Positive effect of combined exercise on adipokines levels and pubertal signs in overweight and obese girls with central precocious puberty

Abstract Background The prevalence of precocious puberty is increasing. Obesity has been demonstrated to be associated with changes in the adipokine profile and incidence of early puberty in girls. This study assessed the pubertal signs, the levels of adiponectin, resistin, and tumor necrosis factor...

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Autores principales:	Elnaz Shokri, Ali Heidarianpour, Zahra Razavi
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Precocious puberty Combined exercise Detraining Adiponectin Resistin TNF-α Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/9b34927aaa1246ecb2253cb639408148
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spelling	oai:doaj.org-article:9b34927aaa1246ecb2253cb6394081482021-11-08T11:16:03ZPositive effect of combined exercise on adipokines levels and pubertal signs in overweight and obese girls with central precocious puberty10.1186/s12944-021-01588-51476-511Xhttps://doaj.org/article/9b34927aaa1246ecb2253cb6394081482021-11-01T00:00:00Zhttps://doi.org/10.1186/s12944-021-01588-5https://doaj.org/toc/1476-511XAbstract Background The prevalence of precocious puberty is increasing. Obesity has been demonstrated to be associated with changes in the adipokine profile and incidence of early puberty in girls. This study assessed the pubertal signs, the levels of adiponectin, resistin, and tumor necrosis factor-alpha (TNF-α) after 12 weeks of combined exercise and 4 weeks of detraining in overweight and obese girls with precocious puberty. Methods Thirty overweight and obese girls (aged 7–9) with precocious puberty, who had received Triptorelin, were randomly divided into two groups (15 exercise and 15 control). Initially, serum levels of adiponectin, resistin, TNF-α, luteinising hormone (LH), and follicle-stimulating hormone (FSH) and the signs of puberty progression (bone age, uterine length, and ovarian volume) were measured. The exercise group performed 60 min of combined (aerobic and resistance) exercise three times/week for 12 weeks. The control group did not receive any exercise. 48 h after the last training session and after 4 weeks of detraining, all research variables were measured (also in the control group). The statistical method used for data analysis was repeated measures ANOVA. Results In the exercise group, adiponectin significantly increased and resistin significantly decreased after 12 weeks. After 4 weeks of detraining, adiponectin significantly decreased, but resistin significantly increased. TNF-α levels did not change significantly during the study. There was no significant difference in all of the factors in the control group. Throughout the 16-week study period, the rate of puberty and LH significantly decreased in both exercise and control groups, but FSH, LH/FSH and ovarian volume significantly decreased in the exercise group alone (P<0.05). Conclusions Combined exercise increased adiponectin and decreased resistin and the rate of puberty. However, after 4 weeks of detraining, these effects diminished but did not disappear. Trial registration IRCT, IRCT56471. Registered 25 may 2021 - Retrospectively registered, https://fa.irct.ir/user/profileElnaz ShokriAli HeidarianpourZahra RazaviBMCarticlePrecocious pubertyCombined exerciseDetrainingAdiponectinResistinTNF-αNutritional diseases. Deficiency diseasesRC620-627ENLipids in Health and Disease, Vol 20, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Precocious puberty Combined exercise Detraining Adiponectin Resistin TNF-α Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	Precocious puberty Combined exercise Detraining Adiponectin Resistin TNF-α Nutritional diseases. Deficiency diseases RC620-627 Elnaz Shokri Ali Heidarianpour Zahra Razavi Positive effect of combined exercise on adipokines levels and pubertal signs in overweight and obese girls with central precocious puberty
description	Abstract Background The prevalence of precocious puberty is increasing. Obesity has been demonstrated to be associated with changes in the adipokine profile and incidence of early puberty in girls. This study assessed the pubertal signs, the levels of adiponectin, resistin, and tumor necrosis factor-alpha (TNF-α) after 12 weeks of combined exercise and 4 weeks of detraining in overweight and obese girls with precocious puberty. Methods Thirty overweight and obese girls (aged 7–9) with precocious puberty, who had received Triptorelin, were randomly divided into two groups (15 exercise and 15 control). Initially, serum levels of adiponectin, resistin, TNF-α, luteinising hormone (LH), and follicle-stimulating hormone (FSH) and the signs of puberty progression (bone age, uterine length, and ovarian volume) were measured. The exercise group performed 60 min of combined (aerobic and resistance) exercise three times/week for 12 weeks. The control group did not receive any exercise. 48 h after the last training session and after 4 weeks of detraining, all research variables were measured (also in the control group). The statistical method used for data analysis was repeated measures ANOVA. Results In the exercise group, adiponectin significantly increased and resistin significantly decreased after 12 weeks. After 4 weeks of detraining, adiponectin significantly decreased, but resistin significantly increased. TNF-α levels did not change significantly during the study. There was no significant difference in all of the factors in the control group. Throughout the 16-week study period, the rate of puberty and LH significantly decreased in both exercise and control groups, but FSH, LH/FSH and ovarian volume significantly decreased in the exercise group alone (P<0.05). Conclusions Combined exercise increased adiponectin and decreased resistin and the rate of puberty. However, after 4 weeks of detraining, these effects diminished but did not disappear. Trial registration IRCT, IRCT56471. Registered 25 may 2021 - Retrospectively registered, https://fa.irct.ir/user/profile
format	article
author	Elnaz Shokri Ali Heidarianpour Zahra Razavi
author_facet	Elnaz Shokri Ali Heidarianpour Zahra Razavi
author_sort	Elnaz Shokri
title	Positive effect of combined exercise on adipokines levels and pubertal signs in overweight and obese girls with central precocious puberty
title_short	Positive effect of combined exercise on adipokines levels and pubertal signs in overweight and obese girls with central precocious puberty
title_full	Positive effect of combined exercise on adipokines levels and pubertal signs in overweight and obese girls with central precocious puberty
title_fullStr	Positive effect of combined exercise on adipokines levels and pubertal signs in overweight and obese girls with central precocious puberty
title_full_unstemmed	Positive effect of combined exercise on adipokines levels and pubertal signs in overweight and obese girls with central precocious puberty
title_sort	positive effect of combined exercise on adipokines levels and pubertal signs in overweight and obese girls with central precocious puberty
publisher	BMC
publishDate	2021
url	https://doaj.org/article/9b34927aaa1246ecb2253cb639408148
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Positive effect of combined exercise on adipokines levels and pubertal signs in overweight and obese girls with central precocious puberty

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