Association between the SLC6A4 gene and schizophrenia: an updated meta-analysis

Feng-ling Xu, Bao-jie Wang, Jun Yao School of Forensic Medicine, China Medical University, Shenyang 110122, People’s Republic of China Background: In order to explore the association between the SLC6A4 gene and the risk of schizophrenia, an updated meta-analysis was conducted using a tot...

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Autores principales:	Xu F, Wang B, Yao J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	SLC6A4 gene schizophrenia meta-analysis polymorphism Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/9b56b57bb99949e29182754a63692da3
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spelling	oai:doaj.org-article:9b56b57bb99949e29182754a63692da32021-12-02T07:26:28ZAssociation between the SLC6A4 gene and schizophrenia: an updated meta-analysis1178-2021https://doaj.org/article/9b56b57bb99949e29182754a63692da32018-12-01T00:00:00Zhttps://www.dovepress.com/association-between-the-slc6a4-gene-and-schizophrenia-an-updated-meta--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Feng-ling Xu, Bao-jie Wang, Jun Yao School of Forensic Medicine, China Medical University, Shenyang 110122, People’s Republic of China Background: In order to explore the association between the SLC6A4 gene and the risk of schizophrenia, an updated meta-analysis was conducted using a total of 46 scientific articles. Methods: Through a literature search, papers studied included 35 articles on serotonin-transporter-linked polymorphic region (5-HTTLPR) with 8,752 cases and 10,610 controls, 17 articles on second intron variable number of tandem repeats with 7,284 cases and 8,544 controls, four studies on rs1042173 with 1,351 cases and 2,101 controls, and four studies on rs140700 with 1,770 cases and 2,386 controls. Pooled, subgroup, and sensitivity analyses were performed, and the results were visualized by forest and funnel plots. Results: An association between 5-HTTLPR and the risk of schizophrenia was not found, except for an Indian subgroup analysis (Pz=0.014, OR =1.749, 95% CI =1.120–2.731). A 10 repeats/12 repeats (10R/12R) genotype was a protective factor against schizophrenia (Pz=0.020, OR =0.789, 95% CI =0.646–0.963), but a 12R/12R genotype was a risk factor for schizophrenia (Pz=0.004, OR =1.936, 95% CI =1.238–3.029) in the pooled analyses. In Caucasians, a GG genotype of rs1042173 may be a risk factor for schizophrenia (Pz=0.006, OR =1.299, 95% CI =1.079–1.565). No association was found between rs140700 and the risk for schizophrenia. Conclusion: Through meta-analysis, we were able to gain insight into previously reported associations between SLC6A4 polymorphism and schizophrenia. Keywords: SLC6A4, gene, schizophrenia, meta-analysis, polymorphismXu FWang BYao JDove Medical PressarticleSLC6A4 geneschizophreniameta-analysispolymorphismNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 143-155 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	SLC6A4 gene schizophrenia meta-analysis polymorphism Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	SLC6A4 gene schizophrenia meta-analysis polymorphism Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Xu F Wang B Yao J Association between the SLC6A4 gene and schizophrenia: an updated meta-analysis
description	Feng-ling Xu, Bao-jie Wang, Jun Yao School of Forensic Medicine, China Medical University, Shenyang 110122, People’s Republic of China Background: In order to explore the association between the SLC6A4 gene and the risk of schizophrenia, an updated meta-analysis was conducted using a total of 46 scientific articles. Methods: Through a literature search, papers studied included 35 articles on serotonin-transporter-linked polymorphic region (5-HTTLPR) with 8,752 cases and 10,610 controls, 17 articles on second intron variable number of tandem repeats with 7,284 cases and 8,544 controls, four studies on rs1042173 with 1,351 cases and 2,101 controls, and four studies on rs140700 with 1,770 cases and 2,386 controls. Pooled, subgroup, and sensitivity analyses were performed, and the results were visualized by forest and funnel plots. Results: An association between 5-HTTLPR and the risk of schizophrenia was not found, except for an Indian subgroup analysis (Pz=0.014, OR =1.749, 95% CI =1.120–2.731). A 10 repeats/12 repeats (10R/12R) genotype was a protective factor against schizophrenia (Pz=0.020, OR =0.789, 95% CI =0.646–0.963), but a 12R/12R genotype was a risk factor for schizophrenia (Pz=0.004, OR =1.936, 95% CI =1.238–3.029) in the pooled analyses. In Caucasians, a GG genotype of rs1042173 may be a risk factor for schizophrenia (Pz=0.006, OR =1.299, 95% CI =1.079–1.565). No association was found between rs140700 and the risk for schizophrenia. Conclusion: Through meta-analysis, we were able to gain insight into previously reported associations between SLC6A4 polymorphism and schizophrenia. Keywords: SLC6A4, gene, schizophrenia, meta-analysis, polymorphism
format	article
author	Xu F Wang B Yao J
author_facet	Xu F Wang B Yao J
author_sort	Xu F
title	Association between the SLC6A4 gene and schizophrenia: an updated meta-analysis
title_short	Association between the SLC6A4 gene and schizophrenia: an updated meta-analysis
title_full	Association between the SLC6A4 gene and schizophrenia: an updated meta-analysis
title_fullStr	Association between the SLC6A4 gene and schizophrenia: an updated meta-analysis
title_full_unstemmed	Association between the SLC6A4 gene and schizophrenia: an updated meta-analysis
title_sort	association between the slc6a4 gene and schizophrenia: an updated meta-analysis
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/9b56b57bb99949e29182754a63692da3
work_keys_str_mv	AT xuf associationbetweentheslc6a4geneandschizophreniaanupdatedmetaanalysis AT wangb associationbetweentheslc6a4geneandschizophreniaanupdatedmetaanalysis AT yaoj associationbetweentheslc6a4geneandschizophreniaanupdatedmetaanalysis
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Association between the SLC6A4 gene and schizophrenia: an updated meta-analysis

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