Everyday cognition scales are related to cognitive function in the early stage of probable Alzheimer’s disease and FDG-PET findings

Abstract We applied the Everyday Cognition (ECog) scale in normal aging adults and patients with Alzheimer’s disease (AD) to investigate associations between neuropsychological tests and neuroimaging markers. A total of 160 normal aging adults and 40 patients with the early stage of probable AD were...

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Autores principales:	Jung-Lung Hsu, Wen-Chuin Hsu, Chiung-Chih Chang, Kun-Ju Lin, Ing-Tsung Hsiao, Yen-Chun Fan, Chyi-Huey Bai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9b4cf3f244c04d5ca7a44c46616ccd4a
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spelling	oai:doaj.org-article:9b4cf3f244c04d5ca7a44c46616ccd4a2021-12-02T12:32:04ZEveryday cognition scales are related to cognitive function in the early stage of probable Alzheimer’s disease and FDG-PET findings10.1038/s41598-017-01193-62045-2322https://doaj.org/article/9b4cf3f244c04d5ca7a44c46616ccd4a2017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01193-6https://doaj.org/toc/2045-2322Abstract We applied the Everyday Cognition (ECog) scale in normal aging adults and patients with Alzheimer’s disease (AD) to investigate associations between neuropsychological tests and neuroimaging markers. A total of 160 normal aging adults and 40 patients with the early stage of probable AD were included. Neuropsychological performance was assessed using the Consortium to Establish a Registry for Alzheimer’s Disease Neuropsychological Assessment Battery (CERAD-NAB). 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) scans were used to measure AD-related hypometabolism. Nonparametric Spearman correlation analysis was used to study associations between ECog and z-transformed total CERAD-NAB scores in both groups. The results revealed a significant correlation between total ECog and CERAD-NAB scores (rho = −0.28, p < 0.01), and category verbal fluency test with the executive domain of the ECog scale (rho = −0.20, p < 0.01). The CERAD-NAB scores were also significantly correlated with AD-related hypometabolism (rho = −0.49, p < 0.01). The memory domain of the ECog scale was significantly correlated with FDG uptake in the angular gyrus and posterior cingulum gyrus (rho = −0.41 and −0.46, P < 0.01). In conclusion, both total and memory domain ECog scores were correlated with the neuropsychological tests and neuroimaging biomarkers.Jung-Lung HsuWen-Chuin HsuChiung-Chih ChangKun-Ju LinIng-Tsung HsiaoYen-Chun FanChyi-Huey BaiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jung-Lung Hsu Wen-Chuin Hsu Chiung-Chih Chang Kun-Ju Lin Ing-Tsung Hsiao Yen-Chun Fan Chyi-Huey Bai Everyday cognition scales are related to cognitive function in the early stage of probable Alzheimer’s disease and FDG-PET findings
description	Abstract We applied the Everyday Cognition (ECog) scale in normal aging adults and patients with Alzheimer’s disease (AD) to investigate associations between neuropsychological tests and neuroimaging markers. A total of 160 normal aging adults and 40 patients with the early stage of probable AD were included. Neuropsychological performance was assessed using the Consortium to Establish a Registry for Alzheimer’s Disease Neuropsychological Assessment Battery (CERAD-NAB). 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) scans were used to measure AD-related hypometabolism. Nonparametric Spearman correlation analysis was used to study associations between ECog and z-transformed total CERAD-NAB scores in both groups. The results revealed a significant correlation between total ECog and CERAD-NAB scores (rho = −0.28, p < 0.01), and category verbal fluency test with the executive domain of the ECog scale (rho = −0.20, p < 0.01). The CERAD-NAB scores were also significantly correlated with AD-related hypometabolism (rho = −0.49, p < 0.01). The memory domain of the ECog scale was significantly correlated with FDG uptake in the angular gyrus and posterior cingulum gyrus (rho = −0.41 and −0.46, P < 0.01). In conclusion, both total and memory domain ECog scores were correlated with the neuropsychological tests and neuroimaging biomarkers.
format	article
author	Jung-Lung Hsu Wen-Chuin Hsu Chiung-Chih Chang Kun-Ju Lin Ing-Tsung Hsiao Yen-Chun Fan Chyi-Huey Bai
author_facet	Jung-Lung Hsu Wen-Chuin Hsu Chiung-Chih Chang Kun-Ju Lin Ing-Tsung Hsiao Yen-Chun Fan Chyi-Huey Bai
author_sort	Jung-Lung Hsu
title	Everyday cognition scales are related to cognitive function in the early stage of probable Alzheimer’s disease and FDG-PET findings
title_short	Everyday cognition scales are related to cognitive function in the early stage of probable Alzheimer’s disease and FDG-PET findings
title_full	Everyday cognition scales are related to cognitive function in the early stage of probable Alzheimer’s disease and FDG-PET findings
title_fullStr	Everyday cognition scales are related to cognitive function in the early stage of probable Alzheimer’s disease and FDG-PET findings
title_full_unstemmed	Everyday cognition scales are related to cognitive function in the early stage of probable Alzheimer’s disease and FDG-PET findings
title_sort	everyday cognition scales are related to cognitive function in the early stage of probable alzheimer’s disease and fdg-pet findings
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/9b4cf3f244c04d5ca7a44c46616ccd4a
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Everyday cognition scales are related to cognitive function in the early stage of probable Alzheimer’s disease and FDG-PET findings

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