Classification and Characteristics of Mesenchymal Stem Cells and Its Potential Therapeutic Mechanisms and Applications against Ischemic Stroke

Ischemic stroke is a serious cerebral disease that often induces death and long-term disability. As a currently available therapy for recanalization after ischemic stroke, thrombolysis, including intravenous thrombolysis and endovascular therapy, still cannot be applicable to all patients due to the...

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Autores principales:	Pian Gong, Wei Zhang, Yan He, Jianfeng Wang, Song Li, Songyu Chen, Qingsong Ye, Mingchang Li
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Internal medicine RC31-1245
Acceso en línea:	https://doaj.org/article/9b35ddfd9eef4821a914f8d59213cbc1
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spelling	oai:doaj.org-article:9b35ddfd9eef4821a914f8d59213cbc12021-11-22T01:10:39ZClassification and Characteristics of Mesenchymal Stem Cells and Its Potential Therapeutic Mechanisms and Applications against Ischemic Stroke1687-967810.1155/2021/2602871https://doaj.org/article/9b35ddfd9eef4821a914f8d59213cbc12021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/2602871https://doaj.org/toc/1687-9678Ischemic stroke is a serious cerebral disease that often induces death and long-term disability. As a currently available therapy for recanalization after ischemic stroke, thrombolysis, including intravenous thrombolysis and endovascular therapy, still cannot be applicable to all patients due to the narrow time window. Mesenchymal stem cell (MSC) transplantation therapy, which can trigger neuronal regeneration and repair, has been considered as a significant advance in treatment of ischemic stroke. MSC transplantation therapy has exhibited its potential to improve the neurological function in ischemic stroke. Our review describes the current progress and future perspective of MSC transplantation therapy in ischemic stroke treatment, including cell types, transplantation approaches, therapeutic mechanisms, and preliminary clinical trials of MSC transplantation, for providing us an update role of MSC transplantation in ischemic stroke treatment.Pian GongWei ZhangYan HeJianfeng WangSong LiSongyu ChenQingsong YeMingchang LiHindawi LimitedarticleInternal medicineRC31-1245ENStem Cells International, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Internal medicine RC31-1245
spellingShingle	Internal medicine RC31-1245 Pian Gong Wei Zhang Yan He Jianfeng Wang Song Li Songyu Chen Qingsong Ye Mingchang Li Classification and Characteristics of Mesenchymal Stem Cells and Its Potential Therapeutic Mechanisms and Applications against Ischemic Stroke
description	Ischemic stroke is a serious cerebral disease that often induces death and long-term disability. As a currently available therapy for recanalization after ischemic stroke, thrombolysis, including intravenous thrombolysis and endovascular therapy, still cannot be applicable to all patients due to the narrow time window. Mesenchymal stem cell (MSC) transplantation therapy, which can trigger neuronal regeneration and repair, has been considered as a significant advance in treatment of ischemic stroke. MSC transplantation therapy has exhibited its potential to improve the neurological function in ischemic stroke. Our review describes the current progress and future perspective of MSC transplantation therapy in ischemic stroke treatment, including cell types, transplantation approaches, therapeutic mechanisms, and preliminary clinical trials of MSC transplantation, for providing us an update role of MSC transplantation in ischemic stroke treatment.
format	article
author	Pian Gong Wei Zhang Yan He Jianfeng Wang Song Li Songyu Chen Qingsong Ye Mingchang Li
author_facet	Pian Gong Wei Zhang Yan He Jianfeng Wang Song Li Songyu Chen Qingsong Ye Mingchang Li
author_sort	Pian Gong
title	Classification and Characteristics of Mesenchymal Stem Cells and Its Potential Therapeutic Mechanisms and Applications against Ischemic Stroke
title_short	Classification and Characteristics of Mesenchymal Stem Cells and Its Potential Therapeutic Mechanisms and Applications against Ischemic Stroke
title_full	Classification and Characteristics of Mesenchymal Stem Cells and Its Potential Therapeutic Mechanisms and Applications against Ischemic Stroke
title_fullStr	Classification and Characteristics of Mesenchymal Stem Cells and Its Potential Therapeutic Mechanisms and Applications against Ischemic Stroke
title_full_unstemmed	Classification and Characteristics of Mesenchymal Stem Cells and Its Potential Therapeutic Mechanisms and Applications against Ischemic Stroke
title_sort	classification and characteristics of mesenchymal stem cells and its potential therapeutic mechanisms and applications against ischemic stroke
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/9b35ddfd9eef4821a914f8d59213cbc1
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Classification and Characteristics of Mesenchymal Stem Cells and Its Potential Therapeutic Mechanisms and Applications against Ischemic Stroke

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