Oridonin Dose-Dependently Modulates the Cell Senescence and Apoptosis of Gastric Cancer Cells

Gastric cancer (GC) is the fourth most lethal cancer. Effective treatments are lacking, and our knowledge of the pathogenic mechanisms in play is poor. Oridonin from the Chinese herb Rabdosia rubescens exerts various anticancer activities. However, the dose-dependent effects of oridonin on human GC...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yiping Wang, Hang Lv, Chunyan Dai, Xi Wang, Yifei Yin, Zhe Chen
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Other systems of medicine RZ201-999
Acceso en línea:	https://doaj.org/article/9b86f53293254bd190db919098a64d17
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9b86f53293254bd190db919098a64d17
record_format	dspace
spelling	oai:doaj.org-article:9b86f53293254bd190db919098a64d172021-11-22T01:09:43ZOridonin Dose-Dependently Modulates the Cell Senescence and Apoptosis of Gastric Cancer Cells1741-428810.1155/2021/5023536https://doaj.org/article/9b86f53293254bd190db919098a64d172021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/5023536https://doaj.org/toc/1741-4288Gastric cancer (GC) is the fourth most lethal cancer. Effective treatments are lacking, and our knowledge of the pathogenic mechanisms in play is poor. Oridonin from the Chinese herb Rabdosia rubescens exerts various anticancer activities. However, the dose-dependent effects of oridonin on human GC remain unclear. Here, we found that oridonin inhibited GC cell growth in a time- and dose-dependent manner. Low-dose oridonin induced GC cell cycle arrest at G0/G1 and cell senescence by suppressing the c-Myc-AP4 pathway and enhancing p53-p21 signaling. AP4 overexpression partly abrogated the oridonin-induced senescence of GC cells. High-dose oridonin induced apoptosis and autophagy, with the autophagy inhibitor BafA1 attenuating oridonin-induced apoptosis. Together, the findings indicate that oridonin at different doses modulates GC cell senescence and apoptosis; oridonin may thus usefully treat GC.Yiping WangHang LvChunyan DaiXi WangYifei YinZhe ChenHindawi LimitedarticleOther systems of medicineRZ201-999ENEvidence-Based Complementary and Alternative Medicine, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Other systems of medicine RZ201-999
spellingShingle	Other systems of medicine RZ201-999 Yiping Wang Hang Lv Chunyan Dai Xi Wang Yifei Yin Zhe Chen Oridonin Dose-Dependently Modulates the Cell Senescence and Apoptosis of Gastric Cancer Cells
description	Gastric cancer (GC) is the fourth most lethal cancer. Effective treatments are lacking, and our knowledge of the pathogenic mechanisms in play is poor. Oridonin from the Chinese herb Rabdosia rubescens exerts various anticancer activities. However, the dose-dependent effects of oridonin on human GC remain unclear. Here, we found that oridonin inhibited GC cell growth in a time- and dose-dependent manner. Low-dose oridonin induced GC cell cycle arrest at G0/G1 and cell senescence by suppressing the c-Myc-AP4 pathway and enhancing p53-p21 signaling. AP4 overexpression partly abrogated the oridonin-induced senescence of GC cells. High-dose oridonin induced apoptosis and autophagy, with the autophagy inhibitor BafA1 attenuating oridonin-induced apoptosis. Together, the findings indicate that oridonin at different doses modulates GC cell senescence and apoptosis; oridonin may thus usefully treat GC.
format	article
author	Yiping Wang Hang Lv Chunyan Dai Xi Wang Yifei Yin Zhe Chen
author_facet	Yiping Wang Hang Lv Chunyan Dai Xi Wang Yifei Yin Zhe Chen
author_sort	Yiping Wang
title	Oridonin Dose-Dependently Modulates the Cell Senescence and Apoptosis of Gastric Cancer Cells
title_short	Oridonin Dose-Dependently Modulates the Cell Senescence and Apoptosis of Gastric Cancer Cells
title_full	Oridonin Dose-Dependently Modulates the Cell Senescence and Apoptosis of Gastric Cancer Cells
title_fullStr	Oridonin Dose-Dependently Modulates the Cell Senescence and Apoptosis of Gastric Cancer Cells
title_full_unstemmed	Oridonin Dose-Dependently Modulates the Cell Senescence and Apoptosis of Gastric Cancer Cells
title_sort	oridonin dose-dependently modulates the cell senescence and apoptosis of gastric cancer cells
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/9b86f53293254bd190db919098a64d17
work_keys_str_mv	AT yipingwang oridonindosedependentlymodulatesthecellsenescenceandapoptosisofgastriccancercells AT hanglv oridonindosedependentlymodulatesthecellsenescenceandapoptosisofgastriccancercells AT chunyandai oridonindosedependentlymodulatesthecellsenescenceandapoptosisofgastriccancercells AT xiwang oridonindosedependentlymodulatesthecellsenescenceandapoptosisofgastriccancercells AT yifeiyin oridonindosedependentlymodulatesthecellsenescenceandapoptosisofgastriccancercells AT zhechen oridonindosedependentlymodulatesthecellsenescenceandapoptosisofgastriccancercells
_version_	1718418414987378688

Oridonin Dose-Dependently Modulates the Cell Senescence and Apoptosis of Gastric Cancer Cells

Ejemplares similares