Antibodies in children with malaria to PfEMP1, RIFIN and SURFIN expressed at the Plasmodium falciparum parasitized red blood cell surface

Abstract Naturally acquired antibodies to proteins expressed on the Plasmodium falciparum parasitized red blood cell (pRBC) surface steer the course of a malaria infection by reducing sequestration and stimulating phagocytosis of pRBC. Here we have studied a selection of proteins representing three...

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Autores principales:	Maria del Pilar Quintana, Jun-Hong Ch’ng, Kirsten Moll, Arash Zandian, Peter Nilsson, Zulkarnain Md Idris, Somporn Saiwaew, Ulrika Qundos, Mats Wahlgren
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9b4fd872e3274896a2e86a785a9a8e51
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spelling	oai:doaj.org-article:9b4fd872e3274896a2e86a785a9a8e512021-12-02T15:07:58ZAntibodies in children with malaria to PfEMP1, RIFIN and SURFIN expressed at the Plasmodium falciparum parasitized red blood cell surface10.1038/s41598-018-21026-42045-2322https://doaj.org/article/9b4fd872e3274896a2e86a785a9a8e512018-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-21026-4https://doaj.org/toc/2045-2322Abstract Naturally acquired antibodies to proteins expressed on the Plasmodium falciparum parasitized red blood cell (pRBC) surface steer the course of a malaria infection by reducing sequestration and stimulating phagocytosis of pRBC. Here we have studied a selection of proteins representing three different parasite gene families employing a well-characterized parasite with a severe malaria phenotype (FCR3S1.2). The presence of naturally acquired antibodies, impact on rosetting rate, surface reactivity and opsonization for phagocytosis in relation to different blood groups of the ABO system were assessed in a set of sera from children with mild or complicated malaria from an endemic area. We show that the naturally acquired immune responses, developed during malaria natural infection, have limited access to the pRBCs inside a blood group A rosette. The data also indicate that SURFIN4.2 may have a function at the pRBC surface, particularly during rosette formation, this role however needs to be further validated. Our results also indicate epitopes differentially recognized by rosette-disrupting antibodies on a peptide array. Antibodies towards parasite-derived proteins such as PfEMP1, RIFIN and SURFIN in combination with host factors, essentially the ABO blood group of a malaria patient, are suggested to determine the outcome of a malaria infection.Maria del Pilar QuintanaJun-Hong Ch’ngKirsten MollArash ZandianPeter NilssonZulkarnain Md IdrisSomporn SaiwaewUlrika QundosMats WahlgrenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maria del Pilar Quintana Jun-Hong Ch’ng Kirsten Moll Arash Zandian Peter Nilsson Zulkarnain Md Idris Somporn Saiwaew Ulrika Qundos Mats Wahlgren Antibodies in children with malaria to PfEMP1, RIFIN and SURFIN expressed at the Plasmodium falciparum parasitized red blood cell surface
description	Abstract Naturally acquired antibodies to proteins expressed on the Plasmodium falciparum parasitized red blood cell (pRBC) surface steer the course of a malaria infection by reducing sequestration and stimulating phagocytosis of pRBC. Here we have studied a selection of proteins representing three different parasite gene families employing a well-characterized parasite with a severe malaria phenotype (FCR3S1.2). The presence of naturally acquired antibodies, impact on rosetting rate, surface reactivity and opsonization for phagocytosis in relation to different blood groups of the ABO system were assessed in a set of sera from children with mild or complicated malaria from an endemic area. We show that the naturally acquired immune responses, developed during malaria natural infection, have limited access to the pRBCs inside a blood group A rosette. The data also indicate that SURFIN4.2 may have a function at the pRBC surface, particularly during rosette formation, this role however needs to be further validated. Our results also indicate epitopes differentially recognized by rosette-disrupting antibodies on a peptide array. Antibodies towards parasite-derived proteins such as PfEMP1, RIFIN and SURFIN in combination with host factors, essentially the ABO blood group of a malaria patient, are suggested to determine the outcome of a malaria infection.
format	article
author	Maria del Pilar Quintana Jun-Hong Ch’ng Kirsten Moll Arash Zandian Peter Nilsson Zulkarnain Md Idris Somporn Saiwaew Ulrika Qundos Mats Wahlgren
author_facet	Maria del Pilar Quintana Jun-Hong Ch’ng Kirsten Moll Arash Zandian Peter Nilsson Zulkarnain Md Idris Somporn Saiwaew Ulrika Qundos Mats Wahlgren
author_sort	Maria del Pilar Quintana
title	Antibodies in children with malaria to PfEMP1, RIFIN and SURFIN expressed at the Plasmodium falciparum parasitized red blood cell surface
title_short	Antibodies in children with malaria to PfEMP1, RIFIN and SURFIN expressed at the Plasmodium falciparum parasitized red blood cell surface
title_full	Antibodies in children with malaria to PfEMP1, RIFIN and SURFIN expressed at the Plasmodium falciparum parasitized red blood cell surface
title_fullStr	Antibodies in children with malaria to PfEMP1, RIFIN and SURFIN expressed at the Plasmodium falciparum parasitized red blood cell surface
title_full_unstemmed	Antibodies in children with malaria to PfEMP1, RIFIN and SURFIN expressed at the Plasmodium falciparum parasitized red blood cell surface
title_sort	antibodies in children with malaria to pfemp1, rifin and surfin expressed at the plasmodium falciparum parasitized red blood cell surface
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/9b4fd872e3274896a2e86a785a9a8e51
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Antibodies in children with malaria to PfEMP1, RIFIN and SURFIN expressed at the Plasmodium falciparum parasitized red blood cell surface

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