Association between haemorrhagic fever with renal syndrome and cancers

ABSTRACT: Objectives: To investigate the risk of haematologic and solid organ malignancies in patients with haemorrhagic fever with renal syndrome (HFRS) compared with the general population. Methods: This propensity-score-matched cohort study was conducted using data collected from the Korean nati...

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Autores principales:	Yong Jin Yi, Minsun Kang, Won-Keun Kim, Kyungmin Huh, Jonas Klingström, Jin-Won Song, Jaehun Jung
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Hantavirus Haemorrhagic fever with renal syndrome Cancer Survival analysis Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/9b41f6c7a0db4c42a2743260fc58f096
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spelling	oai:doaj.org-article:9b41f6c7a0db4c42a2743260fc58f0962021-11-04T04:26:55ZAssociation between haemorrhagic fever with renal syndrome and cancers1201-971210.1016/j.ijid.2021.10.014https://doaj.org/article/9b41f6c7a0db4c42a2743260fc58f0962021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1201971221008055https://doaj.org/toc/1201-9712ABSTRACT: Objectives: To investigate the risk of haematologic and solid organ malignancies in patients with haemorrhagic fever with renal syndrome (HFRS) compared with the general population. Methods: This propensity-score-matched cohort study was conducted using data collected from the Korean national health insurance service (NHIS) between January 2003 and December 2017. The HFRS cohort included 5888 newly diagnosed cases of HFRS, and 412,804 general participants from the NHIS database were included as the control cohort. The incidence rate of malignancies was assessed and compared between the HFRS and control cohorts. Results: There were 64 cases of haematologic malignancy in 236,286 person-years of observation, and 1245 cases of solid organ cancer in 209,333 person-years. The risks of haematologic malignancy and solid organ cancer were significantly higher in the HFRS cohort [adjusted hazards ratio (aHR) 4.10, 95% confidence interval (CI) 2.36–7.14] than the control cohort [aHR 2.97, 95% CI 2.60–3.38). In subgroup analysis, the HFRS cohort was associated with high hazard ratios for leukaemia and non-Hodgkin lymphoma. The HFRS cohort also had increased aHRs for all types of solid organ cancer. Conclusions: Patients with HFRS are at increased risk of both haematologic and solid organ malignancies compared with the general population, and this increased proportionally over time. Careful monitoring for malignancy after the onset of HFRS may be necessary.Yong Jin YiMinsun KangWon-Keun KimKyungmin HuhJonas KlingströmJin-Won SongJaehun JungElsevierarticleHantavirusHaemorrhagic fever with renal syndromeCancerSurvival analysisInfectious and parasitic diseasesRC109-216ENInternational Journal of Infectious Diseases, Vol 113, Iss , Pp 127-135 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Hantavirus Haemorrhagic fever with renal syndrome Cancer Survival analysis Infectious and parasitic diseases RC109-216
spellingShingle	Hantavirus Haemorrhagic fever with renal syndrome Cancer Survival analysis Infectious and parasitic diseases RC109-216 Yong Jin Yi Minsun Kang Won-Keun Kim Kyungmin Huh Jonas Klingström Jin-Won Song Jaehun Jung Association between haemorrhagic fever with renal syndrome and cancers
description	ABSTRACT: Objectives: To investigate the risk of haematologic and solid organ malignancies in patients with haemorrhagic fever with renal syndrome (HFRS) compared with the general population. Methods: This propensity-score-matched cohort study was conducted using data collected from the Korean national health insurance service (NHIS) between January 2003 and December 2017. The HFRS cohort included 5888 newly diagnosed cases of HFRS, and 412,804 general participants from the NHIS database were included as the control cohort. The incidence rate of malignancies was assessed and compared between the HFRS and control cohorts. Results: There were 64 cases of haematologic malignancy in 236,286 person-years of observation, and 1245 cases of solid organ cancer in 209,333 person-years. The risks of haematologic malignancy and solid organ cancer were significantly higher in the HFRS cohort [adjusted hazards ratio (aHR) 4.10, 95% confidence interval (CI) 2.36–7.14] than the control cohort [aHR 2.97, 95% CI 2.60–3.38). In subgroup analysis, the HFRS cohort was associated with high hazard ratios for leukaemia and non-Hodgkin lymphoma. The HFRS cohort also had increased aHRs for all types of solid organ cancer. Conclusions: Patients with HFRS are at increased risk of both haematologic and solid organ malignancies compared with the general population, and this increased proportionally over time. Careful monitoring for malignancy after the onset of HFRS may be necessary.
format	article
author	Yong Jin Yi Minsun Kang Won-Keun Kim Kyungmin Huh Jonas Klingström Jin-Won Song Jaehun Jung
author_facet	Yong Jin Yi Minsun Kang Won-Keun Kim Kyungmin Huh Jonas Klingström Jin-Won Song Jaehun Jung
author_sort	Yong Jin Yi
title	Association between haemorrhagic fever with renal syndrome and cancers
title_short	Association between haemorrhagic fever with renal syndrome and cancers
title_full	Association between haemorrhagic fever with renal syndrome and cancers
title_fullStr	Association between haemorrhagic fever with renal syndrome and cancers
title_full_unstemmed	Association between haemorrhagic fever with renal syndrome and cancers
title_sort	association between haemorrhagic fever with renal syndrome and cancers
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/9b41f6c7a0db4c42a2743260fc58f096
work_keys_str_mv	AT yongjinyi associationbetweenhaemorrhagicfeverwithrenalsyndromeandcancers AT minsunkang associationbetweenhaemorrhagicfeverwithrenalsyndromeandcancers AT wonkeunkim associationbetweenhaemorrhagicfeverwithrenalsyndromeandcancers AT kyungminhuh associationbetweenhaemorrhagicfeverwithrenalsyndromeandcancers AT jonasklingstrom associationbetweenhaemorrhagicfeverwithrenalsyndromeandcancers AT jinwonsong associationbetweenhaemorrhagicfeverwithrenalsyndromeandcancers AT jaehunjung associationbetweenhaemorrhagicfeverwithrenalsyndromeandcancers
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Association between haemorrhagic fever with renal syndrome and cancers

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