A Blueprint for Cancer-Related Inflammation and Host Innate Immunity

Both in situ and allograft models of cancer in juvenile and adult <i>Drosophila melanogaster</i> fruit flies offer a powerful means for unravelling cancer gene networks and cancer–host interactions. They can also be used as tools for cost-effective drug discovery and repurposing. Moreove...

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Autores principales:	Lucia García-López, Isabel Adrados, Dolors Ferres-Marco, Maria Dominguez
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	tumor–host interactions inflammation innate antitumor immunity diet autophagy cachexia Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/9b2ae5c1bd254a2181076031bddbb32c
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id	oai:doaj.org-article:9b2ae5c1bd254a2181076031bddbb32c
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spelling	oai:doaj.org-article:9b2ae5c1bd254a2181076031bddbb32c2021-11-25T17:12:55ZA Blueprint for Cancer-Related Inflammation and Host Innate Immunity10.3390/cells101132112073-4409https://doaj.org/article/9b2ae5c1bd254a2181076031bddbb32c2021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3211https://doaj.org/toc/2073-4409Both in situ and allograft models of cancer in juvenile and adult <i>Drosophila melanogaster</i> fruit flies offer a powerful means for unravelling cancer gene networks and cancer–host interactions. They can also be used as tools for cost-effective drug discovery and repurposing. Moreover, in situ modeling of emerging tumors makes it possible to address cancer initiating events—a black box in cancer research, tackle the innate antitumor immune responses to incipient preneoplastic cells and recurrent growing tumors, and decipher the initiation and evolution of inflammation. These studies in <i>Drosophila melanogaster</i> can serve as a blueprint for studies in more complex organisms and help in the design of mechanism-based therapies for the individualized treatment of cancer diseases in humans. This review focuses on new discoveries in <i>Drosophila</i> related to the diverse innate immune responses to cancer-related inflammation and the systemic effects that are so detrimental to the host.Lucia García-LópezIsabel AdradosDolors Ferres-MarcoMaria DominguezMDPI AGarticletumor–host interactionsinflammationinnate antitumor immunitydietautophagycachexiaBiology (General)QH301-705.5ENCells, Vol 10, Iss 3211, p 3211 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	tumor–host interactions inflammation innate antitumor immunity diet autophagy cachexia Biology (General) QH301-705.5
spellingShingle	tumor–host interactions inflammation innate antitumor immunity diet autophagy cachexia Biology (General) QH301-705.5 Lucia García-López Isabel Adrados Dolors Ferres-Marco Maria Dominguez A Blueprint for Cancer-Related Inflammation and Host Innate Immunity
description	Both in situ and allograft models of cancer in juvenile and adult <i>Drosophila melanogaster</i> fruit flies offer a powerful means for unravelling cancer gene networks and cancer–host interactions. They can also be used as tools for cost-effective drug discovery and repurposing. Moreover, in situ modeling of emerging tumors makes it possible to address cancer initiating events—a black box in cancer research, tackle the innate antitumor immune responses to incipient preneoplastic cells and recurrent growing tumors, and decipher the initiation and evolution of inflammation. These studies in <i>Drosophila melanogaster</i> can serve as a blueprint for studies in more complex organisms and help in the design of mechanism-based therapies for the individualized treatment of cancer diseases in humans. This review focuses on new discoveries in <i>Drosophila</i> related to the diverse innate immune responses to cancer-related inflammation and the systemic effects that are so detrimental to the host.
format	article
author	Lucia García-López Isabel Adrados Dolors Ferres-Marco Maria Dominguez
author_facet	Lucia García-López Isabel Adrados Dolors Ferres-Marco Maria Dominguez
author_sort	Lucia García-López
title	A Blueprint for Cancer-Related Inflammation and Host Innate Immunity
title_short	A Blueprint for Cancer-Related Inflammation and Host Innate Immunity
title_full	A Blueprint for Cancer-Related Inflammation and Host Innate Immunity
title_fullStr	A Blueprint for Cancer-Related Inflammation and Host Innate Immunity
title_full_unstemmed	A Blueprint for Cancer-Related Inflammation and Host Innate Immunity
title_sort	blueprint for cancer-related inflammation and host innate immunity
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/9b2ae5c1bd254a2181076031bddbb32c
work_keys_str_mv	AT luciagarcialopez ablueprintforcancerrelatedinflammationandhostinnateimmunity AT isabeladrados ablueprintforcancerrelatedinflammationandhostinnateimmunity AT dolorsferresmarco ablueprintforcancerrelatedinflammationandhostinnateimmunity AT mariadominguez ablueprintforcancerrelatedinflammationandhostinnateimmunity AT luciagarcialopez blueprintforcancerrelatedinflammationandhostinnateimmunity AT isabeladrados blueprintforcancerrelatedinflammationandhostinnateimmunity AT dolorsferresmarco blueprintforcancerrelatedinflammationandhostinnateimmunity AT mariadominguez blueprintforcancerrelatedinflammationandhostinnateimmunity
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A Blueprint for Cancer-Related Inflammation and Host Innate Immunity

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