Efficacy of HIV antiviral polyanionic carbosilane dendrimer G2-S16 in the presence of semen

Rafael Ceña-Diez,1–4,* Pilar García-Broncano,1–5,* Francisco Javier de la Mata,4,6 Rafael Gómez,4,6 Mª Ángeles Muñoz-Fernández1–4 1Hospital General Universitario Gregorio Marañon, 2In...

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Autores principales:	Ceña-Diez R, García-Broncano P, de la Mata FJ, Gómez R, Muñoz-Fernández MA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	G2-S16 dendrimer HIV-1 SEVI microbicide antiretrovirals Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/9b65135def8d4e4f9c0d9a61cfc9003f
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spelling	oai:doaj.org-article:9b65135def8d4e4f9c0d9a61cfc9003f2021-12-02T05:09:55ZEfficacy of HIV antiviral polyanionic carbosilane dendrimer G2-S16 in the presence of semen1178-2013https://doaj.org/article/9b65135def8d4e4f9c0d9a61cfc9003f2016-05-01T00:00:00Zhttps://www.dovepress.com/efficacy-of-hiv-antiviral-polyanionic-carbosilane-dendrimer-g2-s16-in--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Rafael Ceña-Diez,1–4,* Pilar García-Broncano,1–5,* Francisco Javier de la Mata,4,6 Rafael Gómez,4,6 Mª Ángeles Muñoz-Fernández1–4 1Hospital General Universitario Gregorio Marañon, 2Instituto de Investigación Sanitaria Gregorio Marañon, 3Spanish HIV HGM Biobank, 4Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 5Laboratory of Viral Infection and Immunity, National Center of Microbiology, Health Institute of Carlos III, Majadahonda, 6Department of Organic Chemistry and Inorganic Chemistry, University of Alcalá, Alcalá de Henares, Madrid, Spain *These authors contributed equally to this work Abstract: The development of a safe and effective microbicide to prevent the sexual transmission of human immunodeficiency virus (HIV)-1 is urgently needed. Unfortunately, the majority of microbicides, such as poly(L-lysine)-dendrimers, anionic polymers, or antiretrovirals, have proved inactive or even increased the risk of HIV infection in clinical trials, most probably due to the fact that these compounds failed to prevent semen-exposed HIV infection. We showed that G2-S16 dendrimer exerts anti-HIV-1 activity at an early stage of viral replication, blocking the gp120/CD4/CCR5 interaction and providing a barrier to infection for long periods, confirming its multifactorial and nonspecific ability. Previously, we demonstrated that topical administration of G2-S16 prevents HIV transmission in humanized BLT mice without irritation or vaginal lesions. Here, we demonstrated that G2-S16 is active against mock- and semen-exposed HIV-1 and could be a promising microbicide against HIV infection. Keywords: G2-S16, dendrimer, HIV-1, SEVI, microbicide, antiretroviralsCeña-Diez RGarcía-Broncano Pde la Mata FJGómez RMuñoz-Fernández MADove Medical PressarticleG2-S16dendrimerHIV-1SEVImicrobicideantiretroviralsMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss default, Pp 2443-2450 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	G2-S16 dendrimer HIV-1 SEVI microbicide antiretrovirals Medicine (General) R5-920
spellingShingle	G2-S16 dendrimer HIV-1 SEVI microbicide antiretrovirals Medicine (General) R5-920 Ceña-Diez R García-Broncano P de la Mata FJ Gómez R Muñoz-Fernández MA Efficacy of HIV antiviral polyanionic carbosilane dendrimer G2-S16 in the presence of semen
description	Rafael Ceña-Diez,1–4,* Pilar García-Broncano,1–5,* Francisco Javier de la Mata,4,6 Rafael Gómez,4,6 Mª Ángeles Muñoz-Fernández1–4 1Hospital General Universitario Gregorio Marañon, 2Instituto de Investigación Sanitaria Gregorio Marañon, 3Spanish HIV HGM Biobank, 4Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 5Laboratory of Viral Infection and Immunity, National Center of Microbiology, Health Institute of Carlos III, Majadahonda, 6Department of Organic Chemistry and Inorganic Chemistry, University of Alcalá, Alcalá de Henares, Madrid, Spain *These authors contributed equally to this work Abstract: The development of a safe and effective microbicide to prevent the sexual transmission of human immunodeficiency virus (HIV)-1 is urgently needed. Unfortunately, the majority of microbicides, such as poly(L-lysine)-dendrimers, anionic polymers, or antiretrovirals, have proved inactive or even increased the risk of HIV infection in clinical trials, most probably due to the fact that these compounds failed to prevent semen-exposed HIV infection. We showed that G2-S16 dendrimer exerts anti-HIV-1 activity at an early stage of viral replication, blocking the gp120/CD4/CCR5 interaction and providing a barrier to infection for long periods, confirming its multifactorial and nonspecific ability. Previously, we demonstrated that topical administration of G2-S16 prevents HIV transmission in humanized BLT mice without irritation or vaginal lesions. Here, we demonstrated that G2-S16 is active against mock- and semen-exposed HIV-1 and could be a promising microbicide against HIV infection. Keywords: G2-S16, dendrimer, HIV-1, SEVI, microbicide, antiretrovirals
format	article
author	Ceña-Diez R García-Broncano P de la Mata FJ Gómez R Muñoz-Fernández MA
author_facet	Ceña-Diez R García-Broncano P de la Mata FJ Gómez R Muñoz-Fernández MA
author_sort	Ceña-Diez R
title	Efficacy of HIV antiviral polyanionic carbosilane dendrimer G2-S16 in the presence of semen
title_short	Efficacy of HIV antiviral polyanionic carbosilane dendrimer G2-S16 in the presence of semen
title_full	Efficacy of HIV antiviral polyanionic carbosilane dendrimer G2-S16 in the presence of semen
title_fullStr	Efficacy of HIV antiviral polyanionic carbosilane dendrimer G2-S16 in the presence of semen
title_full_unstemmed	Efficacy of HIV antiviral polyanionic carbosilane dendrimer G2-S16 in the presence of semen
title_sort	efficacy of hiv antiviral polyanionic carbosilane dendrimer g2-s16 in the presence of semen
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/9b65135def8d4e4f9c0d9a61cfc9003f
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Efficacy of HIV antiviral polyanionic carbosilane dendrimer G2-S16 in the presence of semen

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