Diacerein ameliorates kidney injury induced by cisplatin in rats by activation of Nrf2/Ho-1 pathway and Bax down-regulation

Cisplatin is an antineoplastic medicine used for solid tumor treatment. The main side effect that limits its dose is nephrotoxicity. Diacerein has been used for the treatment of joint diseases like osteoarthritis. It also has exhibited analgesic effects and antipyretic activities in animal models so...

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Autores principales:	Nashwa Barakat, Lamiaa A.A. Barakat, Mahmoud M. Zakaria, Salma M. Khirallah
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Cisplatin Diacerein Nephrotoxicity Nrf2/Ho-1 pathway Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/9b46c577a45547b68c168a53a77df5ae
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spelling	oai:doaj.org-article:9b46c577a45547b68c168a53a77df5ae2021-11-20T04:56:55ZDiacerein ameliorates kidney injury induced by cisplatin in rats by activation of Nrf2/Ho-1 pathway and Bax down-regulation1319-562X10.1016/j.sjbs.2021.08.025https://doaj.org/article/9b46c577a45547b68c168a53a77df5ae2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1319562X21007105https://doaj.org/toc/1319-562XCisplatin is an antineoplastic medicine used for solid tumor treatment. The main side effect that limits its dose is nephrotoxicity. Diacerein has been used for the treatment of joint diseases like osteoarthritis. It also has exhibited analgesic effects and antipyretic activities in animal models so this study targets to indicate the diacerein effect on nephrotoxicity induced by cisplatin in rats. Rats were distributed into four groups: normal healthy control; diacerein, which received diacerein daily by gastric gavage (50 mg/kg/day); cisplatin, which received only one intraperitoneal injection of cisplatin (6 mg/kg) and cisplatin and diacerein, which received diacerein daily after the cisplatin injection till 7th and 12th days, respectively. Diacerein treatment decreased kidney function markers so the cisplatin effect was reversed. Also, diacerein increased the renal antioxidants and decreased oxidative stress. Diacerein up-regulated Ho-1 (heme oxygenase 1), Nrf2 (Nuclear factor erythroid 2–related factor 2) and endothelial nitric oxide synthase (eNOS) genes expression, while down-regulated Bcl-2-associated X protein (Bax) gene expression. Furthermore, the renal transforming growth factor beta-1 (TGF-β1) decreased by the diacerein effect. Consequently, diacerein has a curative effect against cisplatin due to its anti-inflammatory, antioxidant, and antiapoptotic properties.Nashwa BarakatLamiaa A.A. BarakatMahmoud M. ZakariaSalma M. KhirallahElsevierarticleCisplatinDiacereinNephrotoxicityNrf2/Ho-1 pathwayBiology (General)QH301-705.5ENSaudi Journal of Biological Sciences, Vol 28, Iss 12, Pp 7219-7226 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cisplatin Diacerein Nephrotoxicity Nrf2/Ho-1 pathway Biology (General) QH301-705.5
spellingShingle	Cisplatin Diacerein Nephrotoxicity Nrf2/Ho-1 pathway Biology (General) QH301-705.5 Nashwa Barakat Lamiaa A.A. Barakat Mahmoud M. Zakaria Salma M. Khirallah Diacerein ameliorates kidney injury induced by cisplatin in rats by activation of Nrf2/Ho-1 pathway and Bax down-regulation
description	Cisplatin is an antineoplastic medicine used for solid tumor treatment. The main side effect that limits its dose is nephrotoxicity. Diacerein has been used for the treatment of joint diseases like osteoarthritis. It also has exhibited analgesic effects and antipyretic activities in animal models so this study targets to indicate the diacerein effect on nephrotoxicity induced by cisplatin in rats. Rats were distributed into four groups: normal healthy control; diacerein, which received diacerein daily by gastric gavage (50 mg/kg/day); cisplatin, which received only one intraperitoneal injection of cisplatin (6 mg/kg) and cisplatin and diacerein, which received diacerein daily after the cisplatin injection till 7th and 12th days, respectively. Diacerein treatment decreased kidney function markers so the cisplatin effect was reversed. Also, diacerein increased the renal antioxidants and decreased oxidative stress. Diacerein up-regulated Ho-1 (heme oxygenase 1), Nrf2 (Nuclear factor erythroid 2–related factor 2) and endothelial nitric oxide synthase (eNOS) genes expression, while down-regulated Bcl-2-associated X protein (Bax) gene expression. Furthermore, the renal transforming growth factor beta-1 (TGF-β1) decreased by the diacerein effect. Consequently, diacerein has a curative effect against cisplatin due to its anti-inflammatory, antioxidant, and antiapoptotic properties.
format	article
author	Nashwa Barakat Lamiaa A.A. Barakat Mahmoud M. Zakaria Salma M. Khirallah
author_facet	Nashwa Barakat Lamiaa A.A. Barakat Mahmoud M. Zakaria Salma M. Khirallah
author_sort	Nashwa Barakat
title	Diacerein ameliorates kidney injury induced by cisplatin in rats by activation of Nrf2/Ho-1 pathway and Bax down-regulation
title_short	Diacerein ameliorates kidney injury induced by cisplatin in rats by activation of Nrf2/Ho-1 pathway and Bax down-regulation
title_full	Diacerein ameliorates kidney injury induced by cisplatin in rats by activation of Nrf2/Ho-1 pathway and Bax down-regulation
title_fullStr	Diacerein ameliorates kidney injury induced by cisplatin in rats by activation of Nrf2/Ho-1 pathway and Bax down-regulation
title_full_unstemmed	Diacerein ameliorates kidney injury induced by cisplatin in rats by activation of Nrf2/Ho-1 pathway and Bax down-regulation
title_sort	diacerein ameliorates kidney injury induced by cisplatin in rats by activation of nrf2/ho-1 pathway and bax down-regulation
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/9b46c577a45547b68c168a53a77df5ae
work_keys_str_mv	AT nashwabarakat diacereinameliorateskidneyinjuryinducedbycisplatininratsbyactivationofnrf2ho1pathwayandbaxdownregulation AT lamiaaaabarakat diacereinameliorateskidneyinjuryinducedbycisplatininratsbyactivationofnrf2ho1pathwayandbaxdownregulation AT mahmoudmzakaria diacereinameliorateskidneyinjuryinducedbycisplatininratsbyactivationofnrf2ho1pathwayandbaxdownregulation AT salmamkhirallah diacereinameliorateskidneyinjuryinducedbycisplatininratsbyactivationofnrf2ho1pathwayandbaxdownregulation
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Diacerein ameliorates kidney injury induced by cisplatin in rats by activation of Nrf2/Ho-1 pathway and Bax down-regulation

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