Submucosal and muscular layers for Ganglion cells in diagnosis of Hirschsprungs disease (H.D): A comparative study

Background and Objective: Hirschsprung’s disease (H.D) is the most common cause of lower gastrointestinal tract obstruction in newborns. Diagnosis of H.D was established by a full-thickness rectal biopsy, then it was replaced by rectal suction biopsy, that is easier and has less complications. This...

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Autores principales:	E Shafigh, S Siadati, S Mohammad Bagherzadeh Torbati, RA Rezaiyan, K Hajian
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2004
Materias:	hirschsprungs disease full-thickness biopsy ganglion cell rectal suction biopsy Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/9b725de317df45f6b480096a1c183397
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spelling	oai:doaj.org-article:9b725de317df45f6b480096a1c1833972021-11-10T09:16:12ZSubmucosal and muscular layers for Ganglion cells in diagnosis of Hirschsprungs disease (H.D): A comparative study1561-41072251-7170https://doaj.org/article/9b725de317df45f6b480096a1c1833972004-07-01T00:00:00Zhttp://jbums.org/article-1-2688-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170Background and Objective: Hirschsprung’s disease (H.D) is the most common cause of lower gastrointestinal tract obstruction in newborns. Diagnosis of H.D was established by a full-thickness rectal biopsy, then it was replaced by rectal suction biopsy, that is easier and has less complications. This study was done to compare the submucosal and muscular coat of rectal wall for ganglion cells. Methods: In this descriptive, analytical and cross-sectional study, data were obtained from 239 pathological reports in archive of Shahid Beheshti hospital, department of pathology from 1991 to 2001. Serial sections (Up to 60 sections) were tested microscopically. Findings: Sixty-one from 239 specimens were diagnosed as H.D (19.3%) and in 172 cases ganglion cells were present in both muscular and submucosal layers (54.43%). Sensitivity of submucosal for presence of ganglion cells was 96.6% and correlation between submucosal and muscular layers for absence of ganglion cell was 100% (P<0.05). Conclusion: The results showed a good correlation between advantages of serial sections of muscular and submucosal layers for presence of ganglion cells. Probability of coincident presence of ganglion cells in both layers was confirmed.E ShafighS SiadatiS Mohammad Bagherzadeh TorbatiRA RezaiyanK HajianBabol University of Medical Sciencesarticlehirschsprungs diseasefull-thickness biopsyganglion cellrectal suction biopsyMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 6, Iss 3, Pp 26-31 (2004)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	hirschsprungs disease full-thickness biopsy ganglion cell rectal suction biopsy Medicine R Medicine (General) R5-920
spellingShingle	hirschsprungs disease full-thickness biopsy ganglion cell rectal suction biopsy Medicine R Medicine (General) R5-920 E Shafigh S Siadati S Mohammad Bagherzadeh Torbati RA Rezaiyan K Hajian Submucosal and muscular layers for Ganglion cells in diagnosis of Hirschsprungs disease (H.D): A comparative study
description	Background and Objective: Hirschsprung’s disease (H.D) is the most common cause of lower gastrointestinal tract obstruction in newborns. Diagnosis of H.D was established by a full-thickness rectal biopsy, then it was replaced by rectal suction biopsy, that is easier and has less complications. This study was done to compare the submucosal and muscular coat of rectal wall for ganglion cells. Methods: In this descriptive, analytical and cross-sectional study, data were obtained from 239 pathological reports in archive of Shahid Beheshti hospital, department of pathology from 1991 to 2001. Serial sections (Up to 60 sections) were tested microscopically. Findings: Sixty-one from 239 specimens were diagnosed as H.D (19.3%) and in 172 cases ganglion cells were present in both muscular and submucosal layers (54.43%). Sensitivity of submucosal for presence of ganglion cells was 96.6% and correlation between submucosal and muscular layers for absence of ganglion cell was 100% (P<0.05). Conclusion: The results showed a good correlation between advantages of serial sections of muscular and submucosal layers for presence of ganglion cells. Probability of coincident presence of ganglion cells in both layers was confirmed.
format	article
author	E Shafigh S Siadati S Mohammad Bagherzadeh Torbati RA Rezaiyan K Hajian
author_facet	E Shafigh S Siadati S Mohammad Bagherzadeh Torbati RA Rezaiyan K Hajian
author_sort	E Shafigh
title	Submucosal and muscular layers for Ganglion cells in diagnosis of Hirschsprungs disease (H.D): A comparative study
title_short	Submucosal and muscular layers for Ganglion cells in diagnosis of Hirschsprungs disease (H.D): A comparative study
title_full	Submucosal and muscular layers for Ganglion cells in diagnosis of Hirschsprungs disease (H.D): A comparative study
title_fullStr	Submucosal and muscular layers for Ganglion cells in diagnosis of Hirschsprungs disease (H.D): A comparative study
title_full_unstemmed	Submucosal and muscular layers for Ganglion cells in diagnosis of Hirschsprungs disease (H.D): A comparative study
title_sort	submucosal and muscular layers for ganglion cells in diagnosis of hirschsprungs disease (h.d): a comparative study
publisher	Babol University of Medical Sciences
publishDate	2004
url	https://doaj.org/article/9b725de317df45f6b480096a1c183397
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Submucosal and muscular layers for Ganglion cells in diagnosis of Hirschsprungs disease (H.D): A comparative study

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