Fatal Clostridium perfringens sepsis with spleen rupture and intraabdominal massive bleeding in a 37-week pregnancy

The maternal death rate remains unacceptably high worldwide, predominantly in areas of poor access to quality health services. According to the WHO, in 2017, 810 women died from preventable causes related to pregnancy and childbirth. Causes of maternal death are plenty, including previous morbidity...

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Autores principales:	Evariste Gafumbegete, Berend Jacob van der Weide, Stefanie Misgeld, Henning Schmidt, Alaa Eldin Elsharkawy
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Clostridium perfringens (CP) Sepsis Spleen rupture Intraabdominal massive bleeding Pregnancy Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/9b618ca020aa4e3b8ae54261068bb9c8
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spelling	oai:doaj.org-article:9b618ca020aa4e3b8ae54261068bb9c82021-12-02T05:01:36ZFatal Clostridium perfringens sepsis with spleen rupture and intraabdominal massive bleeding in a 37-week pregnancy2214-250910.1016/j.idcr.2021.e01355https://doaj.org/article/9b618ca020aa4e3b8ae54261068bb9c82021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2214250921003115https://doaj.org/toc/2214-2509The maternal death rate remains unacceptably high worldwide, predominantly in areas of poor access to quality health services. According to the WHO, in 2017, 810 women died from preventable causes related to pregnancy and childbirth. Causes of maternal death are plenty, including previous morbidity and unexpected causes. Among the latter are infectious disease-related deaths. Herein, we describe a case of a 29-year-old woman at 37 weeks’ gestation who presented with right upper quadrant pain, which was initially considered to be pregnancy-related. However, she collapsed shortly after the hospital admission. The physical examination revealed severe hypovolemic shock due to a large amount of intraperitoneal free fluid. The patient was immediately rushed into an emergency cesarean section followed by exploratory laparotomy, which demonstrated a large intra-abdominal hemorrhage. The patient and her fetus died in the operating room. An autopsy revealed acute gangrenous cholecystitis along with abundant rod-shaped bacteria within the mucosa and vessels of the gallbladder, gas gangrene and rupture of the spleen, and signs of shock.Clostridium perfringens (CP) was isolated in the culture of a splenic sample. Although CP is a well-known and dreadful infectious etiological agent, catastrophic cases still happen. The acquaintance of this infection by the caregivers is crucial for the early diagnosis and treatment. This is a quite unique way to provide a dismal chance of survival in sepsis cases by this agent.Evariste GafumbegeteBerend Jacob van der WeideStefanie MisgeldHenning SchmidtAlaa Eldin ElsharkawyElsevierarticleClostridium perfringens (CP)SepsisSpleen ruptureIntraabdominal massive bleedingPregnancyInfectious and parasitic diseasesRC109-216ENIDCases, Vol 26, Iss , Pp e01355- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Clostridium perfringens (CP) Sepsis Spleen rupture Intraabdominal massive bleeding Pregnancy Infectious and parasitic diseases RC109-216
spellingShingle	Clostridium perfringens (CP) Sepsis Spleen rupture Intraabdominal massive bleeding Pregnancy Infectious and parasitic diseases RC109-216 Evariste Gafumbegete Berend Jacob van der Weide Stefanie Misgeld Henning Schmidt Alaa Eldin Elsharkawy Fatal Clostridium perfringens sepsis with spleen rupture and intraabdominal massive bleeding in a 37-week pregnancy
description	The maternal death rate remains unacceptably high worldwide, predominantly in areas of poor access to quality health services. According to the WHO, in 2017, 810 women died from preventable causes related to pregnancy and childbirth. Causes of maternal death are plenty, including previous morbidity and unexpected causes. Among the latter are infectious disease-related deaths. Herein, we describe a case of a 29-year-old woman at 37 weeks’ gestation who presented with right upper quadrant pain, which was initially considered to be pregnancy-related. However, she collapsed shortly after the hospital admission. The physical examination revealed severe hypovolemic shock due to a large amount of intraperitoneal free fluid. The patient was immediately rushed into an emergency cesarean section followed by exploratory laparotomy, which demonstrated a large intra-abdominal hemorrhage. The patient and her fetus died in the operating room. An autopsy revealed acute gangrenous cholecystitis along with abundant rod-shaped bacteria within the mucosa and vessels of the gallbladder, gas gangrene and rupture of the spleen, and signs of shock.Clostridium perfringens (CP) was isolated in the culture of a splenic sample. Although CP is a well-known and dreadful infectious etiological agent, catastrophic cases still happen. The acquaintance of this infection by the caregivers is crucial for the early diagnosis and treatment. This is a quite unique way to provide a dismal chance of survival in sepsis cases by this agent.
format	article
author	Evariste Gafumbegete Berend Jacob van der Weide Stefanie Misgeld Henning Schmidt Alaa Eldin Elsharkawy
author_facet	Evariste Gafumbegete Berend Jacob van der Weide Stefanie Misgeld Henning Schmidt Alaa Eldin Elsharkawy
author_sort	Evariste Gafumbegete
title	Fatal Clostridium perfringens sepsis with spleen rupture and intraabdominal massive bleeding in a 37-week pregnancy
title_short	Fatal Clostridium perfringens sepsis with spleen rupture and intraabdominal massive bleeding in a 37-week pregnancy
title_full	Fatal Clostridium perfringens sepsis with spleen rupture and intraabdominal massive bleeding in a 37-week pregnancy
title_fullStr	Fatal Clostridium perfringens sepsis with spleen rupture and intraabdominal massive bleeding in a 37-week pregnancy
title_full_unstemmed	Fatal Clostridium perfringens sepsis with spleen rupture and intraabdominal massive bleeding in a 37-week pregnancy
title_sort	fatal clostridium perfringens sepsis with spleen rupture and intraabdominal massive bleeding in a 37-week pregnancy
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/9b618ca020aa4e3b8ae54261068bb9c8
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Fatal Clostridium perfringens sepsis with spleen rupture and intraabdominal massive bleeding in a 37-week pregnancy

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