Mathematical modeling of impact of eCD4-Ig molecule in control and management of HIV within a host

Eradication and eventually cure of the HIV virus from the infected individual should be the primary goal in all HIV therapy. This has yet to be achieved, however development of broadly neutralizing antibodies (bNabs) and eCD4-Ig and its related particles are promising therapeutic alternatives to eli...

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Autores principales:	Tae Jin Lee, Jose A. Vazquez, Arni S. R. Srinivasa Rao
Formato:	article
Lenguaje:	EN
Publicado:	AIMS Press 2021
Materias:	hiv ecd4-ig ode model antibody Biotechnology TP248.13-248.65 Mathematics QA1-939
Acceso en línea:	https://doaj.org/article/9b73cc7a2692414fba9c20d73d8bc05c
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spelling	oai:doaj.org-article:9b73cc7a2692414fba9c20d73d8bc05c2021-11-23T01:16:39ZMathematical modeling of impact of eCD4-Ig molecule in control and management of HIV within a host10.3934/mbe.20213421551-0018https://doaj.org/article/9b73cc7a2692414fba9c20d73d8bc05c2021-08-01T00:00:00Zhttps://www.aimspress.com/article/doi/10.3934/mbe.2021342?viewType=HTMLhttps://doaj.org/toc/1551-0018Eradication and eventually cure of the HIV virus from the infected individual should be the primary goal in all HIV therapy. This has yet to be achieved, however development of broadly neutralizing antibodies (bNabs) and eCD4-Ig and its related particles are promising therapeutic alternatives to eliminate the HIV virus from the host. Past studies have found superior protectivity and efficacy eradicating the HIV virus with the use of eCD4-Igs over bNabs, which has proposed the antibody-dependent cell-mediated cytotoxicity (ADCC) effect as one of the key-factors for antibody design. In this study, we evaluated the dynamics of the HIV virus, CD4 T-cells, and eCD4-Ig in humans using a gene-therapy approach which has been evaluated in primates previously. We utilized a mathematical model to investigate the relationship between eCD4-Ig levels, ADCC effects, and the neutralization effect on HIV elimination. In addition, a balance between ADCC and viral neutralization effect of eCD4-Ig has been investigated in order to understand the condition of which HIV eliminating antibodies needs to satisfy. Our analysis indicated some level of ADCC effect, which was missing from ART, was required for viral elimination. The results will be helpful in designing future drugs or therapeutic strategies.Tae Jin LeeJose A. VazquezArni S. R. Srinivasa RaoAIMS Pressarticlehivecd4-igode modelantibodyBiotechnologyTP248.13-248.65MathematicsQA1-939ENMathematical Biosciences and Engineering, Vol 18, Iss 5, Pp 6887-6906 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hiv ecd4-ig ode model antibody Biotechnology TP248.13-248.65 Mathematics QA1-939
spellingShingle	hiv ecd4-ig ode model antibody Biotechnology TP248.13-248.65 Mathematics QA1-939 Tae Jin Lee Jose A. Vazquez Arni S. R. Srinivasa Rao Mathematical modeling of impact of eCD4-Ig molecule in control and management of HIV within a host
description	Eradication and eventually cure of the HIV virus from the infected individual should be the primary goal in all HIV therapy. This has yet to be achieved, however development of broadly neutralizing antibodies (bNabs) and eCD4-Ig and its related particles are promising therapeutic alternatives to eliminate the HIV virus from the host. Past studies have found superior protectivity and efficacy eradicating the HIV virus with the use of eCD4-Igs over bNabs, which has proposed the antibody-dependent cell-mediated cytotoxicity (ADCC) effect as one of the key-factors for antibody design. In this study, we evaluated the dynamics of the HIV virus, CD4 T-cells, and eCD4-Ig in humans using a gene-therapy approach which has been evaluated in primates previously. We utilized a mathematical model to investigate the relationship between eCD4-Ig levels, ADCC effects, and the neutralization effect on HIV elimination. In addition, a balance between ADCC and viral neutralization effect of eCD4-Ig has been investigated in order to understand the condition of which HIV eliminating antibodies needs to satisfy. Our analysis indicated some level of ADCC effect, which was missing from ART, was required for viral elimination. The results will be helpful in designing future drugs or therapeutic strategies.
format	article
author	Tae Jin Lee Jose A. Vazquez Arni S. R. Srinivasa Rao
author_facet	Tae Jin Lee Jose A. Vazquez Arni S. R. Srinivasa Rao
author_sort	Tae Jin Lee
title	Mathematical modeling of impact of eCD4-Ig molecule in control and management of HIV within a host
title_short	Mathematical modeling of impact of eCD4-Ig molecule in control and management of HIV within a host
title_full	Mathematical modeling of impact of eCD4-Ig molecule in control and management of HIV within a host
title_fullStr	Mathematical modeling of impact of eCD4-Ig molecule in control and management of HIV within a host
title_full_unstemmed	Mathematical modeling of impact of eCD4-Ig molecule in control and management of HIV within a host
title_sort	mathematical modeling of impact of ecd4-ig molecule in control and management of hiv within a host
publisher	AIMS Press
publishDate	2021
url	https://doaj.org/article/9b73cc7a2692414fba9c20d73d8bc05c
work_keys_str_mv	AT taejinlee mathematicalmodelingofimpactofecd4igmoleculeincontrolandmanagementofhivwithinahost AT joseavazquez mathematicalmodelingofimpactofecd4igmoleculeincontrolandmanagementofhivwithinahost AT arnisrsrinivasarao mathematicalmodelingofimpactofecd4igmoleculeincontrolandmanagementofhivwithinahost
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Mathematical modeling of impact of eCD4-Ig molecule in control and management of HIV within a host

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