Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a

Complement C3a is an important protein in innate and adaptive immunity, but its roles in vivo are unclear. Here the authors develop novel chemical agonists and antagonists for the C3a receptor, and show that they modulate mast cell degranulation and inflammation in a rat paw edema model

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Autores principales:	Rink-Jan Lohman, Johan K. Hamidon, Robert C. Reid, Jessica A. Rowley, Mei-Kwan Yau, Maria A. Halili, Daniel S. Nielsen, Junxian Lim, Kai-Chen Wu, Zhixuan Loh, Anh Do, Jacky Y. Suen, Abishek Iyer, David P. Fairlie
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9b55fdd2b33140c08bc5b8dacdba336c
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spelling	oai:doaj.org-article:9b55fdd2b33140c08bc5b8dacdba336c2021-12-02T14:42:27ZExploiting a novel conformational switch to control innate immunity mediated by complement protein C3a10.1038/s41467-017-00414-w2041-1723https://doaj.org/article/9b55fdd2b33140c08bc5b8dacdba336c2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00414-whttps://doaj.org/toc/2041-1723Complement C3a is an important protein in innate and adaptive immunity, but its roles in vivo are unclear. Here the authors develop novel chemical agonists and antagonists for the C3a receptor, and show that they modulate mast cell degranulation and inflammation in a rat paw edema modelRink-Jan LohmanJohan K. HamidonRobert C. ReidJessica A. RowleyMei-Kwan YauMaria A. HaliliDaniel S. NielsenJunxian LimKai-Chen WuZhixuan LohAnh DoJacky Y. SuenAbishek IyerDavid P. FairlieNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rink-Jan Lohman Johan K. Hamidon Robert C. Reid Jessica A. Rowley Mei-Kwan Yau Maria A. Halili Daniel S. Nielsen Junxian Lim Kai-Chen Wu Zhixuan Loh Anh Do Jacky Y. Suen Abishek Iyer David P. Fairlie Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a
description	Complement C3a is an important protein in innate and adaptive immunity, but its roles in vivo are unclear. Here the authors develop novel chemical agonists and antagonists for the C3a receptor, and show that they modulate mast cell degranulation and inflammation in a rat paw edema model
format	article
author	Rink-Jan Lohman Johan K. Hamidon Robert C. Reid Jessica A. Rowley Mei-Kwan Yau Maria A. Halili Daniel S. Nielsen Junxian Lim Kai-Chen Wu Zhixuan Loh Anh Do Jacky Y. Suen Abishek Iyer David P. Fairlie
author_facet	Rink-Jan Lohman Johan K. Hamidon Robert C. Reid Jessica A. Rowley Mei-Kwan Yau Maria A. Halili Daniel S. Nielsen Junxian Lim Kai-Chen Wu Zhixuan Loh Anh Do Jacky Y. Suen Abishek Iyer David P. Fairlie
author_sort	Rink-Jan Lohman
title	Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a
title_short	Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a
title_full	Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a
title_fullStr	Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a
title_full_unstemmed	Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a
title_sort	exploiting a novel conformational switch to control innate immunity mediated by complement protein c3a
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/9b55fdd2b33140c08bc5b8dacdba336c
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Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a

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