Metabolomic alteration induced by psychotropic drugs: Short‐term metabolite profile as a predictor of weight gain evolution

Abstract Psychotropic drugs can induce strong metabolic adverse effects, potentially increasing morbidity and/or mortality of patients. Metabolomic profiling, by studying the levels of numerous metabolic intermediates and products in the blood, allows a more detailed examination of metabolism dysfun...

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Autores principales:	Marie Lenski, Jonathan Sidibé, Mehdi Gholam, Benjamin Hennart, Céline Dubath, Marc Augsburger, Armin vonGunten, Philippe Conus, Delphine Allorge, Aurelien Thomas, Chin B. Eap
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	Therapeutics. Pharmacology RM1-950 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/9b3236d03c894d60ac978e3c805fe31b
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spelling	oai:doaj.org-article:9b3236d03c894d60ac978e3c805fe31b2021-11-19T17:51:35ZMetabolomic alteration induced by psychotropic drugs: Short‐term metabolite profile as a predictor of weight gain evolution1752-80621752-805410.1111/cts.13122https://doaj.org/article/9b3236d03c894d60ac978e3c805fe31b2021-11-01T00:00:00Zhttps://doi.org/10.1111/cts.13122https://doaj.org/toc/1752-8054https://doaj.org/toc/1752-8062Abstract Psychotropic drugs can induce strong metabolic adverse effects, potentially increasing morbidity and/or mortality of patients. Metabolomic profiling, by studying the levels of numerous metabolic intermediates and products in the blood, allows a more detailed examination of metabolism dysfunctions. We aimed to identify blood metabolomic markers associated with weight gain in psychiatric patients. Sixty‐two patients starting a treatment known to induce weight gain were recruited. Two hundred and six selected metabolites implicated in various pathways were analyzed in plasma, at baseline and after 1 month of treatment. Additionally, 15 metabolites of the kynurenine pathway were quantified. This latter analysis was repeated in a confirmatory cohort of 24 patients. Among the 206 metabolites, a plasma metabolomic fingerprint after 1 month of treatment embedded 19 compounds from different chemical classes (amino acids, acylcarnitines, carboxylic acids, catecholamines, nucleosides, pyridine, and tetrapyrrole) potentially involved in metabolic disruption and inflammation processes. The predictive potential of such early metabolite changes on 3 months of weight evolution was then explored using a linear mixed‐effects model. Of these 19 metabolites, short‐term modifications of kynurenine, hexanoylcarnitine, and biliverdin, as well as kynurenine/tryptophan ratio at 1 month, were associated with 3 months weight evolution. Alterations of the kynurenine pathway were confirmed by quantification, in both exploratory and confirmatory cohorts. Our metabolomic study suggests a specific metabolic dysregulation after 1 month of treatment with psychotropic drugs known to induce weight gain. The identified metabolomic signature could contribute in the future to the prediction of weight gain in patients treated with psychotropic drugs.Marie LenskiJonathan SidibéMehdi GholamBenjamin HennartCéline DubathMarc AugsburgerArmin vonGuntenPhilippe ConusDelphine AllorgeAurelien ThomasChin B. EapWileyarticleTherapeutics. PharmacologyRM1-950Public aspects of medicineRA1-1270ENClinical and Translational Science, Vol 14, Iss 6, Pp 2544-2555 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Therapeutics. Pharmacology RM1-950 Public aspects of medicine RA1-1270
spellingShingle	Therapeutics. Pharmacology RM1-950 Public aspects of medicine RA1-1270 Marie Lenski Jonathan Sidibé Mehdi Gholam Benjamin Hennart Céline Dubath Marc Augsburger Armin vonGunten Philippe Conus Delphine Allorge Aurelien Thomas Chin B. Eap Metabolomic alteration induced by psychotropic drugs: Short‐term metabolite profile as a predictor of weight gain evolution
description	Abstract Psychotropic drugs can induce strong metabolic adverse effects, potentially increasing morbidity and/or mortality of patients. Metabolomic profiling, by studying the levels of numerous metabolic intermediates and products in the blood, allows a more detailed examination of metabolism dysfunctions. We aimed to identify blood metabolomic markers associated with weight gain in psychiatric patients. Sixty‐two patients starting a treatment known to induce weight gain were recruited. Two hundred and six selected metabolites implicated in various pathways were analyzed in plasma, at baseline and after 1 month of treatment. Additionally, 15 metabolites of the kynurenine pathway were quantified. This latter analysis was repeated in a confirmatory cohort of 24 patients. Among the 206 metabolites, a plasma metabolomic fingerprint after 1 month of treatment embedded 19 compounds from different chemical classes (amino acids, acylcarnitines, carboxylic acids, catecholamines, nucleosides, pyridine, and tetrapyrrole) potentially involved in metabolic disruption and inflammation processes. The predictive potential of such early metabolite changes on 3 months of weight evolution was then explored using a linear mixed‐effects model. Of these 19 metabolites, short‐term modifications of kynurenine, hexanoylcarnitine, and biliverdin, as well as kynurenine/tryptophan ratio at 1 month, were associated with 3 months weight evolution. Alterations of the kynurenine pathway were confirmed by quantification, in both exploratory and confirmatory cohorts. Our metabolomic study suggests a specific metabolic dysregulation after 1 month of treatment with psychotropic drugs known to induce weight gain. The identified metabolomic signature could contribute in the future to the prediction of weight gain in patients treated with psychotropic drugs.
format	article
author	Marie Lenski Jonathan Sidibé Mehdi Gholam Benjamin Hennart Céline Dubath Marc Augsburger Armin vonGunten Philippe Conus Delphine Allorge Aurelien Thomas Chin B. Eap
author_facet	Marie Lenski Jonathan Sidibé Mehdi Gholam Benjamin Hennart Céline Dubath Marc Augsburger Armin vonGunten Philippe Conus Delphine Allorge Aurelien Thomas Chin B. Eap
author_sort	Marie Lenski
title	Metabolomic alteration induced by psychotropic drugs: Short‐term metabolite profile as a predictor of weight gain evolution
title_short	Metabolomic alteration induced by psychotropic drugs: Short‐term metabolite profile as a predictor of weight gain evolution
title_full	Metabolomic alteration induced by psychotropic drugs: Short‐term metabolite profile as a predictor of weight gain evolution
title_fullStr	Metabolomic alteration induced by psychotropic drugs: Short‐term metabolite profile as a predictor of weight gain evolution
title_full_unstemmed	Metabolomic alteration induced by psychotropic drugs: Short‐term metabolite profile as a predictor of weight gain evolution
title_sort	metabolomic alteration induced by psychotropic drugs: short‐term metabolite profile as a predictor of weight gain evolution
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/9b3236d03c894d60ac978e3c805fe31b
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Metabolomic alteration induced by psychotropic drugs: Short‐term metabolite profile as a predictor of weight gain evolution

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