Role of Ferroptosis in Non-Alcoholic Fatty Liver Disease and Its Implications for Therapeutic Strategies

Non-alcoholic fatty liver disease (NAFLD) has become the chronic liver disease with the highest incidence throughout the world, but its pathogenesis has not been fully elucidated. Ferroptosis is a novel form of programmed cell death caused by iron-dependent lipid peroxidation. Abnormal iron metaboli...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Han Zhang, Enxiang Zhang, Hongbo Hu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	ferroptosis NAFLD lipid peroxidation iron metabolism Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/9b691016568b458d8eb16abbcda01c30
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9b691016568b458d8eb16abbcda01c30
record_format	dspace
spelling	oai:doaj.org-article:9b691016568b458d8eb16abbcda01c302021-11-25T16:50:25ZRole of Ferroptosis in Non-Alcoholic Fatty Liver Disease and Its Implications for Therapeutic Strategies10.3390/biomedicines91116602227-9059https://doaj.org/article/9b691016568b458d8eb16abbcda01c302021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1660https://doaj.org/toc/2227-9059Non-alcoholic fatty liver disease (NAFLD) has become the chronic liver disease with the highest incidence throughout the world, but its pathogenesis has not been fully elucidated. Ferroptosis is a novel form of programmed cell death caused by iron-dependent lipid peroxidation. Abnormal iron metabolism, lipid peroxidation, and accumulation of polyunsaturated fatty acid phospholipids (PUFA-PLs) can all trigger ferroptosis. Emerging evidence indicates that ferroptosis plays a critical role in the pathological progression of NAFLD. Because the liver is the main organ for iron storage and lipid metabolism, ferroptosis is an ideal target for liver diseases. Inhibiting ferroptosis may become a new therapeutic strategy for the treatment of NAFLD. In this article, we describe the role of ferroptosis in the progression of NAFLD and its related mechanisms. This review will highlight further directions for the treatment of NAFLD and the selection of corresponding drugs that target ferroptosis.Han ZhangEnxiang ZhangHongbo HuMDPI AGarticleferroptosisNAFLDlipid peroxidationiron metabolismBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1660, p 1660 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ferroptosis NAFLD lipid peroxidation iron metabolism Biology (General) QH301-705.5
spellingShingle	ferroptosis NAFLD lipid peroxidation iron metabolism Biology (General) QH301-705.5 Han Zhang Enxiang Zhang Hongbo Hu Role of Ferroptosis in Non-Alcoholic Fatty Liver Disease and Its Implications for Therapeutic Strategies
description	Non-alcoholic fatty liver disease (NAFLD) has become the chronic liver disease with the highest incidence throughout the world, but its pathogenesis has not been fully elucidated. Ferroptosis is a novel form of programmed cell death caused by iron-dependent lipid peroxidation. Abnormal iron metabolism, lipid peroxidation, and accumulation of polyunsaturated fatty acid phospholipids (PUFA-PLs) can all trigger ferroptosis. Emerging evidence indicates that ferroptosis plays a critical role in the pathological progression of NAFLD. Because the liver is the main organ for iron storage and lipid metabolism, ferroptosis is an ideal target for liver diseases. Inhibiting ferroptosis may become a new therapeutic strategy for the treatment of NAFLD. In this article, we describe the role of ferroptosis in the progression of NAFLD and its related mechanisms. This review will highlight further directions for the treatment of NAFLD and the selection of corresponding drugs that target ferroptosis.
format	article
author	Han Zhang Enxiang Zhang Hongbo Hu
author_facet	Han Zhang Enxiang Zhang Hongbo Hu
author_sort	Han Zhang
title	Role of Ferroptosis in Non-Alcoholic Fatty Liver Disease and Its Implications for Therapeutic Strategies
title_short	Role of Ferroptosis in Non-Alcoholic Fatty Liver Disease and Its Implications for Therapeutic Strategies
title_full	Role of Ferroptosis in Non-Alcoholic Fatty Liver Disease and Its Implications for Therapeutic Strategies
title_fullStr	Role of Ferroptosis in Non-Alcoholic Fatty Liver Disease and Its Implications for Therapeutic Strategies
title_full_unstemmed	Role of Ferroptosis in Non-Alcoholic Fatty Liver Disease and Its Implications for Therapeutic Strategies
title_sort	role of ferroptosis in non-alcoholic fatty liver disease and its implications for therapeutic strategies
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/9b691016568b458d8eb16abbcda01c30
work_keys_str_mv	AT hanzhang roleofferroptosisinnonalcoholicfattyliverdiseaseanditsimplicationsfortherapeuticstrategies AT enxiangzhang roleofferroptosisinnonalcoholicfattyliverdiseaseanditsimplicationsfortherapeuticstrategies AT hongbohu roleofferroptosisinnonalcoholicfattyliverdiseaseanditsimplicationsfortherapeuticstrategies
_version_	1718412911504785408

Role of Ferroptosis in Non-Alcoholic Fatty Liver Disease and Its Implications for Therapeutic Strategies

Ejemplares similares