Behavior of hospitalized severe influenza cases according to the outcome variable in Catalonia, Spain, during the 2017–2018 season

Abstract Influenza is an important cause of severe illness and death among patients with underlying medical conditions and in the elderly. The aim of this study was to investigate factors associated with ICU admission and death in patients hospitalized with severe laboratory-confirmed influenza duri...

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Autores principales:	Núria Soldevila, Lesly Acosta, Ana Martínez, Pere Godoy, Núria Torner, Cristina Rius, Mireia Jané, Angela Domínguez, the Surveillance of Hospitalized Cases of Severe Influenza in Catalonia Working Group
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9b29e6756cfc4ff0bcf398da5a472e17
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spelling	oai:doaj.org-article:9b29e6756cfc4ff0bcf398da5a472e172021-12-02T16:31:58ZBehavior of hospitalized severe influenza cases according to the outcome variable in Catalonia, Spain, during the 2017–2018 season10.1038/s41598-021-92895-52045-2322https://doaj.org/article/9b29e6756cfc4ff0bcf398da5a472e172021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92895-5https://doaj.org/toc/2045-2322Abstract Influenza is an important cause of severe illness and death among patients with underlying medical conditions and in the elderly. The aim of this study was to investigate factors associated with ICU admission and death in patients hospitalized with severe laboratory-confirmed influenza during the 2017–2018 season in Catalonia. An observational epidemiological case-to-case study was carried out. Reported cases of severe laboratory-confirmed influenza requiring hospitalization in 2017–2018 influenza season were included. Mixed-effects regression analysis was used to estimate the factors associated with ICU admission and death. A total of 1306 cases of hospitalized severe influenza cases were included, of whom 175 (13.4%) died and 217 (16.6%) were ICU admitted. Age 65–74 years and ≥ 75 years and having ≥ 2 comorbidities were positively associated with death (aOR 3.19; 95%CI 1.19–8.50, aOR 6.95, 95%CI 2.76–1.80 and aOR 1.99; 95%CI 1.12–3.52, respectively). Neuraminidase inhibitor treatment and pneumonia were negatively associated with death. The 65–74 years and ≥ 75 years age groups were negatively associated with ICU admission (aOR 0.41; 95%CI 0.23–0.74 and aOR 0.30; 95%CI 0.17–0.53, respectively). A factor positively associated with ICU admission was neuraminidase inhibitor treatment. Our results support the need to investigate the worst outcomes of hospitalized severe cases, distinguishing between death and ICU admission.Núria SoldevilaLesly AcostaAna MartínezPere GodoyNúria TornerCristina RiusMireia JanéAngela Domínguezthe Surveillance of Hospitalized Cases of Severe Influenza in Catalonia Working GroupNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Núria Soldevila Lesly Acosta Ana Martínez Pere Godoy Núria Torner Cristina Rius Mireia Jané Angela Domínguez the Surveillance of Hospitalized Cases of Severe Influenza in Catalonia Working Group Behavior of hospitalized severe influenza cases according to the outcome variable in Catalonia, Spain, during the 2017–2018 season
description	Abstract Influenza is an important cause of severe illness and death among patients with underlying medical conditions and in the elderly. The aim of this study was to investigate factors associated with ICU admission and death in patients hospitalized with severe laboratory-confirmed influenza during the 2017–2018 season in Catalonia. An observational epidemiological case-to-case study was carried out. Reported cases of severe laboratory-confirmed influenza requiring hospitalization in 2017–2018 influenza season were included. Mixed-effects regression analysis was used to estimate the factors associated with ICU admission and death. A total of 1306 cases of hospitalized severe influenza cases were included, of whom 175 (13.4%) died and 217 (16.6%) were ICU admitted. Age 65–74 years and ≥ 75 years and having ≥ 2 comorbidities were positively associated with death (aOR 3.19; 95%CI 1.19–8.50, aOR 6.95, 95%CI 2.76–1.80 and aOR 1.99; 95%CI 1.12–3.52, respectively). Neuraminidase inhibitor treatment and pneumonia were negatively associated with death. The 65–74 years and ≥ 75 years age groups were negatively associated with ICU admission (aOR 0.41; 95%CI 0.23–0.74 and aOR 0.30; 95%CI 0.17–0.53, respectively). A factor positively associated with ICU admission was neuraminidase inhibitor treatment. Our results support the need to investigate the worst outcomes of hospitalized severe cases, distinguishing between death and ICU admission.
format	article
author	Núria Soldevila Lesly Acosta Ana Martínez Pere Godoy Núria Torner Cristina Rius Mireia Jané Angela Domínguez the Surveillance of Hospitalized Cases of Severe Influenza in Catalonia Working Group
author_facet	Núria Soldevila Lesly Acosta Ana Martínez Pere Godoy Núria Torner Cristina Rius Mireia Jané Angela Domínguez the Surveillance of Hospitalized Cases of Severe Influenza in Catalonia Working Group
author_sort	Núria Soldevila
title	Behavior of hospitalized severe influenza cases according to the outcome variable in Catalonia, Spain, during the 2017–2018 season
title_short	Behavior of hospitalized severe influenza cases according to the outcome variable in Catalonia, Spain, during the 2017–2018 season
title_full	Behavior of hospitalized severe influenza cases according to the outcome variable in Catalonia, Spain, during the 2017–2018 season
title_fullStr	Behavior of hospitalized severe influenza cases according to the outcome variable in Catalonia, Spain, during the 2017–2018 season
title_full_unstemmed	Behavior of hospitalized severe influenza cases according to the outcome variable in Catalonia, Spain, during the 2017–2018 season
title_sort	behavior of hospitalized severe influenza cases according to the outcome variable in catalonia, spain, during the 2017–2018 season
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9b29e6756cfc4ff0bcf398da5a472e17
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Behavior of hospitalized severe influenza cases according to the outcome variable in Catalonia, Spain, during the 2017–2018 season

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