Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis

How cells regulate their lysosomal proteolytic capacity is only partly understood. Here, the authors show that lysosomal protease deficiency or substrate overload induces lysosomal stress leading to activation of a STAT3-dependent, TFEB-independent pathway of lysosomal hydrolase expression.

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Autores principales:	Jonathan Martínez-Fábregas, Alan Prescott, Sander van Kasteren, Deena Leslie Pedrioli, Irwin McLean, Anna Moles, Thomas Reinheckel, Valeria Poli, Colin Watts
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9b365abacb3a4762883c30443e39abf9
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spelling	oai:doaj.org-article:9b365abacb3a4762883c30443e39abf92021-12-02T17:33:01ZLysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis10.1038/s41467-018-07741-62041-1723https://doaj.org/article/9b365abacb3a4762883c30443e39abf92018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07741-6https://doaj.org/toc/2041-1723How cells regulate their lysosomal proteolytic capacity is only partly understood. Here, the authors show that lysosomal protease deficiency or substrate overload induces lysosomal stress leading to activation of a STAT3-dependent, TFEB-independent pathway of lysosomal hydrolase expression.Jonathan Martínez-FábregasAlan PrescottSander van KasterenDeena Leslie PedrioliIrwin McLeanAnna MolesThomas ReinheckelValeria PoliColin WattsNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jonathan Martínez-Fábregas Alan Prescott Sander van Kasteren Deena Leslie Pedrioli Irwin McLean Anna Moles Thomas Reinheckel Valeria Poli Colin Watts Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis
description	How cells regulate their lysosomal proteolytic capacity is only partly understood. Here, the authors show that lysosomal protease deficiency or substrate overload induces lysosomal stress leading to activation of a STAT3-dependent, TFEB-independent pathway of lysosomal hydrolase expression.
format	article
author	Jonathan Martínez-Fábregas Alan Prescott Sander van Kasteren Deena Leslie Pedrioli Irwin McLean Anna Moles Thomas Reinheckel Valeria Poli Colin Watts
author_facet	Jonathan Martínez-Fábregas Alan Prescott Sander van Kasteren Deena Leslie Pedrioli Irwin McLean Anna Moles Thomas Reinheckel Valeria Poli Colin Watts
author_sort	Jonathan Martínez-Fábregas
title	Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis
title_short	Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis
title_full	Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis
title_fullStr	Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis
title_full_unstemmed	Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis
title_sort	lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated stat3-dependent pathway of lysosomal homeostasis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/9b365abacb3a4762883c30443e39abf9
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Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis

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