Effects of naftopidil on double-J stent-related discomfort: a multicenter, randomized, double-blinded, placebo-controlled study

Abstract To evaluate the effect of naftopidil 75 mg once daily for ureteral double-J (DJ) stent-related discomfort after a ureteroscopic procedure using a multicenter, randomized, double-blinded, placebo-controlled study. 100 patients with indwelled retrograde DJ ureteral stents after ureteroscopic...

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Autores principales:	Jong Jin Oh, Sangchul Lee, Sung Yong Cho, Sang Wook Lee, Min Chul Cho, Woong Na, Ju Hyeon Park, Seung Bae Lee, Soyeon Ahh, Chang Wook Jeong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9b48b1116739402495065f9452bb34fc
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spelling	oai:doaj.org-article:9b48b1116739402495065f9452bb34fc2021-12-02T16:06:34ZEffects of naftopidil on double-J stent-related discomfort: a multicenter, randomized, double-blinded, placebo-controlled study10.1038/s41598-017-04505-y2045-2322https://doaj.org/article/9b48b1116739402495065f9452bb34fc2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04505-yhttps://doaj.org/toc/2045-2322Abstract To evaluate the effect of naftopidil 75 mg once daily for ureteral double-J (DJ) stent-related discomfort after a ureteroscopic procedure using a multicenter, randomized, double-blinded, placebo-controlled study. 100 patients with indwelled retrograde DJ ureteral stents after ureteroscopic stone removal or retrograde intrarenal surgery (RIRS) were randomized 1:1 to receive either placebo or naftopidil during the stenting period. At the time of stent removal, the Ureteral Stent Symptom Questionnaire (USSQ), the International Prostate Symptom Score and the total amount of used analgesics were reported. Of the 92 patients who completed the study, 49 patients were enrolled in the placebo group, and 43 patients in the naftopidil group. USSQ urinary symptom scores (30.90 vs. 29.23, p = 0.299) and USSQ body pain scores (22.28 vs. 19.58, respectively, p = 0.286) were lower in the naftopidil group than in the placebo group, but the difference was not significant. Multivariate analysis showed that the use of a ureteral access sheath during RIRS was the only significant predictor of postoperative DJ-related pain (OR = 2.736, p = 0.031). The use of naftopidil once daily did not significantly reduce DJ ureteral stent-related discomfort. Larger-scaled prospective studies should be conducted to evaluate the effects of naftopidil on DJ stent-related symptoms and surgeries.Jong Jin OhSangchul LeeSung Yong ChoSang Wook LeeMin Chul ChoWoong NaJu Hyeon ParkSeung Bae LeeSoyeon AhhChang Wook JeongNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jong Jin Oh Sangchul Lee Sung Yong Cho Sang Wook Lee Min Chul Cho Woong Na Ju Hyeon Park Seung Bae Lee Soyeon Ahh Chang Wook Jeong Effects of naftopidil on double-J stent-related discomfort: a multicenter, randomized, double-blinded, placebo-controlled study
description	Abstract To evaluate the effect of naftopidil 75 mg once daily for ureteral double-J (DJ) stent-related discomfort after a ureteroscopic procedure using a multicenter, randomized, double-blinded, placebo-controlled study. 100 patients with indwelled retrograde DJ ureteral stents after ureteroscopic stone removal or retrograde intrarenal surgery (RIRS) were randomized 1:1 to receive either placebo or naftopidil during the stenting period. At the time of stent removal, the Ureteral Stent Symptom Questionnaire (USSQ), the International Prostate Symptom Score and the total amount of used analgesics were reported. Of the 92 patients who completed the study, 49 patients were enrolled in the placebo group, and 43 patients in the naftopidil group. USSQ urinary symptom scores (30.90 vs. 29.23, p = 0.299) and USSQ body pain scores (22.28 vs. 19.58, respectively, p = 0.286) were lower in the naftopidil group than in the placebo group, but the difference was not significant. Multivariate analysis showed that the use of a ureteral access sheath during RIRS was the only significant predictor of postoperative DJ-related pain (OR = 2.736, p = 0.031). The use of naftopidil once daily did not significantly reduce DJ ureteral stent-related discomfort. Larger-scaled prospective studies should be conducted to evaluate the effects of naftopidil on DJ stent-related symptoms and surgeries.
format	article
author	Jong Jin Oh Sangchul Lee Sung Yong Cho Sang Wook Lee Min Chul Cho Woong Na Ju Hyeon Park Seung Bae Lee Soyeon Ahh Chang Wook Jeong
author_facet	Jong Jin Oh Sangchul Lee Sung Yong Cho Sang Wook Lee Min Chul Cho Woong Na Ju Hyeon Park Seung Bae Lee Soyeon Ahh Chang Wook Jeong
author_sort	Jong Jin Oh
title	Effects of naftopidil on double-J stent-related discomfort: a multicenter, randomized, double-blinded, placebo-controlled study
title_short	Effects of naftopidil on double-J stent-related discomfort: a multicenter, randomized, double-blinded, placebo-controlled study
title_full	Effects of naftopidil on double-J stent-related discomfort: a multicenter, randomized, double-blinded, placebo-controlled study
title_fullStr	Effects of naftopidil on double-J stent-related discomfort: a multicenter, randomized, double-blinded, placebo-controlled study
title_full_unstemmed	Effects of naftopidil on double-J stent-related discomfort: a multicenter, randomized, double-blinded, placebo-controlled study
title_sort	effects of naftopidil on double-j stent-related discomfort: a multicenter, randomized, double-blinded, placebo-controlled study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/9b48b1116739402495065f9452bb34fc
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Effects of naftopidil on double-J stent-related discomfort: a multicenter, randomized, double-blinded, placebo-controlled study

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