An Overview of Glycosylation and its Impact on Cardiovascular Health and Disease
The cardiovascular system is a complex and well-organized system in which glycosylation plays a vital role. The heart and vascular wall cells are constituted by an array of specific receptors; most of them are N- glycosylated and mucin-type O-glycosylated. There are also intracellular signaling path...
Guardado en:
| Autores principales: | , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Frontiers Media S.A.
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/9b4d30e6ee3648058d080a9de5d9f0f9 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:9b4d30e6ee3648058d080a9de5d9f0f9 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:9b4d30e6ee3648058d080a9de5d9f0f92021-11-16T06:40:38ZAn Overview of Glycosylation and its Impact on Cardiovascular Health and Disease2296-889X10.3389/fmolb.2021.751637https://doaj.org/article/9b4d30e6ee3648058d080a9de5d9f0f92021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmolb.2021.751637/fullhttps://doaj.org/toc/2296-889XThe cardiovascular system is a complex and well-organized system in which glycosylation plays a vital role. The heart and vascular wall cells are constituted by an array of specific receptors; most of them are N- glycosylated and mucin-type O-glycosylated. There are also intracellular signaling pathways regulated by different post-translational modifications, including O-GlcNAcylation, which promote adequate responses to extracellular stimuli and signaling transduction. Herein, we provide an overview of N-glycosylation and O-glycosylation, including O-GlcNAcylation, and their role at different levels such as reception of signal, signal transduction, and exogenous molecules or agonists, which stimulate the heart and vascular wall cells with effects in different conditions, like the physiological status, ischemia/reperfusion, exercise, or during low-grade inflammation in diabetes and aging. Furthermore, mutations of glycosyltransferases and receptors are associated with development of cardiovascular diseases. The knowledge on glycosylation and its effects could be considered biochemical markers and might be useful as a therapeutic tool to control cardiovascular diseases.Karen Julissa Loaeza-ReyesKaren Julissa Loaeza-ReyesEdgar ZentenoAdriana Moreno-RodríguezRafael Torres-RosasLiliana Argueta-FigueroaLiliana Argueta-FigueroaRoberta Salinas-MarínLizet Monserrat Castillo-RealSocorro Pina-CansecoYobana Pérez CerveraYobana Pérez CerveraFrontiers Media S.A.articleglycosylationO-GlcNAcylationN-glycosylationcardioprotectivehypertrophyO-glycosylationBiology (General)QH301-705.5ENFrontiers in Molecular Biosciences, Vol 8 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
glycosylation O-GlcNAcylation N-glycosylation cardioprotective hypertrophy O-glycosylation Biology (General) QH301-705.5 |
| spellingShingle |
glycosylation O-GlcNAcylation N-glycosylation cardioprotective hypertrophy O-glycosylation Biology (General) QH301-705.5 Karen Julissa Loaeza-Reyes Karen Julissa Loaeza-Reyes Edgar Zenteno Adriana Moreno-Rodríguez Rafael Torres-Rosas Liliana Argueta-Figueroa Liliana Argueta-Figueroa Roberta Salinas-Marín Lizet Monserrat Castillo-Real Socorro Pina-Canseco Yobana Pérez Cervera Yobana Pérez Cervera An Overview of Glycosylation and its Impact on Cardiovascular Health and Disease |
| description |
The cardiovascular system is a complex and well-organized system in which glycosylation plays a vital role. The heart and vascular wall cells are constituted by an array of specific receptors; most of them are N- glycosylated and mucin-type O-glycosylated. There are also intracellular signaling pathways regulated by different post-translational modifications, including O-GlcNAcylation, which promote adequate responses to extracellular stimuli and signaling transduction. Herein, we provide an overview of N-glycosylation and O-glycosylation, including O-GlcNAcylation, and their role at different levels such as reception of signal, signal transduction, and exogenous molecules or agonists, which stimulate the heart and vascular wall cells with effects in different conditions, like the physiological status, ischemia/reperfusion, exercise, or during low-grade inflammation in diabetes and aging. Furthermore, mutations of glycosyltransferases and receptors are associated with development of cardiovascular diseases. The knowledge on glycosylation and its effects could be considered biochemical markers and might be useful as a therapeutic tool to control cardiovascular diseases. |
| format |
article |
| author |
Karen Julissa Loaeza-Reyes Karen Julissa Loaeza-Reyes Edgar Zenteno Adriana Moreno-Rodríguez Rafael Torres-Rosas Liliana Argueta-Figueroa Liliana Argueta-Figueroa Roberta Salinas-Marín Lizet Monserrat Castillo-Real Socorro Pina-Canseco Yobana Pérez Cervera Yobana Pérez Cervera |
| author_facet |
Karen Julissa Loaeza-Reyes Karen Julissa Loaeza-Reyes Edgar Zenteno Adriana Moreno-Rodríguez Rafael Torres-Rosas Liliana Argueta-Figueroa Liliana Argueta-Figueroa Roberta Salinas-Marín Lizet Monserrat Castillo-Real Socorro Pina-Canseco Yobana Pérez Cervera Yobana Pérez Cervera |
| author_sort |
Karen Julissa Loaeza-Reyes |
| title |
An Overview of Glycosylation and its Impact on Cardiovascular Health and Disease |
| title_short |
An Overview of Glycosylation and its Impact on Cardiovascular Health and Disease |
| title_full |
An Overview of Glycosylation and its Impact on Cardiovascular Health and Disease |
| title_fullStr |
An Overview of Glycosylation and its Impact on Cardiovascular Health and Disease |
| title_full_unstemmed |
An Overview of Glycosylation and its Impact on Cardiovascular Health and Disease |
| title_sort |
overview of glycosylation and its impact on cardiovascular health and disease |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/9b4d30e6ee3648058d080a9de5d9f0f9 |
| work_keys_str_mv |
AT karenjulissaloaezareyes anoverviewofglycosylationanditsimpactoncardiovascularhealthanddisease AT karenjulissaloaezareyes anoverviewofglycosylationanditsimpactoncardiovascularhealthanddisease AT edgarzenteno anoverviewofglycosylationanditsimpactoncardiovascularhealthanddisease AT adrianamorenorodriguez anoverviewofglycosylationanditsimpactoncardiovascularhealthanddisease AT rafaeltorresrosas anoverviewofglycosylationanditsimpactoncardiovascularhealthanddisease AT lilianaarguetafigueroa anoverviewofglycosylationanditsimpactoncardiovascularhealthanddisease AT lilianaarguetafigueroa anoverviewofglycosylationanditsimpactoncardiovascularhealthanddisease AT robertasalinasmarin anoverviewofglycosylationanditsimpactoncardiovascularhealthanddisease AT lizetmonserratcastilloreal anoverviewofglycosylationanditsimpactoncardiovascularhealthanddisease AT socorropinacanseco anoverviewofglycosylationanditsimpactoncardiovascularhealthanddisease AT yobanaperezcervera anoverviewofglycosylationanditsimpactoncardiovascularhealthanddisease AT yobanaperezcervera anoverviewofglycosylationanditsimpactoncardiovascularhealthanddisease AT karenjulissaloaezareyes overviewofglycosylationanditsimpactoncardiovascularhealthanddisease AT karenjulissaloaezareyes overviewofglycosylationanditsimpactoncardiovascularhealthanddisease AT edgarzenteno overviewofglycosylationanditsimpactoncardiovascularhealthanddisease AT adrianamorenorodriguez overviewofglycosylationanditsimpactoncardiovascularhealthanddisease AT rafaeltorresrosas overviewofglycosylationanditsimpactoncardiovascularhealthanddisease AT lilianaarguetafigueroa overviewofglycosylationanditsimpactoncardiovascularhealthanddisease AT lilianaarguetafigueroa overviewofglycosylationanditsimpactoncardiovascularhealthanddisease AT robertasalinasmarin overviewofglycosylationanditsimpactoncardiovascularhealthanddisease AT lizetmonserratcastilloreal overviewofglycosylationanditsimpactoncardiovascularhealthanddisease AT socorropinacanseco overviewofglycosylationanditsimpactoncardiovascularhealthanddisease AT yobanaperezcervera overviewofglycosylationanditsimpactoncardiovascularhealthanddisease AT yobanaperezcervera overviewofglycosylationanditsimpactoncardiovascularhealthanddisease |
| _version_ |
1718426683656110080 |