Break-induced replication promotes formation of lethal joint molecules dissolved by Srs2

Break-induced replication (BIR) is a double-strand break repair pathway that can lead to genomic instability. Here the authors show that the absence of Srs2 helicase during BIR leads to uncontrolled binding of Rad51 to single-stranded DNA, which promotes the formation of toxic intermediates that nee...

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Autores principales:	Rajula Elango, Ziwei Sheng, Jessica Jackson, Jenna DeCata, Younis Ibrahim, Nhung T. Pham, Diana H. Liang, Cynthia J. Sakofsky, Alessandro Vindigni, Kirill S. Lobachev, Grzegorz Ira, Anna Malkova
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9b329335ec744672ad3e5e67091d04d5
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spelling	oai:doaj.org-article:9b329335ec744672ad3e5e67091d04d52021-12-02T14:40:23ZBreak-induced replication promotes formation of lethal joint molecules dissolved by Srs210.1038/s41467-017-01987-22041-1723https://doaj.org/article/9b329335ec744672ad3e5e67091d04d52017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01987-2https://doaj.org/toc/2041-1723Break-induced replication (BIR) is a double-strand break repair pathway that can lead to genomic instability. Here the authors show that the absence of Srs2 helicase during BIR leads to uncontrolled binding of Rad51 to single-stranded DNA, which promotes the formation of toxic intermediates that need to be resolved by Mus81 or Yen1.Rajula ElangoZiwei ShengJessica JacksonJenna DeCataYounis IbrahimNhung T. PhamDiana H. LiangCynthia J. SakofskyAlessandro VindigniKirill S. LobachevGrzegorz IraAnna MalkovaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rajula Elango Ziwei Sheng Jessica Jackson Jenna DeCata Younis Ibrahim Nhung T. Pham Diana H. Liang Cynthia J. Sakofsky Alessandro Vindigni Kirill S. Lobachev Grzegorz Ira Anna Malkova Break-induced replication promotes formation of lethal joint molecules dissolved by Srs2
description	Break-induced replication (BIR) is a double-strand break repair pathway that can lead to genomic instability. Here the authors show that the absence of Srs2 helicase during BIR leads to uncontrolled binding of Rad51 to single-stranded DNA, which promotes the formation of toxic intermediates that need to be resolved by Mus81 or Yen1.
format	article
author	Rajula Elango Ziwei Sheng Jessica Jackson Jenna DeCata Younis Ibrahim Nhung T. Pham Diana H. Liang Cynthia J. Sakofsky Alessandro Vindigni Kirill S. Lobachev Grzegorz Ira Anna Malkova
author_facet	Rajula Elango Ziwei Sheng Jessica Jackson Jenna DeCata Younis Ibrahim Nhung T. Pham Diana H. Liang Cynthia J. Sakofsky Alessandro Vindigni Kirill S. Lobachev Grzegorz Ira Anna Malkova
author_sort	Rajula Elango
title	Break-induced replication promotes formation of lethal joint molecules dissolved by Srs2
title_short	Break-induced replication promotes formation of lethal joint molecules dissolved by Srs2
title_full	Break-induced replication promotes formation of lethal joint molecules dissolved by Srs2
title_fullStr	Break-induced replication promotes formation of lethal joint molecules dissolved by Srs2
title_full_unstemmed	Break-induced replication promotes formation of lethal joint molecules dissolved by Srs2
title_sort	break-induced replication promotes formation of lethal joint molecules dissolved by srs2
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/9b329335ec744672ad3e5e67091d04d5
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Break-induced replication promotes formation of lethal joint molecules dissolved by Srs2

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