CYTOKINES IN ANTERIOR EYE CHAMBER LIQUID: THEIR ROLE IN DEVELOPMENT OF SYSTEMIC IMMUNE RESPONSE TO OCULAR TISSUE ANTIGENS

The work is dedicated to studies of interrelations between the cytokine contents in the liquid from anterior eye chamber (AEC), and development of systemic immune response to ocular tissue antigens, described in terms of an anterior eye chamber-associated immune disturbance (ACAID phenomenon). The i...

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Autores principales:	I. G. Kulikova, O. S. Slepova, E. V. Denisova, L. A. Kovaleva, P. V. Makarov, D. N. Lovpache
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2015
Materias:	cytokines anterior eye chamber organ-specific autoimmunity multiplex analysis migration inhibition test leukocytes ophthalmopathology Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/9b6990712bd64dd09f3e406c0e116849
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spelling	oai:doaj.org-article:9b6990712bd64dd09f3e406c0e1168492021-11-18T08:03:44ZCYTOKINES IN ANTERIOR EYE CHAMBER LIQUID: THEIR ROLE IN DEVELOPMENT OF SYSTEMIC IMMUNE RESPONSE TO OCULAR TISSUE ANTIGENS1563-06252313-741X10.15789/1563-0625-2015-2-179-182https://doaj.org/article/9b6990712bd64dd09f3e406c0e1168492015-04-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/837https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe work is dedicated to studies of interrelations between the cytokine contents in the liquid from anterior eye chamber (AEC), and development of systemic immune response to ocular tissue antigens, described in terms of an anterior eye chamber-associated immune disturbance (ACAID phenomenon). The immune assays were conducted in parallel, using multiplex cytokine analysis (flow cytometry technique), and leukocyte inhibition migration reaction. Twenty-six patients with different forms of ophthalmic pathology were examined, including cases of uveitis (18), keratouveitis (3), glaucoma (5). It is shown that the reduced TGF-β1 levels and increased concentrations of proinflammatory, chemotactic cytokines in AEC liquid are associated with development of organ-specific immune sensitization.I. G. KulikovaO. S. SlepovaE. V. DenisovaL. A. KovalevaP. V. MakarovD. N. LovpacheSPb RAACIarticlecytokinesanterior eye chamberorgan-specific autoimmunitymultiplex analysismigration inhibition testleukocytesophthalmopathologyImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 17, Iss 2, Pp 179-182 (2015)
institution	DOAJ
collection	DOAJ
language	RU
topic	cytokines anterior eye chamber organ-specific autoimmunity multiplex analysis migration inhibition test leukocytes ophthalmopathology Immunologic diseases. Allergy RC581-607
spellingShingle	cytokines anterior eye chamber organ-specific autoimmunity multiplex analysis migration inhibition test leukocytes ophthalmopathology Immunologic diseases. Allergy RC581-607 I. G. Kulikova O. S. Slepova E. V. Denisova L. A. Kovaleva P. V. Makarov D. N. Lovpache CYTOKINES IN ANTERIOR EYE CHAMBER LIQUID: THEIR ROLE IN DEVELOPMENT OF SYSTEMIC IMMUNE RESPONSE TO OCULAR TISSUE ANTIGENS
description	The work is dedicated to studies of interrelations between the cytokine contents in the liquid from anterior eye chamber (AEC), and development of systemic immune response to ocular tissue antigens, described in terms of an anterior eye chamber-associated immune disturbance (ACAID phenomenon). The immune assays were conducted in parallel, using multiplex cytokine analysis (flow cytometry technique), and leukocyte inhibition migration reaction. Twenty-six patients with different forms of ophthalmic pathology were examined, including cases of uveitis (18), keratouveitis (3), glaucoma (5). It is shown that the reduced TGF-β1 levels and increased concentrations of proinflammatory, chemotactic cytokines in AEC liquid are associated with development of organ-specific immune sensitization.
format	article
author	I. G. Kulikova O. S. Slepova E. V. Denisova L. A. Kovaleva P. V. Makarov D. N. Lovpache
author_facet	I. G. Kulikova O. S. Slepova E. V. Denisova L. A. Kovaleva P. V. Makarov D. N. Lovpache
author_sort	I. G. Kulikova
title	CYTOKINES IN ANTERIOR EYE CHAMBER LIQUID: THEIR ROLE IN DEVELOPMENT OF SYSTEMIC IMMUNE RESPONSE TO OCULAR TISSUE ANTIGENS
title_short	CYTOKINES IN ANTERIOR EYE CHAMBER LIQUID: THEIR ROLE IN DEVELOPMENT OF SYSTEMIC IMMUNE RESPONSE TO OCULAR TISSUE ANTIGENS
title_full	CYTOKINES IN ANTERIOR EYE CHAMBER LIQUID: THEIR ROLE IN DEVELOPMENT OF SYSTEMIC IMMUNE RESPONSE TO OCULAR TISSUE ANTIGENS
title_fullStr	CYTOKINES IN ANTERIOR EYE CHAMBER LIQUID: THEIR ROLE IN DEVELOPMENT OF SYSTEMIC IMMUNE RESPONSE TO OCULAR TISSUE ANTIGENS
title_full_unstemmed	CYTOKINES IN ANTERIOR EYE CHAMBER LIQUID: THEIR ROLE IN DEVELOPMENT OF SYSTEMIC IMMUNE RESPONSE TO OCULAR TISSUE ANTIGENS
title_sort	cytokines in anterior eye chamber liquid: their role in development of systemic immune response to ocular tissue antigens
publisher	SPb RAACI
publishDate	2015
url	https://doaj.org/article/9b6990712bd64dd09f3e406c0e116849
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CYTOKINES IN ANTERIOR EYE CHAMBER LIQUID: THEIR ROLE IN DEVELOPMENT OF SYSTEMIC IMMUNE RESPONSE TO OCULAR TISSUE ANTIGENS

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