Hematological and Hematopoietic Effects of Bactericidal Doses of Trans-Cinnamaldehyde and Thyme Oil on Cyprinus carpio Juveniles

The effects of two potential antibacterial agents of plant origin: trans-cinnamaldehyde (TC) and thyme oil (TO) on the peripheral blood parameters and cellular composition of hematopoietic tissue of Cyprinus carpio were studied. Both phytochemicals were used in the doses based on the bactericidal co...

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Autores principales:	Elżbieta Kondera, Bartosz Bojarski, Katarzyna Ługowska, Barbara Kot, Małgorzata Witeska
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	phytochemicals fish toxicity blood head kidney Physiology QP1-981
Acceso en línea:	https://doaj.org/article/9b87d1db7d4843188d659b86d25d097a
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spelling	oai:doaj.org-article:9b87d1db7d4843188d659b86d25d097a2021-11-30T18:24:56ZHematological and Hematopoietic Effects of Bactericidal Doses of Trans-Cinnamaldehyde and Thyme Oil on Cyprinus carpio Juveniles1664-042X10.3389/fphys.2021.771243https://doaj.org/article/9b87d1db7d4843188d659b86d25d097a2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphys.2021.771243/fullhttps://doaj.org/toc/1664-042XThe effects of two potential antibacterial agents of plant origin: trans-cinnamaldehyde (TC) and thyme oil (TO) on the peripheral blood parameters and cellular composition of hematopoietic tissue of Cyprinus carpio were studied. Both phytochemicals were used in the doses based on the bactericidal concentrations against Aeromonas spp. developed earlier in in vitro study. The fish were fed for 2 weeks on a commercial feed supplemented with 10 μl/kg of TC or 20 μl/kg of TO. Groups TC1 and TO1 were fed diets containing phytochemicals daily, while groups TC2 and TO2 every 2 days. Control group and groups TC2 and TO2 on the remaining days were fed plain feed. Peripheral blood and head kidney hematopoietic tissue were sampled from all the fish at the end of the experiment. In all the groups, hematological values were within the reference ranges for the healthy common carp juveniles. However, blood hemoglobin (Hb) concentration and mean corpuscular hemoglobin concentration (MCHC) were significantly lower in all the groups exposed to TC and TO, while MCH in TC1, TO1, and TO2 compared to the control. TC and TO did not affect leukocyte count [white blood cell (WBC)], differential leukocyte count, the oxidative activity of phagocytes [nitroblue tetrazolium (NBT)], or thrombocyte count (Thro). No significant alterations were observed in the hematopoietic tissue. The results showed that TC and TO exhibited no considerable hematotoxic effects and trials of their use in the treatment of fish infected with Aeromonas spp. may be undertaken.Elżbieta KonderaBartosz BojarskiKatarzyna ŁugowskaBarbara KotMałgorzata WiteskaFrontiers Media S.A.articlephytochemicalsfishtoxicitybloodhead kidneyPhysiologyQP1-981ENFrontiers in Physiology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	phytochemicals fish toxicity blood head kidney Physiology QP1-981
spellingShingle	phytochemicals fish toxicity blood head kidney Physiology QP1-981 Elżbieta Kondera Bartosz Bojarski Katarzyna Ługowska Barbara Kot Małgorzata Witeska Hematological and Hematopoietic Effects of Bactericidal Doses of Trans-Cinnamaldehyde and Thyme Oil on Cyprinus carpio Juveniles
description	The effects of two potential antibacterial agents of plant origin: trans-cinnamaldehyde (TC) and thyme oil (TO) on the peripheral blood parameters and cellular composition of hematopoietic tissue of Cyprinus carpio were studied. Both phytochemicals were used in the doses based on the bactericidal concentrations against Aeromonas spp. developed earlier in in vitro study. The fish were fed for 2 weeks on a commercial feed supplemented with 10 μl/kg of TC or 20 μl/kg of TO. Groups TC1 and TO1 were fed diets containing phytochemicals daily, while groups TC2 and TO2 every 2 days. Control group and groups TC2 and TO2 on the remaining days were fed plain feed. Peripheral blood and head kidney hematopoietic tissue were sampled from all the fish at the end of the experiment. In all the groups, hematological values were within the reference ranges for the healthy common carp juveniles. However, blood hemoglobin (Hb) concentration and mean corpuscular hemoglobin concentration (MCHC) were significantly lower in all the groups exposed to TC and TO, while MCH in TC1, TO1, and TO2 compared to the control. TC and TO did not affect leukocyte count [white blood cell (WBC)], differential leukocyte count, the oxidative activity of phagocytes [nitroblue tetrazolium (NBT)], or thrombocyte count (Thro). No significant alterations were observed in the hematopoietic tissue. The results showed that TC and TO exhibited no considerable hematotoxic effects and trials of their use in the treatment of fish infected with Aeromonas spp. may be undertaken.
format	article
author	Elżbieta Kondera Bartosz Bojarski Katarzyna Ługowska Barbara Kot Małgorzata Witeska
author_facet	Elżbieta Kondera Bartosz Bojarski Katarzyna Ługowska Barbara Kot Małgorzata Witeska
author_sort	Elżbieta Kondera
title	Hematological and Hematopoietic Effects of Bactericidal Doses of Trans-Cinnamaldehyde and Thyme Oil on Cyprinus carpio Juveniles
title_short	Hematological and Hematopoietic Effects of Bactericidal Doses of Trans-Cinnamaldehyde and Thyme Oil on Cyprinus carpio Juveniles
title_full	Hematological and Hematopoietic Effects of Bactericidal Doses of Trans-Cinnamaldehyde and Thyme Oil on Cyprinus carpio Juveniles
title_fullStr	Hematological and Hematopoietic Effects of Bactericidal Doses of Trans-Cinnamaldehyde and Thyme Oil on Cyprinus carpio Juveniles
title_full_unstemmed	Hematological and Hematopoietic Effects of Bactericidal Doses of Trans-Cinnamaldehyde and Thyme Oil on Cyprinus carpio Juveniles
title_sort	hematological and hematopoietic effects of bactericidal doses of trans-cinnamaldehyde and thyme oil on cyprinus carpio juveniles
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/9b87d1db7d4843188d659b86d25d097a
work_keys_str_mv	AT elzbietakondera hematologicalandhematopoieticeffectsofbactericidaldosesoftranscinnamaldehydeandthymeoiloncyprinuscarpiojuveniles AT bartoszbojarski hematologicalandhematopoieticeffectsofbactericidaldosesoftranscinnamaldehydeandthymeoiloncyprinuscarpiojuveniles AT katarzynaługowska hematologicalandhematopoieticeffectsofbactericidaldosesoftranscinnamaldehydeandthymeoiloncyprinuscarpiojuveniles AT barbarakot hematologicalandhematopoieticeffectsofbactericidaldosesoftranscinnamaldehydeandthymeoiloncyprinuscarpiojuveniles AT małgorzatawiteska hematologicalandhematopoieticeffectsofbactericidaldosesoftranscinnamaldehydeandthymeoiloncyprinuscarpiojuveniles
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Hematological and Hematopoietic Effects of Bactericidal Doses of Trans-Cinnamaldehyde and Thyme Oil on Cyprinus carpio Juveniles

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