Association of vitamin D status and cardio-metabolic risk factors in children and adolescents: the CASPIAN-V study

Abstract Background Metabolic syndrome (MetS) starts from early life and is one of the important underlying factors for non-communicable diseases (NCDs) in adulthood. Controversial evidence exists on the role of vitamin D deficiency in increasing the risk of pediatric MetS. Objective This study aime...

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Autores principales:	Mostafa Qorbani, Motahar Heidari-Beni, Hanieh-Sadat Ejtahed, Gita Shafiee, Farid Goodarzi, Seyed Saeed Tamehri Zadeh, Majid Khademian, Nami Mohammadian Khonsari, Mohammad Esmaeil Motlagh, Hamid Asayesh, Mohammad Jabbari, Ramin Heshmat, Mehdi Ebrahimi, Roya Kelishadi
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Vitamin D Metabolic syndrome Children Adolescents Nutrition. Foods and food supply TX341-641 Food processing and manufacture TP368-456 Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/9b7d3d924b724ac9a0ae3354cc3e8160
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spelling	oai:doaj.org-article:9b7d3d924b724ac9a0ae3354cc3e81602021-11-21T12:13:51ZAssociation of vitamin D status and cardio-metabolic risk factors in children and adolescents: the CASPIAN-V study10.1186/s40795-021-00477-52055-0928https://doaj.org/article/9b7d3d924b724ac9a0ae3354cc3e81602021-11-01T00:00:00Zhttps://doi.org/10.1186/s40795-021-00477-5https://doaj.org/toc/2055-0928Abstract Background Metabolic syndrome (MetS) starts from early life and is one of the important underlying factors for non-communicable diseases (NCDs) in adulthood. Controversial evidence exists on the role of vitamin D deficiency in increasing the risk of pediatric MetS. Objective This study aimed to assess the relationship between vitamin D level with MetS and its components in children and adolescents. Methods This nationwide cross-sectional study was performed as part of a surveillance program in Iran. Participants were 2596 students, aged 7 to 18 years, living in 30 provinces. In addition to filling questionnaires, a physical examination was conducted, and blood samples were collected. The serum concentration of 25-hydroxy vitamin D (25(OH)D) was measured using the direct competitive immunoassay chemiluminescence method. Results 2596 students with a mean age of 12.2 y (55.1% boys) were recruited. Prevalence of vitamin D deficiency and insufficiency in participants was 10.6% (n = 276), and 60.5% (n = 1570), respectively. The prevalence of MetS was higher in the vitamin D deficient group. Students with deficient vitamin D levels had higher odds of MetS (OR: 4.25, 95%CI: 2.26–7.98), abdominal obesity (OR: 2.24, 95%CI: 1.61–3.12), low HDL-C (OR: 1.65, 95%CI: 1.18–2.30) and high fasting blood sugar (OR: 2.56, 95%CI: 1.43–4.57) in comparison to those with sufficient level of vitamin D. Conclusion Vitamin D deficiency was associated with increased odds of MetS and its components in the Iranian pediatric population. These findings underscore the importance of prevention and control of vitamin D deficiency in preventative programs against NCDs.Mostafa QorbaniMotahar Heidari-BeniHanieh-Sadat EjtahedGita ShafieeFarid GoodarziSeyed Saeed Tamehri ZadehMajid KhademianNami Mohammadian KhonsariMohammad Esmaeil MotlaghHamid AsayeshMohammad JabbariRamin HeshmatMehdi EbrahimiRoya KelishadiBMCarticleVitamin DMetabolic syndromeChildrenAdolescentsNutrition. Foods and food supplyTX341-641Food processing and manufactureTP368-456Medicine (General)R5-920ENBMC Nutrition, Vol 7, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Vitamin D Metabolic syndrome Children Adolescents Nutrition. Foods and food supply TX341-641 Food processing and manufacture TP368-456 Medicine (General) R5-920
spellingShingle	Vitamin D Metabolic syndrome Children Adolescents Nutrition. Foods and food supply TX341-641 Food processing and manufacture TP368-456 Medicine (General) R5-920 Mostafa Qorbani Motahar Heidari-Beni Hanieh-Sadat Ejtahed Gita Shafiee Farid Goodarzi Seyed Saeed Tamehri Zadeh Majid Khademian Nami Mohammadian Khonsari Mohammad Esmaeil Motlagh Hamid Asayesh Mohammad Jabbari Ramin Heshmat Mehdi Ebrahimi Roya Kelishadi Association of vitamin D status and cardio-metabolic risk factors in children and adolescents: the CASPIAN-V study
description	Abstract Background Metabolic syndrome (MetS) starts from early life and is one of the important underlying factors for non-communicable diseases (NCDs) in adulthood. Controversial evidence exists on the role of vitamin D deficiency in increasing the risk of pediatric MetS. Objective This study aimed to assess the relationship between vitamin D level with MetS and its components in children and adolescents. Methods This nationwide cross-sectional study was performed as part of a surveillance program in Iran. Participants were 2596 students, aged 7 to 18 years, living in 30 provinces. In addition to filling questionnaires, a physical examination was conducted, and blood samples were collected. The serum concentration of 25-hydroxy vitamin D (25(OH)D) was measured using the direct competitive immunoassay chemiluminescence method. Results 2596 students with a mean age of 12.2 y (55.1% boys) were recruited. Prevalence of vitamin D deficiency and insufficiency in participants was 10.6% (n = 276), and 60.5% (n = 1570), respectively. The prevalence of MetS was higher in the vitamin D deficient group. Students with deficient vitamin D levels had higher odds of MetS (OR: 4.25, 95%CI: 2.26–7.98), abdominal obesity (OR: 2.24, 95%CI: 1.61–3.12), low HDL-C (OR: 1.65, 95%CI: 1.18–2.30) and high fasting blood sugar (OR: 2.56, 95%CI: 1.43–4.57) in comparison to those with sufficient level of vitamin D. Conclusion Vitamin D deficiency was associated with increased odds of MetS and its components in the Iranian pediatric population. These findings underscore the importance of prevention and control of vitamin D deficiency in preventative programs against NCDs.
format	article
author	Mostafa Qorbani Motahar Heidari-Beni Hanieh-Sadat Ejtahed Gita Shafiee Farid Goodarzi Seyed Saeed Tamehri Zadeh Majid Khademian Nami Mohammadian Khonsari Mohammad Esmaeil Motlagh Hamid Asayesh Mohammad Jabbari Ramin Heshmat Mehdi Ebrahimi Roya Kelishadi
author_facet	Mostafa Qorbani Motahar Heidari-Beni Hanieh-Sadat Ejtahed Gita Shafiee Farid Goodarzi Seyed Saeed Tamehri Zadeh Majid Khademian Nami Mohammadian Khonsari Mohammad Esmaeil Motlagh Hamid Asayesh Mohammad Jabbari Ramin Heshmat Mehdi Ebrahimi Roya Kelishadi
author_sort	Mostafa Qorbani
title	Association of vitamin D status and cardio-metabolic risk factors in children and adolescents: the CASPIAN-V study
title_short	Association of vitamin D status and cardio-metabolic risk factors in children and adolescents: the CASPIAN-V study
title_full	Association of vitamin D status and cardio-metabolic risk factors in children and adolescents: the CASPIAN-V study
title_fullStr	Association of vitamin D status and cardio-metabolic risk factors in children and adolescents: the CASPIAN-V study
title_full_unstemmed	Association of vitamin D status and cardio-metabolic risk factors in children and adolescents: the CASPIAN-V study
title_sort	association of vitamin d status and cardio-metabolic risk factors in children and adolescents: the caspian-v study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/9b7d3d924b724ac9a0ae3354cc3e8160
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Association of vitamin D status and cardio-metabolic risk factors in children and adolescents: the CASPIAN-V study

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