Hedgehog signaling in cancer stem cells: a focus on hematological cancers

Victoria Campbell, Mhairi Copland Paul O'Gorman Leukaemia Research Centre, Institute of Cancer Sciences, College of Medical, Veterninary and Life Sciences, University of Glasgow, Glasgow, UK Abstract: The stem cell paradigm was first demonstrated in hematopoietic stem cells. Whilst classic...

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Autores principales:	Campbell V, Copl, M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Cytology QH573-671
Acceso en línea:	https://doaj.org/article/9b28150a9a5d463e892c201c94070d82
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spelling	oai:doaj.org-article:9b28150a9a5d463e892c201c94070d822021-12-02T05:34:05ZHedgehog signaling in cancer stem cells: a focus on hematological cancers1178-6957https://doaj.org/article/9b28150a9a5d463e892c201c94070d822015-01-01T00:00:00Zhttp://www.dovepress.com/stem-cells-and-cloning-advances-and-applications-peer-reviewed-article-SCCAAhttps://doaj.org/toc/1178-6957 Victoria Campbell, Mhairi Copland Paul O'Gorman Leukaemia Research Centre, Institute of Cancer Sciences, College of Medical, Veterninary and Life Sciences, University of Glasgow, Glasgow, UK Abstract: The stem cell paradigm was first demonstrated in hematopoietic stem cells. Whilst classically it was cytokines and chemokines which were believed to control stem cell fate, more recently it has become apparent that the stem cell niche and highly conserved embryonic pathways play a key role in governing stem cell behavior. One of these pathways, the hedgehog signaling pathway, found in all organisms, is vitally important in embryogenesis, performing the function of patterning through early stages of development, and in adulthood, through the control of somatic stem cell numbers. In addition to these roles in health however, it has been found to be deregulated in a number of solid and hematological malignancies, components of the hedgehog pathway being associated with a poor prognosis. Further, these components represent viable therapeutic targets, with inhibition from a drug development perspective being readily achieved, making the hedgehog pathway an attractive potential therapeutic target. However, although the concept of cancer stem cells is well established, how these cells arise and the factors which influence their behavior are not yet fully understood. The role of the hedgehog signaling pathway and its potential as a therapeutic target in hematological malignancies is the focus of this review. Keywords: hedgehog signaling pathway, stem cell, cancer stem cell, hematopoiesis, myeloid, lymphoidCampbell VCoplMDove Medical PressarticleCytologyQH573-671ENStem Cells and Cloning: Advances and Applications, Vol 2015, Iss default, Pp 27-38 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 Campbell V Copl M Hedgehog signaling in cancer stem cells: a focus on hematological cancers
description	Victoria Campbell, Mhairi Copland Paul O'Gorman Leukaemia Research Centre, Institute of Cancer Sciences, College of Medical, Veterninary and Life Sciences, University of Glasgow, Glasgow, UK Abstract: The stem cell paradigm was first demonstrated in hematopoietic stem cells. Whilst classically it was cytokines and chemokines which were believed to control stem cell fate, more recently it has become apparent that the stem cell niche and highly conserved embryonic pathways play a key role in governing stem cell behavior. One of these pathways, the hedgehog signaling pathway, found in all organisms, is vitally important in embryogenesis, performing the function of patterning through early stages of development, and in adulthood, through the control of somatic stem cell numbers. In addition to these roles in health however, it has been found to be deregulated in a number of solid and hematological malignancies, components of the hedgehog pathway being associated with a poor prognosis. Further, these components represent viable therapeutic targets, with inhibition from a drug development perspective being readily achieved, making the hedgehog pathway an attractive potential therapeutic target. However, although the concept of cancer stem cells is well established, how these cells arise and the factors which influence their behavior are not yet fully understood. The role of the hedgehog signaling pathway and its potential as a therapeutic target in hematological malignancies is the focus of this review. Keywords: hedgehog signaling pathway, stem cell, cancer stem cell, hematopoiesis, myeloid, lymphoid
format	article
author	Campbell V Copl M
author_facet	Campbell V Copl M
author_sort	Campbell V
title	Hedgehog signaling in cancer stem cells: a focus on hematological cancers
title_short	Hedgehog signaling in cancer stem cells: a focus on hematological cancers
title_full	Hedgehog signaling in cancer stem cells: a focus on hematological cancers
title_fullStr	Hedgehog signaling in cancer stem cells: a focus on hematological cancers
title_full_unstemmed	Hedgehog signaling in cancer stem cells: a focus on hematological cancers
title_sort	hedgehog signaling in cancer stem cells: a focus on hematological cancers
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/9b28150a9a5d463e892c201c94070d82
work_keys_str_mv	AT campbellv hedgehogsignalingincancerstemcellsafocusonhematologicalcancers AT copl hedgehogsignalingincancerstemcellsafocusonhematologicalcancers AT m hedgehogsignalingincancerstemcellsafocusonhematologicalcancers
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Hedgehog signaling in cancer stem cells: a focus on hematological cancers

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