Practice Guidelines of the Central European Hepatologic Collaboration (CEHC) on the Use of Thrombopoietin Receptor Agonists in Patients with Chronic Liver Disease Undergoing Invasive Procedures

Background: Second-generation thrombopoietin receptor agonists (TPO-RAs) are emerging as the new standard for managing thrombocytopenia (TCP) in patients with chronic liver diseases (CLDs) undergoing scheduled procedures. However, practical guidance for their routine use in CLD patients undergoing s...

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Autores principales: Robert Flisiak, Krasimir Antonov, Pavel Drastich, Peter Jarcuska, Marina Maevskaya, Mihály Makara, Željko Puljiz, Borut Štabuc, Anca Trifan
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spelling oai:doaj.org-article:9b8263fcddf5497b91835f71ec4c51632021-11-25T18:02:37ZPractice Guidelines of the Central European Hepatologic Collaboration (CEHC) on the Use of Thrombopoietin Receptor Agonists in Patients with Chronic Liver Disease Undergoing Invasive Procedures10.3390/jcm102254192077-0383https://doaj.org/article/9b8263fcddf5497b91835f71ec4c51632021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5419https://doaj.org/toc/2077-0383Background: Second-generation thrombopoietin receptor agonists (TPO-RAs) are emerging as the new standard for managing thrombocytopenia (TCP) in patients with chronic liver diseases (CLDs) undergoing scheduled procedures. However, practical guidance for their routine use in CLD patients undergoing specific invasive procedures is lacking. Methods: These practice guidelines were developed by the Initiative Group for Central European Hepatologic Collaboration (CEHC), composed of nine hepatologist/gastroenterologist experts from Central Europe. Using an adapted Delphi process, the CEHC group selected ten invasive procedures most relevant to the hepatology/gastroenterology setting in the region. Consensus recommendations for each invasive procedure are reported as a final percentage of expert panel responses. Results: A consensus was agreed that TPO-RAs should be considered for raising platelet count in CLD patients undergoing scheduled abdominal surgery, high-bleeding risk dentistry, endoscopic polypectomy, endoscopic variceal ligation, liver biopsy, liver surgery, liver transplantation and percutaneous ablation, but it was also agreed that they are less beneficial or not necessary for endoscopy without intervention and paracentesis. Conclusions: Using a modified Delphi method, experts reached an agreement for TCP management in CLD patients undergoing ten invasive procedures. These practice guidelines may help with decision making and patient management in areas where clinical evidence is absent or limited.Robert FlisiakKrasimir AntonovPavel DrastichPeter JarcuskaMarina MaevskayaMihály MakaraŽeljko PuljizBorut ŠtabucAnca TrifanMDPI AGarticlechronic liver diseaseavatrombopagthrombocytopeniasurgical proceduresthrombopoietin receptor agonistsplatelet transfusionMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5419, p 5419 (2021)
institution DOAJ
collection DOAJ
language EN
topic chronic liver disease
avatrombopag
thrombocytopenia
surgical procedures
thrombopoietin receptor agonists
platelet transfusion
Medicine
R
spellingShingle chronic liver disease
avatrombopag
thrombocytopenia
surgical procedures
thrombopoietin receptor agonists
platelet transfusion
Medicine
R
Robert Flisiak
Krasimir Antonov
Pavel Drastich
Peter Jarcuska
Marina Maevskaya
Mihály Makara
Željko Puljiz
Borut Štabuc
Anca Trifan
Practice Guidelines of the Central European Hepatologic Collaboration (CEHC) on the Use of Thrombopoietin Receptor Agonists in Patients with Chronic Liver Disease Undergoing Invasive Procedures
description Background: Second-generation thrombopoietin receptor agonists (TPO-RAs) are emerging as the new standard for managing thrombocytopenia (TCP) in patients with chronic liver diseases (CLDs) undergoing scheduled procedures. However, practical guidance for their routine use in CLD patients undergoing specific invasive procedures is lacking. Methods: These practice guidelines were developed by the Initiative Group for Central European Hepatologic Collaboration (CEHC), composed of nine hepatologist/gastroenterologist experts from Central Europe. Using an adapted Delphi process, the CEHC group selected ten invasive procedures most relevant to the hepatology/gastroenterology setting in the region. Consensus recommendations for each invasive procedure are reported as a final percentage of expert panel responses. Results: A consensus was agreed that TPO-RAs should be considered for raising platelet count in CLD patients undergoing scheduled abdominal surgery, high-bleeding risk dentistry, endoscopic polypectomy, endoscopic variceal ligation, liver biopsy, liver surgery, liver transplantation and percutaneous ablation, but it was also agreed that they are less beneficial or not necessary for endoscopy without intervention and paracentesis. Conclusions: Using a modified Delphi method, experts reached an agreement for TCP management in CLD patients undergoing ten invasive procedures. These practice guidelines may help with decision making and patient management in areas where clinical evidence is absent or limited.
format article
author Robert Flisiak
Krasimir Antonov
Pavel Drastich
Peter Jarcuska
Marina Maevskaya
Mihály Makara
Željko Puljiz
Borut Štabuc
Anca Trifan
author_facet Robert Flisiak
Krasimir Antonov
Pavel Drastich
Peter Jarcuska
Marina Maevskaya
Mihály Makara
Željko Puljiz
Borut Štabuc
Anca Trifan
author_sort Robert Flisiak
title Practice Guidelines of the Central European Hepatologic Collaboration (CEHC) on the Use of Thrombopoietin Receptor Agonists in Patients with Chronic Liver Disease Undergoing Invasive Procedures
title_short Practice Guidelines of the Central European Hepatologic Collaboration (CEHC) on the Use of Thrombopoietin Receptor Agonists in Patients with Chronic Liver Disease Undergoing Invasive Procedures
title_full Practice Guidelines of the Central European Hepatologic Collaboration (CEHC) on the Use of Thrombopoietin Receptor Agonists in Patients with Chronic Liver Disease Undergoing Invasive Procedures
title_fullStr Practice Guidelines of the Central European Hepatologic Collaboration (CEHC) on the Use of Thrombopoietin Receptor Agonists in Patients with Chronic Liver Disease Undergoing Invasive Procedures
title_full_unstemmed Practice Guidelines of the Central European Hepatologic Collaboration (CEHC) on the Use of Thrombopoietin Receptor Agonists in Patients with Chronic Liver Disease Undergoing Invasive Procedures
title_sort practice guidelines of the central european hepatologic collaboration (cehc) on the use of thrombopoietin receptor agonists in patients with chronic liver disease undergoing invasive procedures
publisher MDPI AG
publishDate 2021
url https://doaj.org/article/9b8263fcddf5497b91835f71ec4c5163
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