Sepsis and the Human Microbiome. Just Another Kind of Organ Failure? A Review

Next-generation sequencing (NGS) has been further optimised during the last years and has given us new insights into the human microbiome. The 16S rDNA sequencing, especially, is a cheap, fast, and reliable method that can reveal significantly more microorganisms compared to culture-based diagnostic...

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Autores principales:	Kevin M. Tourelle, Sebastien Boutin, Markus A. Weigand, Felix C. F. Schmitt
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	microbiome microbiota sepsis ARDS postoperative complications next-generation sequencing Medicine R
Acceso en línea:	https://doaj.org/article/9b3b4f793a284ddab96f048cb3eaf7e1
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spelling	oai:doaj.org-article:9b3b4f793a284ddab96f048cb3eaf7e12021-11-11T17:29:59ZSepsis and the Human Microbiome. Just Another Kind of Organ Failure? A Review10.3390/jcm102148312077-0383https://doaj.org/article/9b3b4f793a284ddab96f048cb3eaf7e12021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/4831https://doaj.org/toc/2077-0383Next-generation sequencing (NGS) has been further optimised during the last years and has given us new insights into the human microbiome. The 16S rDNA sequencing, especially, is a cheap, fast, and reliable method that can reveal significantly more microorganisms compared to culture-based diagnostics. It might be a useful method for patients suffering from severe sepsis and at risk of organ failure because early detection and differentiation between healthy and harmful microorganisms are essential for effective therapy. In particular, the gut and lung microbiome in critically ill patients have been probed by NGS. For this review, an iterative approach was used. Current data suggest that an altered microbiome with a decreased alpha-diversity compared to healthy individuals could negatively influence the individual patient’s outcome. In the future, NGS may not only contribute to the diagnosis of complications. Patients at risk could also be identified before surgery or even during their stay in an intensive care unit. Unfortunately, there is still a lack of knowledge to make precise statements about what constitutes a healthy microbiome, which patients exactly have an increased perioperative risk, and what could be a possible therapy to strengthen the microbiome. This work is an iterative review that presents the current state of knowledge in this field.Kevin M. TourelleSebastien BoutinMarkus A. WeigandFelix C. F. SchmittMDPI AGarticlemicrobiomemicrobiotasepsisARDSpostoperative complicationsnext-generation sequencingMedicineRENJournal of Clinical Medicine, Vol 10, Iss 4831, p 4831 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	microbiome microbiota sepsis ARDS postoperative complications next-generation sequencing Medicine R
spellingShingle	microbiome microbiota sepsis ARDS postoperative complications next-generation sequencing Medicine R Kevin M. Tourelle Sebastien Boutin Markus A. Weigand Felix C. F. Schmitt Sepsis and the Human Microbiome. Just Another Kind of Organ Failure? A Review
description	Next-generation sequencing (NGS) has been further optimised during the last years and has given us new insights into the human microbiome. The 16S rDNA sequencing, especially, is a cheap, fast, and reliable method that can reveal significantly more microorganisms compared to culture-based diagnostics. It might be a useful method for patients suffering from severe sepsis and at risk of organ failure because early detection and differentiation between healthy and harmful microorganisms are essential for effective therapy. In particular, the gut and lung microbiome in critically ill patients have been probed by NGS. For this review, an iterative approach was used. Current data suggest that an altered microbiome with a decreased alpha-diversity compared to healthy individuals could negatively influence the individual patient’s outcome. In the future, NGS may not only contribute to the diagnosis of complications. Patients at risk could also be identified before surgery or even during their stay in an intensive care unit. Unfortunately, there is still a lack of knowledge to make precise statements about what constitutes a healthy microbiome, which patients exactly have an increased perioperative risk, and what could be a possible therapy to strengthen the microbiome. This work is an iterative review that presents the current state of knowledge in this field.
format	article
author	Kevin M. Tourelle Sebastien Boutin Markus A. Weigand Felix C. F. Schmitt
author_facet	Kevin M. Tourelle Sebastien Boutin Markus A. Weigand Felix C. F. Schmitt
author_sort	Kevin M. Tourelle
title	Sepsis and the Human Microbiome. Just Another Kind of Organ Failure? A Review
title_short	Sepsis and the Human Microbiome. Just Another Kind of Organ Failure? A Review
title_full	Sepsis and the Human Microbiome. Just Another Kind of Organ Failure? A Review
title_fullStr	Sepsis and the Human Microbiome. Just Another Kind of Organ Failure? A Review
title_full_unstemmed	Sepsis and the Human Microbiome. Just Another Kind of Organ Failure? A Review
title_sort	sepsis and the human microbiome. just another kind of organ failure? a review
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/9b3b4f793a284ddab96f048cb3eaf7e1
work_keys_str_mv	AT kevinmtourelle sepsisandthehumanmicrobiomejustanotherkindoforganfailureareview AT sebastienboutin sepsisandthehumanmicrobiomejustanotherkindoforganfailureareview AT markusaweigand sepsisandthehumanmicrobiomejustanotherkindoforganfailureareview AT felixcfschmitt sepsisandthehumanmicrobiomejustanotherkindoforganfailureareview
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Sepsis and the Human Microbiome. Just Another Kind of Organ Failure? A Review

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