Tankyrase disrupts metabolic homeostasis and promotes tumorigenesis by inhibiting LKB1-AMPK signalling

The LKB1/AMPK is crucial for maintaining cellular homeostasis and is often deregulated in tumours. Here, the authors show that the ribosylation of LKB1 by tankyrase-RNF146 axis results in attenuation of LKB1 pathway activation.

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Autores principales:	Nan Li, Yifan Wang, Shinya Neri, Yuanli Zhen, Lon Wolf R. Fong, Yawei Qiao, Xu Li, Zhen Chen, Clifford Stephan, Weiye Deng, Rui Ye, Wen Jiang, Shuxing Zhang, Yonghao Yu, Mien-Chie Hung, Junjie Chen, Steven H. Lin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9b4222506e07478e9b0dbb2ab2af74f5
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spelling	oai:doaj.org-article:9b4222506e07478e9b0dbb2ab2af74f52021-12-02T16:50:56ZTankyrase disrupts metabolic homeostasis and promotes tumorigenesis by inhibiting LKB1-AMPK signalling10.1038/s41467-019-12377-12041-1723https://doaj.org/article/9b4222506e07478e9b0dbb2ab2af74f52019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12377-1https://doaj.org/toc/2041-1723The LKB1/AMPK is crucial for maintaining cellular homeostasis and is often deregulated in tumours. Here, the authors show that the ribosylation of LKB1 by tankyrase-RNF146 axis results in attenuation of LKB1 pathway activation.Nan LiYifan WangShinya NeriYuanli ZhenLon Wolf R. FongYawei QiaoXu LiZhen ChenClifford StephanWeiye DengRui YeWen JiangShuxing ZhangYonghao YuMien-Chie HungJunjie ChenSteven H. LinNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nan Li Yifan Wang Shinya Neri Yuanli Zhen Lon Wolf R. Fong Yawei Qiao Xu Li Zhen Chen Clifford Stephan Weiye Deng Rui Ye Wen Jiang Shuxing Zhang Yonghao Yu Mien-Chie Hung Junjie Chen Steven H. Lin Tankyrase disrupts metabolic homeostasis and promotes tumorigenesis by inhibiting LKB1-AMPK signalling
description	The LKB1/AMPK is crucial for maintaining cellular homeostasis and is often deregulated in tumours. Here, the authors show that the ribosylation of LKB1 by tankyrase-RNF146 axis results in attenuation of LKB1 pathway activation.
format	article
author	Nan Li Yifan Wang Shinya Neri Yuanli Zhen Lon Wolf R. Fong Yawei Qiao Xu Li Zhen Chen Clifford Stephan Weiye Deng Rui Ye Wen Jiang Shuxing Zhang Yonghao Yu Mien-Chie Hung Junjie Chen Steven H. Lin
author_facet	Nan Li Yifan Wang Shinya Neri Yuanli Zhen Lon Wolf R. Fong Yawei Qiao Xu Li Zhen Chen Clifford Stephan Weiye Deng Rui Ye Wen Jiang Shuxing Zhang Yonghao Yu Mien-Chie Hung Junjie Chen Steven H. Lin
author_sort	Nan Li
title	Tankyrase disrupts metabolic homeostasis and promotes tumorigenesis by inhibiting LKB1-AMPK signalling
title_short	Tankyrase disrupts metabolic homeostasis and promotes tumorigenesis by inhibiting LKB1-AMPK signalling
title_full	Tankyrase disrupts metabolic homeostasis and promotes tumorigenesis by inhibiting LKB1-AMPK signalling
title_fullStr	Tankyrase disrupts metabolic homeostasis and promotes tumorigenesis by inhibiting LKB1-AMPK signalling
title_full_unstemmed	Tankyrase disrupts metabolic homeostasis and promotes tumorigenesis by inhibiting LKB1-AMPK signalling
title_sort	tankyrase disrupts metabolic homeostasis and promotes tumorigenesis by inhibiting lkb1-ampk signalling
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/9b4222506e07478e9b0dbb2ab2af74f5
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Tankyrase disrupts metabolic homeostasis and promotes tumorigenesis by inhibiting LKB1-AMPK signalling

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