Sleep increases chromosome dynamics to enable reduction of accumulating DNA damage in single neurons

Do single neurons require sleep and what is the conserved cellular function of sleep? In this paper, the authors use real-time imaging of chromosomes in individual cells within live zebrafish to show that sleep increases chromosome dynamics, which are necessary to reduce DNA damage that is accumulat...

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Autores principales: D. Zada, I. Bronshtein, T. Lerer-Goldshtein, Y. Garini, L. Appelbaum
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/9b7b04d73cef480984f4f2a778b059ff
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Sumario:Do single neurons require sleep and what is the conserved cellular function of sleep? In this paper, the authors use real-time imaging of chromosomes in individual cells within live zebrafish to show that sleep increases chromosome dynamics, which are necessary to reduce DNA damage that is accumulated during wakefulness.