A TNFRSF14-FcɛRI-mast cell pathway contributes to development of multiple features of asthma pathology in mice

A TNFRSF14-FcɛRI-mast cell pathway contributes to development of multiple features of asthma pathology in mice

TNFSF14 (LIGHT) contributes to airway inflammation and remodelling. Here the authors show that TNFSF14 acting on its receptor TNFRSF14 on mast cells enhances their IgE-dependent activation and that interference with this pathway attenuates features of asthma pathology in mice.

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Autores principales: Riccardo Sibilano, Nicolas Gaudenzio, Marianne K. DeGorter, Laurent L. Reber, Joseph D. Hernandez, Philipp M. Starkl, Oliwia W. Zurek, Mindy Tsai, Sonja Zahner, Stephen B. Montgomery, Axel Roers, Mitchell Kronenberg, Mang Yu, Stephen J. Galli
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Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/9b661fd658a64195915d136587d50be7
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spelling oai:doaj.org-article:9b661fd658a64195915d136587d50be72021-12-02T16:56:47ZA TNFRSF14-FcɛRI-mast cell pathway contributes to development of multiple features of asthma pathology in mice10.1038/ncomms136962041-1723https://doaj.org/article/9b661fd658a64195915d136587d50be72016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13696https://doaj.org/toc/2041-1723TNFSF14 (LIGHT) contributes to airway inflammation and remodelling. Here the authors show that TNFSF14 acting on its receptor TNFRSF14 on mast cells enhances their IgE-dependent activation and that interference with this pathway attenuates features of asthma pathology in mice.Riccardo SibilanoNicolas GaudenzioMarianne K. DeGorterLaurent L. ReberJoseph D. HernandezPhilipp M. StarklOliwia W. ZurekMindy TsaiSonja ZahnerStephen B. MontgomeryAxel RoersMitchell KronenbergMang YuStephen J. GalliNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Riccardo Sibilano
Nicolas Gaudenzio
Marianne K. DeGorter
Laurent L. Reber
Joseph D. Hernandez
Philipp M. Starkl
Oliwia W. Zurek
Mindy Tsai
Sonja Zahner
Stephen B. Montgomery
Axel Roers
Mitchell Kronenberg
Mang Yu
Stephen J. Galli
A TNFRSF14-FcɛRI-mast cell pathway contributes to development of multiple features of asthma pathology in mice
description TNFSF14 (LIGHT) contributes to airway inflammation and remodelling. Here the authors show that TNFSF14 acting on its receptor TNFRSF14 on mast cells enhances their IgE-dependent activation and that interference with this pathway attenuates features of asthma pathology in mice.
format article
author Riccardo Sibilano
Nicolas Gaudenzio
Marianne K. DeGorter
Laurent L. Reber
Joseph D. Hernandez
Philipp M. Starkl
Oliwia W. Zurek
Mindy Tsai
Sonja Zahner
Stephen B. Montgomery
Axel Roers
Mitchell Kronenberg
Mang Yu
Stephen J. Galli
author_facet Riccardo Sibilano
Nicolas Gaudenzio
Marianne K. DeGorter
Laurent L. Reber
Joseph D. Hernandez
Philipp M. Starkl
Oliwia W. Zurek
Mindy Tsai
Sonja Zahner
Stephen B. Montgomery
Axel Roers
Mitchell Kronenberg
Mang Yu
Stephen J. Galli
author_sort Riccardo Sibilano
title A TNFRSF14-FcɛRI-mast cell pathway contributes to development of multiple features of asthma pathology in mice
title_short A TNFRSF14-FcɛRI-mast cell pathway contributes to development of multiple features of asthma pathology in mice
title_full A TNFRSF14-FcɛRI-mast cell pathway contributes to development of multiple features of asthma pathology in mice
title_fullStr A TNFRSF14-FcɛRI-mast cell pathway contributes to development of multiple features of asthma pathology in mice
title_full_unstemmed A TNFRSF14-FcɛRI-mast cell pathway contributes to development of multiple features of asthma pathology in mice
title_sort tnfrsf14-fcɛri-mast cell pathway contributes to development of multiple features of asthma pathology in mice
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/9b661fd658a64195915d136587d50be7
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