Localized force application reveals mechanically sensitive domains of Piezo1

Piezo ion channels transduce mechanical forces into biological signals. Here, the authors use magnetic tweezers to pull specific regions of Piezo1, identifying mechanically sensitive domains that are essential for channel activation and inactivation.

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Detalles Bibliográficos
Autores principales:	Jason Wu, Raman Goyal, Jörg Grandl
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9b2a3316a5b846f387db4b7f7d9a9f06
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spelling	oai:doaj.org-article:9b2a3316a5b846f387db4b7f7d9a9f062021-12-02T17:31:36ZLocalized force application reveals mechanically sensitive domains of Piezo110.1038/ncomms129392041-1723https://doaj.org/article/9b2a3316a5b846f387db4b7f7d9a9f062016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms12939https://doaj.org/toc/2041-1723Piezo ion channels transduce mechanical forces into biological signals. Here, the authors use magnetic tweezers to pull specific regions of Piezo1, identifying mechanically sensitive domains that are essential for channel activation and inactivation.Jason WuRaman GoyalJörg GrandlNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jason Wu Raman Goyal Jörg Grandl Localized force application reveals mechanically sensitive domains of Piezo1
description	Piezo ion channels transduce mechanical forces into biological signals. Here, the authors use magnetic tweezers to pull specific regions of Piezo1, identifying mechanically sensitive domains that are essential for channel activation and inactivation.
format	article
author	Jason Wu Raman Goyal Jörg Grandl
author_facet	Jason Wu Raman Goyal Jörg Grandl
author_sort	Jason Wu
title	Localized force application reveals mechanically sensitive domains of Piezo1
title_short	Localized force application reveals mechanically sensitive domains of Piezo1
title_full	Localized force application reveals mechanically sensitive domains of Piezo1
title_fullStr	Localized force application reveals mechanically sensitive domains of Piezo1
title_full_unstemmed	Localized force application reveals mechanically sensitive domains of Piezo1
title_sort	localized force application reveals mechanically sensitive domains of piezo1
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/9b2a3316a5b846f387db4b7f7d9a9f06
work_keys_str_mv	AT jasonwu localizedforceapplicationrevealsmechanicallysensitivedomainsofpiezo1 AT ramangoyal localizedforceapplicationrevealsmechanicallysensitivedomainsofpiezo1 AT jorggrandl localizedforceapplicationrevealsmechanicallysensitivedomainsofpiezo1
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Localized force application reveals mechanically sensitive domains of Piezo1

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