Oral Administration of East Asian Herbal Medicine for Peripheral Neuropathy: A Systematic Review and Meta-Analysis with Association Rule Analysis to Identify Core Herb Combinations

This review aimed to comprehensively assess the efficacy and safety of oral East Asian herbal medicine (EAHM) for overall peripheral neuropathy (PN). In addition, an Apriori algorithm-based association rule analysis was performed to identify the core herb combination, thereby further generating usef...

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Autores principales:	Hee-Geun Jo, Donghun Lee
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	association rule analysis complementary and alternative medicine East Asian herbal medicine meta-analysis peripheral neuropathy systematic review Medicine R Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/9b88bb5f7db84590924226cbca4228b9
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spelling	oai:doaj.org-article:9b88bb5f7db84590924226cbca4228b92021-11-25T18:40:11ZOral Administration of East Asian Herbal Medicine for Peripheral Neuropathy: A Systematic Review and Meta-Analysis with Association Rule Analysis to Identify Core Herb Combinations10.3390/ph141112021424-8247https://doaj.org/article/9b88bb5f7db84590924226cbca4228b92021-11-01T00:00:00Zhttps://www.mdpi.com/1424-8247/14/11/1202https://doaj.org/toc/1424-8247This review aimed to comprehensively assess the efficacy and safety of oral East Asian herbal medicine (EAHM) for overall peripheral neuropathy (PN). In addition, an Apriori algorithm-based association rule analysis was performed to identify the core herb combination, thereby further generating useful hypotheses for subsequent drug discovery. A total of 10 databases were searched electronically from inception to July 2021. Randomized clinical trials (RCTs) comparing EAHM with conventional analgesic medication or usual care for managing PN were included. The RCT quality was appraised using RoB 2.0, and the random effects model was used to calculate the effect sizes of the included RCTs. The overall quality of evidence was evaluated according to the Grading of Recommendations Assessment, Development, and Evaluation. By analyzing the constituent herb data, the potential association rules of core herb combinations were explored. A total of 67 RCTs involving 5753 patients were included in this systematic review. In a meta-analysis, EAHM monotherapy and combined EAHM and western medicine therapy demonstrated substantially improved sensory nerve conduction velocity, motor nerve conduction velocity, and response rate. Moreover, EAHM significantly improved the incidence rate, pain intensity, Toronto clinical scoring system, and Michigan diabetic neuropathy score. The evidence grade was moderate to low due to the substantial heterogeneity among the studies. Nine association rules were identified by performing the association rule analysis on the extraction data of 156 EAHM herbs. Therefore, the constituents of the herb combinations with consistent association rules were Astragali Radix, Cinnamomi Ramulus, and Spatholobi Calulis. This meta-analysis supports the hypothesis that EAHM monotherapy and combined therapy may be beneficial for PN patients, and follow-up research should be conducted to confirm the precise action target of the core herb.Hee-Geun JoDonghun LeeMDPI AGarticleassociation rule analysiscomplementary and alternative medicineEast Asian herbal medicinemeta-analysisperipheral neuropathysystematic reviewMedicineRPharmacy and materia medicaRS1-441ENPharmaceuticals, Vol 14, Iss 1202, p 1202 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	association rule analysis complementary and alternative medicine East Asian herbal medicine meta-analysis peripheral neuropathy systematic review Medicine R Pharmacy and materia medica RS1-441
spellingShingle	association rule analysis complementary and alternative medicine East Asian herbal medicine meta-analysis peripheral neuropathy systematic review Medicine R Pharmacy and materia medica RS1-441 Hee-Geun Jo Donghun Lee Oral Administration of East Asian Herbal Medicine for Peripheral Neuropathy: A Systematic Review and Meta-Analysis with Association Rule Analysis to Identify Core Herb Combinations
description	This review aimed to comprehensively assess the efficacy and safety of oral East Asian herbal medicine (EAHM) for overall peripheral neuropathy (PN). In addition, an Apriori algorithm-based association rule analysis was performed to identify the core herb combination, thereby further generating useful hypotheses for subsequent drug discovery. A total of 10 databases were searched electronically from inception to July 2021. Randomized clinical trials (RCTs) comparing EAHM with conventional analgesic medication or usual care for managing PN were included. The RCT quality was appraised using RoB 2.0, and the random effects model was used to calculate the effect sizes of the included RCTs. The overall quality of evidence was evaluated according to the Grading of Recommendations Assessment, Development, and Evaluation. By analyzing the constituent herb data, the potential association rules of core herb combinations were explored. A total of 67 RCTs involving 5753 patients were included in this systematic review. In a meta-analysis, EAHM monotherapy and combined EAHM and western medicine therapy demonstrated substantially improved sensory nerve conduction velocity, motor nerve conduction velocity, and response rate. Moreover, EAHM significantly improved the incidence rate, pain intensity, Toronto clinical scoring system, and Michigan diabetic neuropathy score. The evidence grade was moderate to low due to the substantial heterogeneity among the studies. Nine association rules were identified by performing the association rule analysis on the extraction data of 156 EAHM herbs. Therefore, the constituents of the herb combinations with consistent association rules were Astragali Radix, Cinnamomi Ramulus, and Spatholobi Calulis. This meta-analysis supports the hypothesis that EAHM monotherapy and combined therapy may be beneficial for PN patients, and follow-up research should be conducted to confirm the precise action target of the core herb.
format	article
author	Hee-Geun Jo Donghun Lee
author_facet	Hee-Geun Jo Donghun Lee
author_sort	Hee-Geun Jo
title	Oral Administration of East Asian Herbal Medicine for Peripheral Neuropathy: A Systematic Review and Meta-Analysis with Association Rule Analysis to Identify Core Herb Combinations
title_short	Oral Administration of East Asian Herbal Medicine for Peripheral Neuropathy: A Systematic Review and Meta-Analysis with Association Rule Analysis to Identify Core Herb Combinations
title_full	Oral Administration of East Asian Herbal Medicine for Peripheral Neuropathy: A Systematic Review and Meta-Analysis with Association Rule Analysis to Identify Core Herb Combinations
title_fullStr	Oral Administration of East Asian Herbal Medicine for Peripheral Neuropathy: A Systematic Review and Meta-Analysis with Association Rule Analysis to Identify Core Herb Combinations
title_full_unstemmed	Oral Administration of East Asian Herbal Medicine for Peripheral Neuropathy: A Systematic Review and Meta-Analysis with Association Rule Analysis to Identify Core Herb Combinations
title_sort	oral administration of east asian herbal medicine for peripheral neuropathy: a systematic review and meta-analysis with association rule analysis to identify core herb combinations
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/9b88bb5f7db84590924226cbca4228b9
work_keys_str_mv	AT heegeunjo oraladministrationofeastasianherbalmedicineforperipheralneuropathyasystematicreviewandmetaanalysiswithassociationruleanalysistoidentifycoreherbcombinations AT donghunlee oraladministrationofeastasianherbalmedicineforperipheralneuropathyasystematicreviewandmetaanalysiswithassociationruleanalysistoidentifycoreherbcombinations
_version_	1718410852009246720

Oral Administration of East Asian Herbal Medicine for Peripheral Neuropathy: A Systematic Review and Meta-Analysis with Association Rule Analysis to Identify Core Herb Combinations

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