Glycyrrhizin ameliorating sterile inflammation induced by low-dose radiation exposure

Abstract Glycyrrhizin (GL) is a direct inhibitor of HMGB1 which acts as an alarmin when excreted into the extracellular space. High-dose radiation in radiotherapy induces collateral damage to the normal tissue, which can be mitigated by GL inhibiting HMGB1. The purpose of this study was to assess ch...

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Autores principales:	Hyung Cheol Kim, Hyewon Oh, Je Sung You, Yong Eun Chung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9b67e99555b34b27afc2db72a82f5c5b
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spelling	oai:doaj.org-article:9b67e99555b34b27afc2db72a82f5c5b2021-12-02T15:15:40ZGlycyrrhizin ameliorating sterile inflammation induced by low-dose radiation exposure10.1038/s41598-021-97800-82045-2322https://doaj.org/article/9b67e99555b34b27afc2db72a82f5c5b2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97800-8https://doaj.org/toc/2045-2322Abstract Glycyrrhizin (GL) is a direct inhibitor of HMGB1 which acts as an alarmin when excreted into the extracellular space. High-dose radiation in radiotherapy induces collateral damage to the normal tissue, which can be mitigated by GL inhibiting HMGB1. The purpose of this study was to assess changes in HMGB1 and pro-inflammatory cytokines and to evaluate the protective effect of GL after low-dose radiation exposure. BALB/c mice were irradiated with 0.1 Gy (n = 10) and 1 Gy (n = 10) with GL being administered to half of the mice (n = 5, respectively) before irradiation. Blood and spleen samples were harvested and assessed for oxidative stress, HMGB1, pro-inflammatory cytokines, and cell viability. HMGB1 and pro-inflammatory cytokines increased and cell viability decreased after irradiation in a dose-dependent manner. Oxidative stress also increased after irradiation, but did not differ between 0.1 Gy and 1 Gy. With the pretreatment of GL, oxidative stress, HMGB1, and all of the pro-inflammatory cytokines decreased while cell viability was preserved. Our findings indicate that even low-dose radiation can induce sterile inflammation by increasing serum HMGB1 and pro-inflammatory cytokines and that GL can ameliorate the sterile inflammatory process by inhibiting HMGB1 to preserve cell viability.Hyung Cheol KimHyewon OhJe Sung YouYong Eun ChungNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hyung Cheol Kim Hyewon Oh Je Sung You Yong Eun Chung Glycyrrhizin ameliorating sterile inflammation induced by low-dose radiation exposure
description	Abstract Glycyrrhizin (GL) is a direct inhibitor of HMGB1 which acts as an alarmin when excreted into the extracellular space. High-dose radiation in radiotherapy induces collateral damage to the normal tissue, which can be mitigated by GL inhibiting HMGB1. The purpose of this study was to assess changes in HMGB1 and pro-inflammatory cytokines and to evaluate the protective effect of GL after low-dose radiation exposure. BALB/c mice were irradiated with 0.1 Gy (n = 10) and 1 Gy (n = 10) with GL being administered to half of the mice (n = 5, respectively) before irradiation. Blood and spleen samples were harvested and assessed for oxidative stress, HMGB1, pro-inflammatory cytokines, and cell viability. HMGB1 and pro-inflammatory cytokines increased and cell viability decreased after irradiation in a dose-dependent manner. Oxidative stress also increased after irradiation, but did not differ between 0.1 Gy and 1 Gy. With the pretreatment of GL, oxidative stress, HMGB1, and all of the pro-inflammatory cytokines decreased while cell viability was preserved. Our findings indicate that even low-dose radiation can induce sterile inflammation by increasing serum HMGB1 and pro-inflammatory cytokines and that GL can ameliorate the sterile inflammatory process by inhibiting HMGB1 to preserve cell viability.
format	article
author	Hyung Cheol Kim Hyewon Oh Je Sung You Yong Eun Chung
author_facet	Hyung Cheol Kim Hyewon Oh Je Sung You Yong Eun Chung
author_sort	Hyung Cheol Kim
title	Glycyrrhizin ameliorating sterile inflammation induced by low-dose radiation exposure
title_short	Glycyrrhizin ameliorating sterile inflammation induced by low-dose radiation exposure
title_full	Glycyrrhizin ameliorating sterile inflammation induced by low-dose radiation exposure
title_fullStr	Glycyrrhizin ameliorating sterile inflammation induced by low-dose radiation exposure
title_full_unstemmed	Glycyrrhizin ameliorating sterile inflammation induced by low-dose radiation exposure
title_sort	glycyrrhizin ameliorating sterile inflammation induced by low-dose radiation exposure
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9b67e99555b34b27afc2db72a82f5c5b
work_keys_str_mv	AT hyungcheolkim glycyrrhizinamelioratingsterileinflammationinducedbylowdoseradiationexposure AT hyewonoh glycyrrhizinamelioratingsterileinflammationinducedbylowdoseradiationexposure AT jesungyou glycyrrhizinamelioratingsterileinflammationinducedbylowdoseradiationexposure AT yongeunchung glycyrrhizinamelioratingsterileinflammationinducedbylowdoseradiationexposure
_version_	1718387523920592896

Glycyrrhizin ameliorating sterile inflammation induced by low-dose radiation exposure

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