Promising Effects of Vitex Agnus-Castus on Quality of Life and Sexual Function in Premenopausal Relapsing Remitting Multiple Sclerosis Patients

Background and aims:Current therapeutic regimens are not able to solve hormonal imbalance in young multiple sclerosis (MS) women and the clinical benefits of hormone therapy in MS patients remain controversial. This open labeled pilot study was aimed to find the role of Vitex agnus-castus plant supp...

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Autores principales:	Sara Rahgooy, Sepideh Arbabi Bidgoli, Saeed Shahbeigi, Shima Tavakol, Mohammad Hossein Salehi Surmaghi
Formato:	article
Lenguaje:	EN
Publicado:	Shahrekord University of Medical Sciences 2020
Materias:	multiple sclerosis vitex agnus-castus quality of life testosterone molecular docking Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9b3808c6146a4ff29d0d5de0532a74d0
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spelling	oai:doaj.org-article:9b3808c6146a4ff29d0d5de0532a74d02021-11-13T05:12:32ZPromising Effects of Vitex Agnus-Castus on Quality of Life and Sexual Function in Premenopausal Relapsing Remitting Multiple Sclerosis Patients2423-3579https://doaj.org/article/9b3808c6146a4ff29d0d5de0532a74d02020-07-01T00:00:00Zhttp://herbmed.skums.ac.ir/article_244828_ef60c76832bbd237f62a97834a113f94.pdfhttps://doaj.org/toc/2423-3579Background and aims:Current therapeutic regimens are not able to solve hormonal imbalance in young multiple sclerosis (MS) women and the clinical benefits of hormone therapy in MS patients remain controversial. This open labeled pilot study was aimed to find the role of Vitex agnus-castus plant supplement daily regimen in serum testosterone level , Expanded Disability Status Scale (EDSS), sexual function and overall quality of life in premenopausal MS patients. Methods: To achieve these goals, Molecular Docking on Vitex agnus-castus standard fruit extract constitutes performed and 30 eligible patients were selected for the clinical part of this study. Patients received two Vitagnus® film tablets in addition to their drugs for 90 days. Results: Some plant extract components showed strong affinity to Androgen Receptor Ligand binding domain. Significant reduction in EDSS (1.839 vs.1.643, p=0.003) and significant elevation in serum testosterone levels [388.6(±0.16900) vs. 468. (±0.18144) 2ng/dL (p=0.026)] were also observed at the completion of the intervention. Menstrual irregularities disappeared in all 28 patients who completed this study. MSQL-54 criteria at the completion of study (day 91) showed lower stress levels, improved vitality/emotional health and normalized sexual activities without significant effect on sleep disorders and cognitive functions of patients. Vitex agnus-castus treatment by predictable AR LBD affinity improved the emotional state, sexual life, EDSS score and overall quality of life in premenopausal RRMS patients. Conclusion: Our results suggest Vitagnus® film tablet as safe and promising supplement with some benefits in MS women who are suffering from disease induced emotional and sexual impairments.Sara RahgooySepideh Arbabi BidgoliSaeed ShahbeigiShima TavakolMohammad Hossein Salehi SurmaghiShahrekord University of Medical Sciencesarticlemultiple sclerosisvitex agnus-castusquality of lifetestosteronemolecular dockingMedicineRScienceQENAdvanced Herbal Medicine , Vol 6, Iss 2, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	multiple sclerosis vitex agnus-castus quality of life testosterone molecular docking Medicine R Science Q
spellingShingle	multiple sclerosis vitex agnus-castus quality of life testosterone molecular docking Medicine R Science Q Sara Rahgooy Sepideh Arbabi Bidgoli Saeed Shahbeigi Shima Tavakol Mohammad Hossein Salehi Surmaghi Promising Effects of Vitex Agnus-Castus on Quality of Life and Sexual Function in Premenopausal Relapsing Remitting Multiple Sclerosis Patients
description	Background and aims:Current therapeutic regimens are not able to solve hormonal imbalance in young multiple sclerosis (MS) women and the clinical benefits of hormone therapy in MS patients remain controversial. This open labeled pilot study was aimed to find the role of Vitex agnus-castus plant supplement daily regimen in serum testosterone level , Expanded Disability Status Scale (EDSS), sexual function and overall quality of life in premenopausal MS patients. Methods: To achieve these goals, Molecular Docking on Vitex agnus-castus standard fruit extract constitutes performed and 30 eligible patients were selected for the clinical part of this study. Patients received two Vitagnus® film tablets in addition to their drugs for 90 days. Results: Some plant extract components showed strong affinity to Androgen Receptor Ligand binding domain. Significant reduction in EDSS (1.839 vs.1.643, p=0.003) and significant elevation in serum testosterone levels [388.6(±0.16900) vs. 468. (±0.18144) 2ng/dL (p=0.026)] were also observed at the completion of the intervention. Menstrual irregularities disappeared in all 28 patients who completed this study. MSQL-54 criteria at the completion of study (day 91) showed lower stress levels, improved vitality/emotional health and normalized sexual activities without significant effect on sleep disorders and cognitive functions of patients. Vitex agnus-castus treatment by predictable AR LBD affinity improved the emotional state, sexual life, EDSS score and overall quality of life in premenopausal RRMS patients. Conclusion: Our results suggest Vitagnus® film tablet as safe and promising supplement with some benefits in MS women who are suffering from disease induced emotional and sexual impairments.
format	article
author	Sara Rahgooy Sepideh Arbabi Bidgoli Saeed Shahbeigi Shima Tavakol Mohammad Hossein Salehi Surmaghi
author_facet	Sara Rahgooy Sepideh Arbabi Bidgoli Saeed Shahbeigi Shima Tavakol Mohammad Hossein Salehi Surmaghi
author_sort	Sara Rahgooy
title	Promising Effects of Vitex Agnus-Castus on Quality of Life and Sexual Function in Premenopausal Relapsing Remitting Multiple Sclerosis Patients
title_short	Promising Effects of Vitex Agnus-Castus on Quality of Life and Sexual Function in Premenopausal Relapsing Remitting Multiple Sclerosis Patients
title_full	Promising Effects of Vitex Agnus-Castus on Quality of Life and Sexual Function in Premenopausal Relapsing Remitting Multiple Sclerosis Patients
title_fullStr	Promising Effects of Vitex Agnus-Castus on Quality of Life and Sexual Function in Premenopausal Relapsing Remitting Multiple Sclerosis Patients
title_full_unstemmed	Promising Effects of Vitex Agnus-Castus on Quality of Life and Sexual Function in Premenopausal Relapsing Remitting Multiple Sclerosis Patients
title_sort	promising effects of vitex agnus-castus on quality of life and sexual function in premenopausal relapsing remitting multiple sclerosis patients
publisher	Shahrekord University of Medical Sciences
publishDate	2020
url	https://doaj.org/article/9b3808c6146a4ff29d0d5de0532a74d0
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Promising Effects of Vitex Agnus-Castus on Quality of Life and Sexual Function in Premenopausal Relapsing Remitting Multiple Sclerosis Patients

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