CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage
Gene editing strategies are typically designed to correct mutant genes, but most neurodegenerative diseases are sporadic. Here the authors describe a strategy to selectively edit the C-terminus of APP and attenuate amyloid-β production, while upregulating neuroprotective α-cleavage.
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Nature Portfolio
2019
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oai:doaj.org-article:9b7514e64c5f429f8af27f9559663d3c2021-12-02T14:38:59ZCRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage10.1038/s41467-018-07971-82041-1723https://doaj.org/article/9b7514e64c5f429f8af27f9559663d3c2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07971-8https://doaj.org/toc/2041-1723Gene editing strategies are typically designed to correct mutant genes, but most neurodegenerative diseases are sporadic. Here the authors describe a strategy to selectively edit the C-terminus of APP and attenuate amyloid-β production, while upregulating neuroprotective α-cleavage.Jichao SunJared Carlson-StevermerUtpal DasMinjie ShenMarion DelenclosAmanda M. SneadSo Yeon KooLina WangDianhua QiaoJonathan LoiAndrew J. PetersenMichael StocktonAnita BhattacharyyaMathew V. JonesXinyu ZhaoPamela J. McLeanAndrew A. SproulKrishanu SahaSubhojit RoyNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Jichao Sun Jared Carlson-Stevermer Utpal Das Minjie Shen Marion Delenclos Amanda M. Snead So Yeon Koo Lina Wang Dianhua Qiao Jonathan Loi Andrew J. Petersen Michael Stockton Anita Bhattacharyya Mathew V. Jones Xinyu Zhao Pamela J. McLean Andrew A. Sproul Krishanu Saha Subhojit Roy CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage |
| description |
Gene editing strategies are typically designed to correct mutant genes, but most neurodegenerative diseases are sporadic. Here the authors describe a strategy to selectively edit the C-terminus of APP and attenuate amyloid-β production, while upregulating neuroprotective α-cleavage. |
| format |
article |
| author |
Jichao Sun Jared Carlson-Stevermer Utpal Das Minjie Shen Marion Delenclos Amanda M. Snead So Yeon Koo Lina Wang Dianhua Qiao Jonathan Loi Andrew J. Petersen Michael Stockton Anita Bhattacharyya Mathew V. Jones Xinyu Zhao Pamela J. McLean Andrew A. Sproul Krishanu Saha Subhojit Roy |
| author_facet |
Jichao Sun Jared Carlson-Stevermer Utpal Das Minjie Shen Marion Delenclos Amanda M. Snead So Yeon Koo Lina Wang Dianhua Qiao Jonathan Loi Andrew J. Petersen Michael Stockton Anita Bhattacharyya Mathew V. Jones Xinyu Zhao Pamela J. McLean Andrew A. Sproul Krishanu Saha Subhojit Roy |
| author_sort |
Jichao Sun |
| title |
CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage |
| title_short |
CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage |
| title_full |
CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage |
| title_fullStr |
CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage |
| title_full_unstemmed |
CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage |
| title_sort |
crispr/cas9 editing of app c-terminus attenuates β-cleavage and promotes α-cleavage |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/9b7514e64c5f429f8af27f9559663d3c |
| work_keys_str_mv |
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| _version_ |
1718390786403336192 |