A very high infection intensity of Schistosoma mansoni in a Ugandan Lake Victoria Fishing Community is required for association with highly prevalent organ related morbidity.

<h4>Background</h4>In schistosomiasis control programmes using mass chemotherapy, epidemiological and morbidity aspects of the disease need to be studied so as to monitor the impact of treatment, and make recommendations accordingly. These aspects were examined in the community of Musoli...

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Autores principales:	Edridah M Tukahebwa, Pascal Magnussen, Henry Madsen, Narcis B Kabatereine, Fred Nuwaha, Shona Wilson, Birgitte J Vennervald
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/9b6e9bec1ea4447c8656f466dd9563a0
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spelling	oai:doaj.org-article:9b6e9bec1ea4447c8656f466dd9563a02021-11-18T09:17:06ZA very high infection intensity of Schistosoma mansoni in a Ugandan Lake Victoria Fishing Community is required for association with highly prevalent organ related morbidity.1935-27271935-273510.1371/journal.pntd.0002268https://doaj.org/article/9b6e9bec1ea4447c8656f466dd9563a02013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23936559/?tool=EBIhttps://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735<h4>Background</h4>In schistosomiasis control programmes using mass chemotherapy, epidemiological and morbidity aspects of the disease need to be studied so as to monitor the impact of treatment, and make recommendations accordingly. These aspects were examined in the community of Musoli village along Lake Victoria in Mayuge district, highly endemic for Schistosoma mansoni infection.<h4>Methodology and principal findings</h4>A cross sectional descriptive study was undertaken in a randomly selected sample of 217 females and 229 males, with a mean age of 26 years (SD ± 16, range 7-76 years). The prevalence of S. mansoni was 88.6% (95% CI: 85.6-91.5). The geometric mean intensity (GMI) of S. mansoni was 236.2 (95% CI: 198.5-460.9) eggs per gram (epg) faeces. Males had significantly higher GMI (370.2 epg) than females (132.6 epg) and age was also significantly associated with intensity of infection. Levels of water contact activities significantly influenced intensity of infection and the highest intensity of infection was found among people involved in fishing. However, organomegaly was not significantly associated with S. mansoni except for very heavy infection (>2000 epg). Liver image patterns C and D indicative of fibrosis were found in only 2.2% and 0.2%, respectively. S. mansoni intensity of infection was associated with portal vein dilation and abnormal spleen length. Anaemia was observed in 36.4% of the participants but it was not associated with S. mansoni infection intensity. Considering growth in children as one of the morbidity indicators of schistosomiasis, intensity of S. mansoni was significantly associated with stunting.<h4>Conclusion</h4>Although organ-related morbidity, with the exception of periportal fibrosis, and S. mansoni infections were highly prevalent, the two were only associated for individuals with very high infection intensities. These results contrast starkly with reports from Ugandan Lake Albert fishing communities in which periportal fibrosis is more prevalent.Edridah M TukahebwaPascal MagnussenHenry MadsenNarcis B KabatereineFred NuwahaShona WilsonBirgitte J VennervaldPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 7, Iss 7, p e2268 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Edridah M Tukahebwa Pascal Magnussen Henry Madsen Narcis B Kabatereine Fred Nuwaha Shona Wilson Birgitte J Vennervald A very high infection intensity of Schistosoma mansoni in a Ugandan Lake Victoria Fishing Community is required for association with highly prevalent organ related morbidity.
description	<h4>Background</h4>In schistosomiasis control programmes using mass chemotherapy, epidemiological and morbidity aspects of the disease need to be studied so as to monitor the impact of treatment, and make recommendations accordingly. These aspects were examined in the community of Musoli village along Lake Victoria in Mayuge district, highly endemic for Schistosoma mansoni infection.<h4>Methodology and principal findings</h4>A cross sectional descriptive study was undertaken in a randomly selected sample of 217 females and 229 males, with a mean age of 26 years (SD ± 16, range 7-76 years). The prevalence of S. mansoni was 88.6% (95% CI: 85.6-91.5). The geometric mean intensity (GMI) of S. mansoni was 236.2 (95% CI: 198.5-460.9) eggs per gram (epg) faeces. Males had significantly higher GMI (370.2 epg) than females (132.6 epg) and age was also significantly associated with intensity of infection. Levels of water contact activities significantly influenced intensity of infection and the highest intensity of infection was found among people involved in fishing. However, organomegaly was not significantly associated with S. mansoni except for very heavy infection (>2000 epg). Liver image patterns C and D indicative of fibrosis were found in only 2.2% and 0.2%, respectively. S. mansoni intensity of infection was associated with portal vein dilation and abnormal spleen length. Anaemia was observed in 36.4% of the participants but it was not associated with S. mansoni infection intensity. Considering growth in children as one of the morbidity indicators of schistosomiasis, intensity of S. mansoni was significantly associated with stunting.<h4>Conclusion</h4>Although organ-related morbidity, with the exception of periportal fibrosis, and S. mansoni infections were highly prevalent, the two were only associated for individuals with very high infection intensities. These results contrast starkly with reports from Ugandan Lake Albert fishing communities in which periportal fibrosis is more prevalent.
format	article
author	Edridah M Tukahebwa Pascal Magnussen Henry Madsen Narcis B Kabatereine Fred Nuwaha Shona Wilson Birgitte J Vennervald
author_facet	Edridah M Tukahebwa Pascal Magnussen Henry Madsen Narcis B Kabatereine Fred Nuwaha Shona Wilson Birgitte J Vennervald
author_sort	Edridah M Tukahebwa
title	A very high infection intensity of Schistosoma mansoni in a Ugandan Lake Victoria Fishing Community is required for association with highly prevalent organ related morbidity.
title_short	A very high infection intensity of Schistosoma mansoni in a Ugandan Lake Victoria Fishing Community is required for association with highly prevalent organ related morbidity.
title_full	A very high infection intensity of Schistosoma mansoni in a Ugandan Lake Victoria Fishing Community is required for association with highly prevalent organ related morbidity.
title_fullStr	A very high infection intensity of Schistosoma mansoni in a Ugandan Lake Victoria Fishing Community is required for association with highly prevalent organ related morbidity.
title_full_unstemmed	A very high infection intensity of Schistosoma mansoni in a Ugandan Lake Victoria Fishing Community is required for association with highly prevalent organ related morbidity.
title_sort	very high infection intensity of schistosoma mansoni in a ugandan lake victoria fishing community is required for association with highly prevalent organ related morbidity.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/9b6e9bec1ea4447c8656f466dd9563a0
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A very high infection intensity of Schistosoma mansoni in a Ugandan Lake Victoria Fishing Community is required for association with highly prevalent organ related morbidity.

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