Hormonal Characteristics of Women Receiving Ovarian Tissue Transplantation with or without Endogenous Ovarian Activity

Ovarian tissue cryopreservation (OTC) and transplantation of frozen/thawed ovarian tissue (OTT) are used for fertility preservation in girls and women. Here, we evaluated the hormonal characteristics of women with or without postmenopausal levels of FSH at the time of OTT to study differences and co...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Vinnie Hornshøj Greve, Margit Dueholm, Linn Salto Mamsen, Stine Gry Kristensen, Erik Ernst, Claus-Yding Andersen
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	transplantation of ovarian tissue FSH AMH regaining ovarian activity age Medicine R
Acceso en línea:	https://doaj.org/article/9b751f35c5d3466a8a4d03c4e974c942
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9b751f35c5d3466a8a4d03c4e974c942
record_format	dspace
spelling	oai:doaj.org-article:9b751f35c5d3466a8a4d03c4e974c9422021-11-25T18:00:33ZHormonal Characteristics of Women Receiving Ovarian Tissue Transplantation with or without Endogenous Ovarian Activity10.3390/jcm102252172077-0383https://doaj.org/article/9b751f35c5d3466a8a4d03c4e974c9422021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5217https://doaj.org/toc/2077-0383Ovarian tissue cryopreservation (OTC) and transplantation of frozen/thawed ovarian tissue (OTT) are used for fertility preservation in girls and women. Here, we evaluated the hormonal characteristics of women with or without postmenopausal levels of FSH at the time of OTT to study differences and conditions that best support the initiation of ovarian function. A total of 74 women undergoing OTT (<i>n</i> = 51 with menopausal levels of FSH; <i>n</i> = 23 with premenopausal levels) were followed by measurements of FSH, LH, AMH, and oestradiol. Concentrations of FSH and LH returned to premenopausal levels after 20 weeks on average, with a concomitant increase in oestradiol. Despite resumption of ovarian activity, AMH concentrations were in most instances below the detection limit in the menopausal group, suggesting a low ovarian reserve. Despite a higher age in the premenopausal group, they more often experienced an AMH increase than the menopausal group, suggesting that conditions in the premenopausal ovary better sustain follicle survival, perhaps due to the higher concentrations of oestradiol. Collectively, this study highlights the need for improving follicle survival after OTT. Age and the amount of tissue transplanted are important factors that influence the ability to regain ovarian activity and levels of FSH may need to be downregulated and oestradiol increased prior to OTT.Vinnie Hornshøj GreveMargit DueholmLinn Salto MamsenStine Gry KristensenErik ErnstClaus-Yding AndersenMDPI AGarticletransplantation of ovarian tissueFSHAMHregaining ovarian activityageMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5217, p 5217 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	transplantation of ovarian tissue FSH AMH regaining ovarian activity age Medicine R
spellingShingle	transplantation of ovarian tissue FSH AMH regaining ovarian activity age Medicine R Vinnie Hornshøj Greve Margit Dueholm Linn Salto Mamsen Stine Gry Kristensen Erik Ernst Claus-Yding Andersen Hormonal Characteristics of Women Receiving Ovarian Tissue Transplantation with or without Endogenous Ovarian Activity
description	Ovarian tissue cryopreservation (OTC) and transplantation of frozen/thawed ovarian tissue (OTT) are used for fertility preservation in girls and women. Here, we evaluated the hormonal characteristics of women with or without postmenopausal levels of FSH at the time of OTT to study differences and conditions that best support the initiation of ovarian function. A total of 74 women undergoing OTT (<i>n</i> = 51 with menopausal levels of FSH; <i>n</i> = 23 with premenopausal levels) were followed by measurements of FSH, LH, AMH, and oestradiol. Concentrations of FSH and LH returned to premenopausal levels after 20 weeks on average, with a concomitant increase in oestradiol. Despite resumption of ovarian activity, AMH concentrations were in most instances below the detection limit in the menopausal group, suggesting a low ovarian reserve. Despite a higher age in the premenopausal group, they more often experienced an AMH increase than the menopausal group, suggesting that conditions in the premenopausal ovary better sustain follicle survival, perhaps due to the higher concentrations of oestradiol. Collectively, this study highlights the need for improving follicle survival after OTT. Age and the amount of tissue transplanted are important factors that influence the ability to regain ovarian activity and levels of FSH may need to be downregulated and oestradiol increased prior to OTT.
format	article
author	Vinnie Hornshøj Greve Margit Dueholm Linn Salto Mamsen Stine Gry Kristensen Erik Ernst Claus-Yding Andersen
author_facet	Vinnie Hornshøj Greve Margit Dueholm Linn Salto Mamsen Stine Gry Kristensen Erik Ernst Claus-Yding Andersen
author_sort	Vinnie Hornshøj Greve
title	Hormonal Characteristics of Women Receiving Ovarian Tissue Transplantation with or without Endogenous Ovarian Activity
title_short	Hormonal Characteristics of Women Receiving Ovarian Tissue Transplantation with or without Endogenous Ovarian Activity
title_full	Hormonal Characteristics of Women Receiving Ovarian Tissue Transplantation with or without Endogenous Ovarian Activity
title_fullStr	Hormonal Characteristics of Women Receiving Ovarian Tissue Transplantation with or without Endogenous Ovarian Activity
title_full_unstemmed	Hormonal Characteristics of Women Receiving Ovarian Tissue Transplantation with or without Endogenous Ovarian Activity
title_sort	hormonal characteristics of women receiving ovarian tissue transplantation with or without endogenous ovarian activity
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/9b751f35c5d3466a8a4d03c4e974c942
work_keys_str_mv	AT vinniehornshøjgreve hormonalcharacteristicsofwomenreceivingovariantissuetransplantationwithorwithoutendogenousovarianactivity AT margitdueholm hormonalcharacteristicsofwomenreceivingovariantissuetransplantationwithorwithoutendogenousovarianactivity AT linnsaltomamsen hormonalcharacteristicsofwomenreceivingovariantissuetransplantationwithorwithoutendogenousovarianactivity AT stinegrykristensen hormonalcharacteristicsofwomenreceivingovariantissuetransplantationwithorwithoutendogenousovarianactivity AT erikernst hormonalcharacteristicsofwomenreceivingovariantissuetransplantationwithorwithoutendogenousovarianactivity AT clausydingandersen hormonalcharacteristicsofwomenreceivingovariantissuetransplantationwithorwithoutendogenousovarianactivity
_version_	1718411762282266624

Hormonal Characteristics of Women Receiving Ovarian Tissue Transplantation with or without Endogenous Ovarian Activity

Ejemplares similares