The use of superparamagnetic nanoparticles for prosthetic biofilm prevention

Erik N Taylor, Thomas J WebsterNanomedicine Laboratories, Division of Engineering, and Department of Orthopaedics, Brown University, Providence, RI 02912, USAAbstract: As with all surgical procedures, implantation comes with the added risk of infection. The goal of this in vitro study was to explore...

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Autores principales:	Erik N Taylor, Thomas J Webster
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2009
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/9b31f59480ef4124ac85f887d68d0635
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spelling	oai:doaj.org-article:9b31f59480ef4124ac85f887d68d06352021-12-02T02:38:18ZThe use of superparamagnetic nanoparticles for prosthetic biofilm prevention1176-91141178-2013https://doaj.org/article/9b31f59480ef4124ac85f887d68d06352009-08-01T00:00:00Zhttp://www.dovepress.com/the-use-of-superparamagnetic-nanoparticles-for-prosthetic-biofilm-prev-a3444https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Erik N Taylor, Thomas J WebsterNanomedicine Laboratories, Division of Engineering, and Department of Orthopaedics, Brown University, Providence, RI 02912, USAAbstract: As with all surgical procedures, implantation comes with the added risk of infection. The goal of this in vitro study was to explore the use of superparamagnetic iron oxide nanoparticles (SPION) as a multifunctional platform to prevent biofilm formation. Results showed for the first time decreased Staphylococcus epidermidis numbers when exposed to 100 &micro;g/ml of SPION for 12 hours and this trend continued for up to 48 hours. Prevention of colony assembly, a prerequisite to biofilm formation, was also observed at lower SPION dosages of 10 &micro;g/ml after 12 hours. Coupled with previous studies demonstrating enhanced bone cell functions in the presence of the same concentration of SPION, the present results provided much promise for the use of SPION for numerous anti-infection orthopedic applications.Keywords: superparamagnetic iron oxide nanoparticles (SPION), prosthetic infection, biofilm, nanotechnology, nanomedicine, Staphylococcus epidermidis Erik N TaylorThomas J WebsterDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2009, Iss default, Pp 145-152 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Erik N Taylor Thomas J Webster The use of superparamagnetic nanoparticles for prosthetic biofilm prevention
description	Erik N Taylor, Thomas J WebsterNanomedicine Laboratories, Division of Engineering, and Department of Orthopaedics, Brown University, Providence, RI 02912, USAAbstract: As with all surgical procedures, implantation comes with the added risk of infection. The goal of this in vitro study was to explore the use of superparamagnetic iron oxide nanoparticles (SPION) as a multifunctional platform to prevent biofilm formation. Results showed for the first time decreased Staphylococcus epidermidis numbers when exposed to 100 &micro;g/ml of SPION for 12 hours and this trend continued for up to 48 hours. Prevention of colony assembly, a prerequisite to biofilm formation, was also observed at lower SPION dosages of 10 &micro;g/ml after 12 hours. Coupled with previous studies demonstrating enhanced bone cell functions in the presence of the same concentration of SPION, the present results provided much promise for the use of SPION for numerous anti-infection orthopedic applications.Keywords: superparamagnetic iron oxide nanoparticles (SPION), prosthetic infection, biofilm, nanotechnology, nanomedicine, Staphylococcus epidermidis
format	article
author	Erik N Taylor Thomas J Webster
author_facet	Erik N Taylor Thomas J Webster
author_sort	Erik N Taylor
title	The use of superparamagnetic nanoparticles for prosthetic biofilm prevention
title_short	The use of superparamagnetic nanoparticles for prosthetic biofilm prevention
title_full	The use of superparamagnetic nanoparticles for prosthetic biofilm prevention
title_fullStr	The use of superparamagnetic nanoparticles for prosthetic biofilm prevention
title_full_unstemmed	The use of superparamagnetic nanoparticles for prosthetic biofilm prevention
title_sort	use of superparamagnetic nanoparticles for prosthetic biofilm prevention
publisher	Dove Medical Press
publishDate	2009
url	https://doaj.org/article/9b31f59480ef4124ac85f887d68d0635
work_keys_str_mv	AT erikntaylor theuseofsuperparamagneticnanoparticlesforprostheticbiofilmprevention AT thomasjwebster theuseofsuperparamagneticnanoparticlesforprostheticbiofilmprevention AT erikntaylor useofsuperparamagneticnanoparticlesforprostheticbiofilmprevention AT thomasjwebster useofsuperparamagneticnanoparticlesforprostheticbiofilmprevention
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The use of superparamagnetic nanoparticles for prosthetic biofilm prevention

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