e35e146b3aceaeafd97f1110d2021-12-02T15:12:56ZStem Cell Therapy for Burns: Story so Far1177-5491https://doaj.org/article/9b27075e35e146b3aceaeafd97f1110d2021-08-01T00:00:00Zhttps://www.dovepress.com/stem-cell-therapy-for-burns-story-so-far-peer-reviewed-fulltext-article-BTThttps://doaj.org/toc/1177-5491Najath Abdul Kareem,1 Ayesha Aijaz,1 Marc G Jeschke1– 4 1Sunnybrook Research Institute, Toronto, ON, Canada; 2Department of Surgery, Division of Plastic Surgery, University of Toronto, Toronto, ON, Canada; 3Department of Immunology, University of Toronto, Toronto, ON, Canada; 4Ross Tilley Burn Centre, Sunnybrook Health Sciences Centre, Toronto, ON, CanadaCorrespondence: Marc G JeschkeRoss Tilley Burn Centre, Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Rm D704, Toronto, ON, M4N 3M5, CanadaTel +1 416-480-6703Fax +1 416-480-6763Email marc.jeschke@sunnybrook.caAbstract: Burn injuries affect approximately 11 million people annually, with fatalities amounting up to 180,000. Burn injuries constitute a global health issue associated with high morbidity and mortality. Recent years have seen advancements in regenerative medicine for burn wound healing encompassing stem cells and stem cell-derived products such as exosomes and conditioned media with promising results compared to current treatment approaches. Sources of stem cells used for treatment vary ranging from hair follicle stem cells, embryonic stem cells, umbilical cord stem cells, to mesenchymal stem cells, such as adipose-derived mesenchymal stem cells, bone marrow-derived mesenchymal stem cells, and even stem cells harvested from discarded burn tissue. Stem cells utilize various pathways for wound healing, such as PI3/AKT pathway, WNT-β catenin pathway, TGF-β pathway, Notch and Hedgehog signaling pathway. Due to the paracrine signaling mechanism of stem cells, exosomes and conditioned media derived from stem cells have also been utilized in burn wound therapy. As exosomes and conditioned media are cell-free therapy and contain various biomolecules that facilitate wound healing, they are gaining popularity as an alternative treatment strategy with significant improvement in outcomes. The treatment is provided either as direct injections or embedded in a natural/artificial scaffold. This paper reviews in detail the different sources of stem cells, stem cell-derived products, their efficacy in burn wound repair, associated signaling pathways and modes of delivery for wound healing.Keywords: stem cells, burn injury, exosomes, conditioned media, wound healingAbdul Kareem NAijaz AJeschke MGDove Medical Pressarticlestem cellsburn injuryexosomesconditioned mediawound healingMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol Volume 15, Pp 379-397 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	stem cells burn injury exosomes conditioned media wound healing Medicine (General) R5-920
spellingShingle	stem cells burn injury exosomes conditioned media wound healing Medicine (General) R5-920 Abdul Kareem N Aijaz A Jeschke MG Stem Cell Therapy for Burns: Story so Far
description	Najath Abdul Kareem,1 Ayesha Aijaz,1 Marc G Jeschke1– 4 1Sunnybrook Research Institute, Toronto, ON, Canada; 2Department of Surgery, Division of Plastic Surgery, University of Toronto, Toronto, ON, Canada; 3Department of Immunology, University of Toronto, Toronto, ON, Canada; 4Ross Tilley Burn Centre, Sunnybrook Health Sciences Centre, Toronto, ON, CanadaCorrespondence: Marc G JeschkeRoss Tilley Burn Centre, Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Rm D704, Toronto, ON, M4N 3M5, CanadaTel +1 416-480-6703Fax +1 416-480-6763Email marc.jeschke@sunnybrook.caAbstract: Burn injuries affect approximately 11 million people annually, with fatalities amounting up to 180,000. Burn injuries constitute a global health issue associated with high morbidity and mortality. Recent years have seen advancements in regenerative medicine for burn wound healing encompassing stem cells and stem cell-derived products such as exosomes and conditioned media with promising results compared to current treatment approaches. Sources of stem cells used for treatment vary ranging from hair follicle stem cells, embryonic stem cells, umbilical cord stem cells, to mesenchymal stem cells, such as adipose-derived mesenchymal stem cells, bone marrow-derived mesenchymal stem cells, and even stem cells harvested from discarded burn tissue. Stem cells utilize various pathways for wound healing, such as PI3/AKT pathway, WNT-β catenin pathway, TGF-β pathway, Notch and Hedgehog signaling pathway. Due to the paracrine signaling mechanism of stem cells, exosomes and conditioned media derived from stem cells have also been utilized in burn wound therapy. As exosomes and conditioned media are cell-free therapy and contain various biomolecules that facilitate wound healing, they are gaining popularity as an alternative treatment strategy with significant improvement in outcomes. The treatment is provided either as direct injections or embedded in a natural/artificial scaffold. This paper reviews in detail the different sources of stem cells, stem cell-derived products, their efficacy in burn wound repair, associated signaling pathways and modes of delivery for wound healing.Keywords: stem cells, burn injury, exosomes, conditioned media, wound healing
format	article
author	Abdul Kareem N Aijaz A Jeschke MG
author_facet	Abdul Kareem N Aijaz A Jeschke MG
author_sort	Abdul Kareem N
title	Stem Cell Therapy for Burns: Story so Far
title_short	Stem Cell Therapy for Burns: Story so Far
title_full	Stem Cell Therapy for Burns: Story so Far
title_fullStr	Stem Cell Therapy for Burns: Story so Far
title_full_unstemmed	Stem Cell Therapy for Burns: Story so Far
title_sort	stem cell therapy for burns: story so far
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/9b27075e35e146b3aceaeafd97f1110d
work_keys_str_mv	AT abdulkareemn stemcelltherapyforburnsstorysofar AT aijaza stemcelltherapyforburnsstorysofar AT jeschkemg stemcelltherapyforburnsstorysofar
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Stem Cell Therapy for Burns: Story so Far

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