An orifice shape-based reduced order model of patient-specific mitral valve regurgitation

Mitral valve regurgitation (MR) is one of the most prevalent valvular heart diseases. Its quantitative assessment is challenging but crucial for treatment decisions. Using computational fluid dynamics (CFD), we developed a reduced order model (ROM) describing the relationship between MR flow rates,...

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Autores principales:	J. Franz, K. Czechowicz, I. Waechter-Stehle, F. Hellmeier, F. Razafindrazaka, M. Kelm, J. Kempfert, A. Meyer, G. Archer, J. Weese, R. Hose, T. Kuehne, L. Goubergrits
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	mitral valve regurgitation pressure gradient computational fluid dynamics regurgitant orifice area 3d transesophageal echocardiography patient-specific model Engineering (General). Civil engineering (General) TA1-2040
Acceso en línea:	https://doaj.org/article/9b62d3f168bb4c6fac18fc0a0987c208
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spelling	oai:doaj.org-article:9b62d3f168bb4c6fac18fc0a0987c2082021-11-26T11:19:48ZAn orifice shape-based reduced order model of patient-specific mitral valve regurgitation1994-20601997-003X10.1080/19942060.2021.1995048https://doaj.org/article/9b62d3f168bb4c6fac18fc0a0987c2082021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/19942060.2021.1995048https://doaj.org/toc/1994-2060https://doaj.org/toc/1997-003XMitral valve regurgitation (MR) is one of the most prevalent valvular heart diseases. Its quantitative assessment is challenging but crucial for treatment decisions. Using computational fluid dynamics (CFD), we developed a reduced order model (ROM) describing the relationship between MR flow rates, transvalvular pressure differences, and the size and shape of the regurgitant valve orifice. Due to its low computational cost, this ROM could easily be implemented into clinical workflows to support the assessment of MR. We reconstructed mitral valves of 43 patients from 3D transesophageal echocardiographic images and estimated the 3D anatomic regurgitant orifice areas using a shrink-wrap algorithm. The orifice shapes were quantified with three dimensionless shape parameters. Steady-state CFD simulations in the reconstructed mitral valves were performed to analyse the relationship between the regurgitant orifice geometry and the regurgitant hemodynamics. Based on the results, three ROMs with increasing complexity were defined, all of which revealed very good agreement with CFD results with a mean bias below 3% for the MR flow rate. Classifying orifices into two shape groups and assigning group-specific flow coefficients in the ROM reduced the limit of agreement predicting regurgitant volumes from 9.0 ml to 5.7 ml at a mean regurgitant volume of 57 ml.J. FranzK. CzechowiczI. Waechter-StehleF. HellmeierF. RazafindrazakaM. KelmJ. KempfertA. MeyerG. ArcherJ. WeeseR. HoseT. KuehneL. GoubergritsTaylor & Francis Grouparticlemitral valve regurgitationpressure gradientcomputational fluid dynamicsregurgitant orifice area3d transesophageal echocardiographypatient-specific modelEngineering (General). Civil engineering (General)TA1-2040ENEngineering Applications of Computational Fluid Mechanics, Vol 15, Iss 1, Pp 1868-1884 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mitral valve regurgitation pressure gradient computational fluid dynamics regurgitant orifice area 3d transesophageal echocardiography patient-specific model Engineering (General). Civil engineering (General) TA1-2040
spellingShingle	mitral valve regurgitation pressure gradient computational fluid dynamics regurgitant orifice area 3d transesophageal echocardiography patient-specific model Engineering (General). Civil engineering (General) TA1-2040 J. Franz K. Czechowicz I. Waechter-Stehle F. Hellmeier F. Razafindrazaka M. Kelm J. Kempfert A. Meyer G. Archer J. Weese R. Hose T. Kuehne L. Goubergrits An orifice shape-based reduced order model of patient-specific mitral valve regurgitation
description	Mitral valve regurgitation (MR) is one of the most prevalent valvular heart diseases. Its quantitative assessment is challenging but crucial for treatment decisions. Using computational fluid dynamics (CFD), we developed a reduced order model (ROM) describing the relationship between MR flow rates, transvalvular pressure differences, and the size and shape of the regurgitant valve orifice. Due to its low computational cost, this ROM could easily be implemented into clinical workflows to support the assessment of MR. We reconstructed mitral valves of 43 patients from 3D transesophageal echocardiographic images and estimated the 3D anatomic regurgitant orifice areas using a shrink-wrap algorithm. The orifice shapes were quantified with three dimensionless shape parameters. Steady-state CFD simulations in the reconstructed mitral valves were performed to analyse the relationship between the regurgitant orifice geometry and the regurgitant hemodynamics. Based on the results, three ROMs with increasing complexity were defined, all of which revealed very good agreement with CFD results with a mean bias below 3% for the MR flow rate. Classifying orifices into two shape groups and assigning group-specific flow coefficients in the ROM reduced the limit of agreement predicting regurgitant volumes from 9.0 ml to 5.7 ml at a mean regurgitant volume of 57 ml.
format	article
author	J. Franz K. Czechowicz I. Waechter-Stehle F. Hellmeier F. Razafindrazaka M. Kelm J. Kempfert A. Meyer G. Archer J. Weese R. Hose T. Kuehne L. Goubergrits
author_facet	J. Franz K. Czechowicz I. Waechter-Stehle F. Hellmeier F. Razafindrazaka M. Kelm J. Kempfert A. Meyer G. Archer J. Weese R. Hose T. Kuehne L. Goubergrits
author_sort	J. Franz
title	An orifice shape-based reduced order model of patient-specific mitral valve regurgitation
title_short	An orifice shape-based reduced order model of patient-specific mitral valve regurgitation
title_full	An orifice shape-based reduced order model of patient-specific mitral valve regurgitation
title_fullStr	An orifice shape-based reduced order model of patient-specific mitral valve regurgitation
title_full_unstemmed	An orifice shape-based reduced order model of patient-specific mitral valve regurgitation
title_sort	orifice shape-based reduced order model of patient-specific mitral valve regurgitation
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/9b62d3f168bb4c6fac18fc0a0987c208
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An orifice shape-based reduced order model of patient-specific mitral valve regurgitation

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