Peripheral blood neurotrophic factor levels in children with autism spectrum disorder: a meta-analysis

Abstract Increasing evidence suggests that abnormal regulation of neurotrophic factors is involved in the etiology and pathogenesis of Autism Spectrum Disorder (ASD). However, clinical data on neurotrophic factor levels in children with ASD were inconsistent. Therefore, we performed a systematic rev...

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Autores principales:	Shu-Han Liu, Xiao-Jie Shi, Fang-Cheng Fan, Yong Cheng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9b3a7d5a87d0466399c75efe2a144eba
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spelling	oai:doaj.org-article:9b3a7d5a87d0466399c75efe2a144eba2021-12-02T15:13:01ZPeripheral blood neurotrophic factor levels in children with autism spectrum disorder: a meta-analysis10.1038/s41598-020-79080-w2045-2322https://doaj.org/article/9b3a7d5a87d0466399c75efe2a144eba2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79080-whttps://doaj.org/toc/2045-2322Abstract Increasing evidence suggests that abnormal regulation of neurotrophic factors is involved in the etiology and pathogenesis of Autism Spectrum Disorder (ASD). However, clinical data on neurotrophic factor levels in children with ASD were inconsistent. Therefore, we performed a systematic review of peripheral blood neurotrophic factors levels in children with ASD, and quantitatively summarized the clinical data of peripheral blood neurotrophic factors in ASD children and healthy controls. A systematic search of PubMed and Web of Science identified 31 studies with 2627 ASD children and 4418 healthy controls to be included in the meta-analysis. The results of random effect meta-analysis showed that the peripheral blood levels of brain-derived neurotrophic factor (Hedges’ g = 0.302; 95% CI = 0.014 to 0.591; P = 0.040) , nerve growth factor (Hedges’ g = 0.395; 95% CI = 0.104 to 0.686; P = 0.008) and vascular endothelial growth factor (VEGF) (Hedges’ g = 0.097; 95% CI = 0.018 to 0.175; P = 0.016) in children with ASD were significantly higher than that of healthy controls, whereas blood neurotrophin-3 (Hedges’ g = − 0.795; 95% CI = − 1.723 to 0.134; P = 0.093) and neurotrophin-4 (Hedges’ g = 0.182; 95% CI = − 0.285 to 0.650; P = 0.445) levels did not show significant differences between cases and controls. Taken together, these results clarified circulating neurotrophic factor profile in children with ASD, strengthening clinical evidence of neurotrophic factor aberrations in children with ASD.Shu-Han LiuXiao-Jie ShiFang-Cheng FanYong ChengNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shu-Han Liu Xiao-Jie Shi Fang-Cheng Fan Yong Cheng Peripheral blood neurotrophic factor levels in children with autism spectrum disorder: a meta-analysis
description	Abstract Increasing evidence suggests that abnormal regulation of neurotrophic factors is involved in the etiology and pathogenesis of Autism Spectrum Disorder (ASD). However, clinical data on neurotrophic factor levels in children with ASD were inconsistent. Therefore, we performed a systematic review of peripheral blood neurotrophic factors levels in children with ASD, and quantitatively summarized the clinical data of peripheral blood neurotrophic factors in ASD children and healthy controls. A systematic search of PubMed and Web of Science identified 31 studies with 2627 ASD children and 4418 healthy controls to be included in the meta-analysis. The results of random effect meta-analysis showed that the peripheral blood levels of brain-derived neurotrophic factor (Hedges’ g = 0.302; 95% CI = 0.014 to 0.591; P = 0.040) , nerve growth factor (Hedges’ g = 0.395; 95% CI = 0.104 to 0.686; P = 0.008) and vascular endothelial growth factor (VEGF) (Hedges’ g = 0.097; 95% CI = 0.018 to 0.175; P = 0.016) in children with ASD were significantly higher than that of healthy controls, whereas blood neurotrophin-3 (Hedges’ g = − 0.795; 95% CI = − 1.723 to 0.134; P = 0.093) and neurotrophin-4 (Hedges’ g = 0.182; 95% CI = − 0.285 to 0.650; P = 0.445) levels did not show significant differences between cases and controls. Taken together, these results clarified circulating neurotrophic factor profile in children with ASD, strengthening clinical evidence of neurotrophic factor aberrations in children with ASD.
format	article
author	Shu-Han Liu Xiao-Jie Shi Fang-Cheng Fan Yong Cheng
author_facet	Shu-Han Liu Xiao-Jie Shi Fang-Cheng Fan Yong Cheng
author_sort	Shu-Han Liu
title	Peripheral blood neurotrophic factor levels in children with autism spectrum disorder: a meta-analysis
title_short	Peripheral blood neurotrophic factor levels in children with autism spectrum disorder: a meta-analysis
title_full	Peripheral blood neurotrophic factor levels in children with autism spectrum disorder: a meta-analysis
title_fullStr	Peripheral blood neurotrophic factor levels in children with autism spectrum disorder: a meta-analysis
title_full_unstemmed	Peripheral blood neurotrophic factor levels in children with autism spectrum disorder: a meta-analysis
title_sort	peripheral blood neurotrophic factor levels in children with autism spectrum disorder: a meta-analysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9b3a7d5a87d0466399c75efe2a144eba
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Peripheral blood neurotrophic factor levels in children with autism spectrum disorder: a meta-analysis

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