Mitochondrial energetics with transmembrane electrostatically localized protons: do we have a thermotrophic feature?

Abstract Transmembrane electrostatically localized protons (TELP) theory has been recently recognized as an important addition over the classic Mitchell’s chemiosmosis; thus, the proton motive force (pmf) is largely contributed from TELP near the membrane. As an extension to this theory, a novel phe...

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Autor principal:	James Weifu Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9b340686db5e4ebcbec3c6fb320ddd52
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spelling	oai:doaj.org-article:9b340686db5e4ebcbec3c6fb320ddd522021-12-02T18:30:46ZMitochondrial energetics with transmembrane electrostatically localized protons: do we have a thermotrophic feature?10.1038/s41598-021-93853-x2045-2322https://doaj.org/article/9b340686db5e4ebcbec3c6fb320ddd522021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93853-xhttps://doaj.org/toc/2045-2322Abstract Transmembrane electrostatically localized protons (TELP) theory has been recently recognized as an important addition over the classic Mitchell’s chemiosmosis; thus, the proton motive force (pmf) is largely contributed from TELP near the membrane. As an extension to this theory, a novel phenomenon of mitochondrial thermotrophic function is now characterized by biophysical analyses of pmf in relation to the TELP concentrations at the liquid-membrane interface. This leads to the conclusion that the oxidative phosphorylation also utilizes environmental heat energy associated with the thermal kinetic energy (k B T) of TELP in mitochondria. The local pmf is now calculated to be in a range from 300 to 340 mV while the classic pmf (which underestimates the total pmf) is in a range from 60 to 210 mV in relation to a range of membrane potentials from 50 to 200 mV. Depending on TELP concentrations in mitochondria, this thermotrophic function raises pmf significantly by a factor of 2.6 to sixfold over the classic pmf. Therefore, mitochondria are capable of effectively utilizing the environmental heat energy with TELP for the synthesis of ATP, i.e., it can lock heat energy into the chemical form of energy for cellular functions.James Weifu LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q James Weifu Lee Mitochondrial energetics with transmembrane electrostatically localized protons: do we have a thermotrophic feature?
description	Abstract Transmembrane electrostatically localized protons (TELP) theory has been recently recognized as an important addition over the classic Mitchell’s chemiosmosis; thus, the proton motive force (pmf) is largely contributed from TELP near the membrane. As an extension to this theory, a novel phenomenon of mitochondrial thermotrophic function is now characterized by biophysical analyses of pmf in relation to the TELP concentrations at the liquid-membrane interface. This leads to the conclusion that the oxidative phosphorylation also utilizes environmental heat energy associated with the thermal kinetic energy (k B T) of TELP in mitochondria. The local pmf is now calculated to be in a range from 300 to 340 mV while the classic pmf (which underestimates the total pmf) is in a range from 60 to 210 mV in relation to a range of membrane potentials from 50 to 200 mV. Depending on TELP concentrations in mitochondria, this thermotrophic function raises pmf significantly by a factor of 2.6 to sixfold over the classic pmf. Therefore, mitochondria are capable of effectively utilizing the environmental heat energy with TELP for the synthesis of ATP, i.e., it can lock heat energy into the chemical form of energy for cellular functions.
format	article
author	James Weifu Lee
author_facet	James Weifu Lee
author_sort	James Weifu Lee
title	Mitochondrial energetics with transmembrane electrostatically localized protons: do we have a thermotrophic feature?
title_short	Mitochondrial energetics with transmembrane electrostatically localized protons: do we have a thermotrophic feature?
title_full	Mitochondrial energetics with transmembrane electrostatically localized protons: do we have a thermotrophic feature?
title_fullStr	Mitochondrial energetics with transmembrane electrostatically localized protons: do we have a thermotrophic feature?
title_full_unstemmed	Mitochondrial energetics with transmembrane electrostatically localized protons: do we have a thermotrophic feature?
title_sort	mitochondrial energetics with transmembrane electrostatically localized protons: do we have a thermotrophic feature?
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9b340686db5e4ebcbec3c6fb320ddd52
work_keys_str_mv	AT jamesweifulee mitochondrialenergeticswithtransmembraneelectrostaticallylocalizedprotonsdowehaveathermotrophicfeature
_version_	1718377995673010176

Mitochondrial energetics with transmembrane electrostatically localized protons: do we have a thermotrophic feature?

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