Chronic Toxoplasma gondii Infection Potentiates Parkinson’s Disease Course in Mice Model

Background: Toxoplasma gondii is a neuroinvasive protozoa pathogen that could manipulate its intermediate host's behavior. However, the possible link between T. gondii infection and the development of neurodegenerative disorders such as Parkinson’s disease (PD) has been proposed, we tested the...

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Autores principales:	Nima Firouzeh, Naser Ziaali, Vahid Sheibani, Amir Hossein Doustimotlagh, Ali Afgar, Hossein Keshavarz, Saeideh Shojaee, Reza Shafiei, Khadijeh Esmaeilpour, Zahra Babaei
Formato:	article
Lenguaje:	EN
Publicado:	Tehran University of Medical Sciences 2021
Materias:	methyl-4-phenyl-1 2 3 6-tetrahydropyridine (mptp) behavioral impairments; inflammation anxiety behaviors parkinson toxoplasma gondii Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/9b4ca62dff184d8e8fb1ede923d245f7
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spelling	oai:doaj.org-article:9b4ca62dff184d8e8fb1ede923d245f72021-11-29T07:18:55ZChronic Toxoplasma gondii Infection Potentiates Parkinson’s Disease Course in Mice Model1735-70202008-238Xhttps://doaj.org/article/9b4ca62dff184d8e8fb1ede923d245f72021-11-01T00:00:00Zhttps://ijpa.tums.ac.ir/index.php/ijpa/article/view/3323https://doaj.org/toc/1735-7020https://doaj.org/toc/2008-238XBackground: Toxoplasma gondii is a neuroinvasive protozoa pathogen that could manipulate its intermediate host's behavior. However, the possible link between T. gondii infection and the development of neurodegenerative disorders such as Parkinson’s disease (PD) has been proposed, we tested the hypothesis that in chronic toxoplasmosis neuroinflammation, and molecular mediators potentiate behavioral-cognitive impairments in BALB/c mice with PD. Methods: To establish chronic toxoplasmosis by Tehran strain, cysts of T. gondii were injected intraperitoneally into BALB/c mice in Kerman, Iran in 2019. To induce the PD model, mice (BALB/c) were treated with Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The behavioral experiments such as anxiety and motor coordination were performed using the Open field and Rotarod tests. Additionally, we investigated the contribution of Toxoplasma-induced neuroinflammation, and behavioral-cognitive impairments in the PD mice model. Results: Chronic toxoplasmosis caused PD-like symptoms and induced various behavioral changes in infected BALB/c mice. In T. gondii infected+MPTP treated group, T. gondii infection could potentiate PD in infected mice receiving MPTP and caused remarkable dysfunction in motor coordination and change in anxiety and depression-like behaviors similar or more severe than PD group. Conclusion: Chronic T. gondii infection exacerbates pathological progression of PD in BALB/c mice brain by promoting neuroinflammation, and behavioral changes establishing.Nima FirouzehNaser ZiaaliVahid SheibaniAmir Hossein DoustimotlaghAli AfgarHossein KeshavarzSaeideh ShojaeeReza ShafieiKhadijeh EsmaeilpourZahra BabaeiTehran University of Medical Sciencesarticlemethyl-4-phenyl-1236-tetrahydropyridine (mptp)behavioral impairments;inflammationanxiety behaviorsparkinsontoxoplasma gondiiInfectious and parasitic diseasesRC109-216ENIranian Journal of Parasitology, Vol 16, Iss 4, Pp 527-537 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	methyl-4-phenyl-1 2 3 6-tetrahydropyridine (mptp) behavioral impairments; inflammation anxiety behaviors parkinson toxoplasma gondii Infectious and parasitic diseases RC109-216
spellingShingle	methyl-4-phenyl-1 2 3 6-tetrahydropyridine (mptp) behavioral impairments; inflammation anxiety behaviors parkinson toxoplasma gondii Infectious and parasitic diseases RC109-216 Nima Firouzeh Naser Ziaali Vahid Sheibani Amir Hossein Doustimotlagh Ali Afgar Hossein Keshavarz Saeideh Shojaee Reza Shafiei Khadijeh Esmaeilpour Zahra Babaei Chronic Toxoplasma gondii Infection Potentiates Parkinson’s Disease Course in Mice Model
description	Background: Toxoplasma gondii is a neuroinvasive protozoa pathogen that could manipulate its intermediate host's behavior. However, the possible link between T. gondii infection and the development of neurodegenerative disorders such as Parkinson’s disease (PD) has been proposed, we tested the hypothesis that in chronic toxoplasmosis neuroinflammation, and molecular mediators potentiate behavioral-cognitive impairments in BALB/c mice with PD. Methods: To establish chronic toxoplasmosis by Tehran strain, cysts of T. gondii were injected intraperitoneally into BALB/c mice in Kerman, Iran in 2019. To induce the PD model, mice (BALB/c) were treated with Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The behavioral experiments such as anxiety and motor coordination were performed using the Open field and Rotarod tests. Additionally, we investigated the contribution of Toxoplasma-induced neuroinflammation, and behavioral-cognitive impairments in the PD mice model. Results: Chronic toxoplasmosis caused PD-like symptoms and induced various behavioral changes in infected BALB/c mice. In T. gondii infected+MPTP treated group, T. gondii infection could potentiate PD in infected mice receiving MPTP and caused remarkable dysfunction in motor coordination and change in anxiety and depression-like behaviors similar or more severe than PD group. Conclusion: Chronic T. gondii infection exacerbates pathological progression of PD in BALB/c mice brain by promoting neuroinflammation, and behavioral changes establishing.
format	article
author	Nima Firouzeh Naser Ziaali Vahid Sheibani Amir Hossein Doustimotlagh Ali Afgar Hossein Keshavarz Saeideh Shojaee Reza Shafiei Khadijeh Esmaeilpour Zahra Babaei
author_facet	Nima Firouzeh Naser Ziaali Vahid Sheibani Amir Hossein Doustimotlagh Ali Afgar Hossein Keshavarz Saeideh Shojaee Reza Shafiei Khadijeh Esmaeilpour Zahra Babaei
author_sort	Nima Firouzeh
title	Chronic Toxoplasma gondii Infection Potentiates Parkinson’s Disease Course in Mice Model
title_short	Chronic Toxoplasma gondii Infection Potentiates Parkinson’s Disease Course in Mice Model
title_full	Chronic Toxoplasma gondii Infection Potentiates Parkinson’s Disease Course in Mice Model
title_fullStr	Chronic Toxoplasma gondii Infection Potentiates Parkinson’s Disease Course in Mice Model
title_full_unstemmed	Chronic Toxoplasma gondii Infection Potentiates Parkinson’s Disease Course in Mice Model
title_sort	chronic toxoplasma gondii infection potentiates parkinson’s disease course in mice model
publisher	Tehran University of Medical Sciences
publishDate	2021
url	https://doaj.org/article/9b4ca62dff184d8e8fb1ede923d245f7
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Chronic Toxoplasma gondii Infection Potentiates Parkinson’s Disease Course in Mice Model

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