Sleep increases chromosome dynamics to enable reduction of accumulating DNA damage in single neurons

Do single neurons require sleep and what is the conserved cellular function of sleep? In this paper, the authors use real-time imaging of chromosomes in individual cells within live zebrafish to show that sleep increases chromosome dynamics, which are necessary to reduce DNA damage that is accumulat...

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Autores principales:	D. Zada, I. Bronshtein, T. Lerer-Goldshtein, Y. Garini, L. Appelbaum
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9b7b04d73cef480984f4f2a778b059ff
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spelling	oai:doaj.org-article:9b7b04d73cef480984f4f2a778b059ff2021-12-02T15:35:15ZSleep increases chromosome dynamics to enable reduction of accumulating DNA damage in single neurons10.1038/s41467-019-08806-w2041-1723https://doaj.org/article/9b7b04d73cef480984f4f2a778b059ff2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08806-whttps://doaj.org/toc/2041-1723Do single neurons require sleep and what is the conserved cellular function of sleep? In this paper, the authors use real-time imaging of chromosomes in individual cells within live zebrafish to show that sleep increases chromosome dynamics, which are necessary to reduce DNA damage that is accumulated during wakefulness.D. ZadaI. BronshteinT. Lerer-GoldshteinY. GariniL. AppelbaumNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q D. Zada I. Bronshtein T. Lerer-Goldshtein Y. Garini L. Appelbaum Sleep increases chromosome dynamics to enable reduction of accumulating DNA damage in single neurons
description	Do single neurons require sleep and what is the conserved cellular function of sleep? In this paper, the authors use real-time imaging of chromosomes in individual cells within live zebrafish to show that sleep increases chromosome dynamics, which are necessary to reduce DNA damage that is accumulated during wakefulness.
format	article
author	D. Zada I. Bronshtein T. Lerer-Goldshtein Y. Garini L. Appelbaum
author_facet	D. Zada I. Bronshtein T. Lerer-Goldshtein Y. Garini L. Appelbaum
author_sort	D. Zada
title	Sleep increases chromosome dynamics to enable reduction of accumulating DNA damage in single neurons
title_short	Sleep increases chromosome dynamics to enable reduction of accumulating DNA damage in single neurons
title_full	Sleep increases chromosome dynamics to enable reduction of accumulating DNA damage in single neurons
title_fullStr	Sleep increases chromosome dynamics to enable reduction of accumulating DNA damage in single neurons
title_full_unstemmed	Sleep increases chromosome dynamics to enable reduction of accumulating DNA damage in single neurons
title_sort	sleep increases chromosome dynamics to enable reduction of accumulating dna damage in single neurons
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/9b7b04d73cef480984f4f2a778b059ff
work_keys_str_mv	AT dzada sleepincreaseschromosomedynamicstoenablereductionofaccumulatingdnadamageinsingleneurons AT ibronshtein sleepincreaseschromosomedynamicstoenablereductionofaccumulatingdnadamageinsingleneurons AT tlerergoldshtein sleepincreaseschromosomedynamicstoenablereductionofaccumulatingdnadamageinsingleneurons AT ygarini sleepincreaseschromosomedynamicstoenablereductionofaccumulatingdnadamageinsingleneurons AT lappelbaum sleepincreaseschromosomedynamicstoenablereductionofaccumulatingdnadamageinsingleneurons
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Sleep increases chromosome dynamics to enable reduction of accumulating DNA damage in single neurons

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