One-pot aminobenzylation of aldehydes with toluenes

Amines are common targets in synthetic chemistry as they often display biological activity. Here, the authors report a one-pot aminobenzylation of aldehydes with readily available toluenes in presence of a sodium amide derivative and a cesium salt additive generating an array of valuable 1,2-diaryle...

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Autores principales: Zhiting Wang, Zhipeng Zheng, Xinyu Xu, Jianyou Mao, Patrick J. Walsh
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Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/9b6437b01ebf4f6ba01181e22c36f1fd
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spelling oai:doaj.org-article:9b6437b01ebf4f6ba01181e22c36f1fd2021-12-02T16:56:35ZOne-pot aminobenzylation of aldehydes with toluenes10.1038/s41467-018-05638-y2041-1723https://doaj.org/article/9b6437b01ebf4f6ba01181e22c36f1fd2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05638-yhttps://doaj.org/toc/2041-1723Amines are common targets in synthetic chemistry as they often display biological activity. Here, the authors report a one-pot aminobenzylation of aldehydes with readily available toluenes in presence of a sodium amide derivative and a cesium salt additive generating an array of valuable 1,2-diarylethylamine compounds.Zhiting WangZhipeng ZhengXinyu XuJianyou MaoPatrick J. WalshNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Zhiting Wang
Zhipeng Zheng
Xinyu Xu
Jianyou Mao
Patrick J. Walsh
One-pot aminobenzylation of aldehydes with toluenes
description Amines are common targets in synthetic chemistry as they often display biological activity. Here, the authors report a one-pot aminobenzylation of aldehydes with readily available toluenes in presence of a sodium amide derivative and a cesium salt additive generating an array of valuable 1,2-diarylethylamine compounds.
format article
author Zhiting Wang
Zhipeng Zheng
Xinyu Xu
Jianyou Mao
Patrick J. Walsh
author_facet Zhiting Wang
Zhipeng Zheng
Xinyu Xu
Jianyou Mao
Patrick J. Walsh
author_sort Zhiting Wang
title One-pot aminobenzylation of aldehydes with toluenes
title_short One-pot aminobenzylation of aldehydes with toluenes
title_full One-pot aminobenzylation of aldehydes with toluenes
title_fullStr One-pot aminobenzylation of aldehydes with toluenes
title_full_unstemmed One-pot aminobenzylation of aldehydes with toluenes
title_sort one-pot aminobenzylation of aldehydes with toluenes
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/9b6437b01ebf4f6ba01181e22c36f1fd
work_keys_str_mv AT zhitingwang onepotaminobenzylationofaldehydeswithtoluenes
AT zhipengzheng onepotaminobenzylationofaldehydeswithtoluenes
AT xinyuxu onepotaminobenzylationofaldehydeswithtoluenes
AT jianyoumao onepotaminobenzylationofaldehydeswithtoluenes
AT patrickjwalsh onepotaminobenzylationofaldehydeswithtoluenes
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