Pilot Trial of Neuromuscular Stimulation in Human Subjects with Chronic Venous Disease

Katherine J Williams, Hayley M Moore, Mary Ellis, Alun H Davies Academic Section of Vascular Surgery, Imperial College London, London, UKCorrespondence: Alun H DaviesAcademic Department of Vascular Surgery, 4th Floor, Charing Cross Hospital, Fulham Palace Road, London, W6 8RF, UKTel +44 20 3311 7320...

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Autores principales:	Williams KJ, Moore HM, Ellis M, Davies AH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	neuromuscular electrical stimulation venous disease venous insufficiency Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/9b54e64c33e3425a98292591cb78cffd
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spelling	oai:doaj.org-article:9b54e64c33e3425a98292591cb78cffd2021-11-30T18:50:37ZPilot Trial of Neuromuscular Stimulation in Human Subjects with Chronic Venous Disease1178-2048https://doaj.org/article/9b54e64c33e3425a98292591cb78cffd2021-12-01T00:00:00Zhttps://www.dovepress.com/pilot-trial-of-neuromuscular-stimulation-in-human-subjects-with-chroni-peer-reviewed-fulltext-article-VHRMhttps://doaj.org/toc/1178-2048Katherine J Williams, Hayley M Moore, Mary Ellis, Alun H Davies Academic Section of Vascular Surgery, Imperial College London, London, UKCorrespondence: Alun H DaviesAcademic Department of Vascular Surgery, 4th Floor, Charing Cross Hospital, Fulham Palace Road, London, W6 8RF, UKTel +44 20 3311 7320Email a.h.davies@ic.ac.ukIntroduction: Neuromuscular stimulation (NMES) has been shown to improve peripheral blood flow in healthy people. We investigated the effect of bilateral leg NMES on the symptoms of chronic venous disease.Methods: Forty subjects were recruited from four groups: healthy, superficial insufficiency, deep insufficiency, and deep obstruction. Haemodynamic venous measurements were taken from the right femoral vein with ultrasound, laser Doppler fluximetry from the left hand and foot. Devices were then worn for 4– 6 hours per day, for 6 weeks. Haemodynamic measurements were repeated at week 6. Quality of life questionnaires were taken at week 0, 6 and 8.Results: The mean age was 48.7, BMI 28.6kg/m2, and maximum calf circumference 39.0 cm. Twenty-four subjects were men. NMES increased femoral vein peak velocity, TAMV and volume flow by 55%, 20%, 36% at 20 minutes (all p< 0.05), which was enhanced at week 6 (PV and TAMV p< 0.05). Mean increases in arm and leg fluximetry were 71% and 194% (both p< 0.01). Leg swelling was reduced by mean 252.7 mL (13%, p< 0.05) overall; 338.9 mL (16%, p< 0.05) in venous disease. For those with venous pathology, scores for disease specific and generic quality of life questionnaires improved. Those with C4-6 disease benefitted the most, with improvements in VDS score of 1, AVVQ of 6, and SF-12 of 10.Conclusion: NMES improves venous haemodynamic parameters in chronic venous disease, which is enhanced by regular use. NMES reduces leg oedema, improves blood supply to the skin of the foot, and may positively affect quality of life.Clinical Trials: This trial was registered with www.clinicaltrials.org.uk (NCT02137499).Keywords: neuromuscular, electrical, stimulation, venous disease, venous insufficiencyWilliams KJMoore HMEllis MDavies AHDove Medical Pressarticleneuromuscularelectricalstimulationvenous diseasevenous insufficiencyDiseases of the circulatory (Cardiovascular) systemRC666-701ENVascular Health and Risk Management, Vol Volume 17, Pp 771-778 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	neuromuscular electrical stimulation venous disease venous insufficiency Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	neuromuscular electrical stimulation venous disease venous insufficiency Diseases of the circulatory (Cardiovascular) system RC666-701 Williams KJ Moore HM Ellis M Davies AH Pilot Trial of Neuromuscular Stimulation in Human Subjects with Chronic Venous Disease
description	Katherine J Williams, Hayley M Moore, Mary Ellis, Alun H Davies Academic Section of Vascular Surgery, Imperial College London, London, UKCorrespondence: Alun H DaviesAcademic Department of Vascular Surgery, 4th Floor, Charing Cross Hospital, Fulham Palace Road, London, W6 8RF, UKTel +44 20 3311 7320Email a.h.davies@ic.ac.ukIntroduction: Neuromuscular stimulation (NMES) has been shown to improve peripheral blood flow in healthy people. We investigated the effect of bilateral leg NMES on the symptoms of chronic venous disease.Methods: Forty subjects were recruited from four groups: healthy, superficial insufficiency, deep insufficiency, and deep obstruction. Haemodynamic venous measurements were taken from the right femoral vein with ultrasound, laser Doppler fluximetry from the left hand and foot. Devices were then worn for 4– 6 hours per day, for 6 weeks. Haemodynamic measurements were repeated at week 6. Quality of life questionnaires were taken at week 0, 6 and 8.Results: The mean age was 48.7, BMI 28.6kg/m2, and maximum calf circumference 39.0 cm. Twenty-four subjects were men. NMES increased femoral vein peak velocity, TAMV and volume flow by 55%, 20%, 36% at 20 minutes (all p< 0.05), which was enhanced at week 6 (PV and TAMV p< 0.05). Mean increases in arm and leg fluximetry were 71% and 194% (both p< 0.01). Leg swelling was reduced by mean 252.7 mL (13%, p< 0.05) overall; 338.9 mL (16%, p< 0.05) in venous disease. For those with venous pathology, scores for disease specific and generic quality of life questionnaires improved. Those with C4-6 disease benefitted the most, with improvements in VDS score of 1, AVVQ of 6, and SF-12 of 10.Conclusion: NMES improves venous haemodynamic parameters in chronic venous disease, which is enhanced by regular use. NMES reduces leg oedema, improves blood supply to the skin of the foot, and may positively affect quality of life.Clinical Trials: This trial was registered with www.clinicaltrials.org.uk (NCT02137499).Keywords: neuromuscular, electrical, stimulation, venous disease, venous insufficiency
format	article
author	Williams KJ Moore HM Ellis M Davies AH
author_facet	Williams KJ Moore HM Ellis M Davies AH
author_sort	Williams KJ
title	Pilot Trial of Neuromuscular Stimulation in Human Subjects with Chronic Venous Disease
title_short	Pilot Trial of Neuromuscular Stimulation in Human Subjects with Chronic Venous Disease
title_full	Pilot Trial of Neuromuscular Stimulation in Human Subjects with Chronic Venous Disease
title_fullStr	Pilot Trial of Neuromuscular Stimulation in Human Subjects with Chronic Venous Disease
title_full_unstemmed	Pilot Trial of Neuromuscular Stimulation in Human Subjects with Chronic Venous Disease
title_sort	pilot trial of neuromuscular stimulation in human subjects with chronic venous disease
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/9b54e64c33e3425a98292591cb78cffd
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Pilot Trial of Neuromuscular Stimulation in Human Subjects with Chronic Venous Disease

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