Spectral domain OCT versus time domain OCT in the evaluation of macular features related to wet age-related macular degeneration

Luisa Pierro1, Elena Zampedri1, Paolo Milani2, Marco Gagliardi1, Vincenzo Isola2, Alfredo Pece21Department of Ophthalmology, University Vita-Salute, Scientific Institute San Raffaele, Milano, Italy, 2Fondazione Retina 3000, Milano, ItalyBackground: The aim of this study was to compare the agreement...

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Autores principales:	Isola V, Gagliardi M, Milani P, Zampedri E, Pierro L, Pece A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/9b89aab014ae40ccb0e3089bad7ebba4
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spelling	oai:doaj.org-article:9b89aab014ae40ccb0e3089bad7ebba42021-12-02T02:57:39ZSpectral domain OCT versus time domain OCT in the evaluation of macular features related to wet age-related macular degeneration1177-54671177-5483https://doaj.org/article/9b89aab014ae40ccb0e3089bad7ebba42012-02-01T00:00:00Zhttp://www.dovepress.com/spectral-domain-oct-versus-time-domain-oct-in-the-evaluation-of-macula-a9233https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Luisa Pierro1, Elena Zampedri1, Paolo Milani2, Marco Gagliardi1, Vincenzo Isola2, Alfredo Pece21Department of Ophthalmology, University Vita-Salute, Scientific Institute San Raffaele, Milano, Italy, 2Fondazione Retina 3000, Milano, ItalyBackground: The aim of this study was to compare the agreement between spectral domain optical coherence tomography (SD OCT) and time domain stratus OCT (TD OCT) in evaluating macular morphology alterations in wet age-related macular degeneration (AMD).Methods: This retrospective study was performed on 77 eyes of 77 patients with primary or recurring subfoveal choroidal neovascularization secondary to AMD. All patients underwent OCT examination using Zeiss Stratus OCT 3 (Carl Zeiss Meditec Inc, Dublin, CA) and Opko OTI Spectral SLO/OCT (Ophthalmic Technologies Inc, Toronto, Canada). In all radial line scans, the presence of intraretinal edema (IRE), serous pigment epithelium detachment (sPED), neurosensory serous retinal detachment (NSRD), epiretinal membrane (EM), inner limiting membrane thickening (ILMT), and hard exudates (HE) were evaluated. The degree of matching was quantified by Kappa measure of agreement.Results: The percentage distribution of TD OCT findings versus SD OCT findings was: IRE 36.3% versus 77.9%, sPED 57.1% versus 85.7%, NSRD 38.9% versus 53.2%, EM 10.5% versus 26.3%, ILMT 3.8% versus 32.4%, and HE 6.4% versus 54.5%. The agreement was as follows: sPED: kappa value 0.15; NSRD: kappa value 0.61; IRE: kappa value 0.18; EM: kappa value 0.41; ILMT: kappa value 0.02; HE: kappa value 0.06.Conclusion: The agreement in the evaluation of macular lesions between the two techniques is poor and depends on the lesion considered. SD OCT allows better detection of the alterations typically related to choroidal neovascularization such as IRE, PED, ILM thickening, and HE. Consequently its use should be strongly considered in patients with wet AMD.Keywords: spectral domain, OCT, time domain, macular degeneration, AMDIsola VGagliardi MMilani PZampedri EPierro LPece ADove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2012, Iss default, Pp 219-223 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Isola V Gagliardi M Milani P Zampedri E Pierro L Pece A Spectral domain OCT versus time domain OCT in the evaluation of macular features related to wet age-related macular degeneration
description	Luisa Pierro1, Elena Zampedri1, Paolo Milani2, Marco Gagliardi1, Vincenzo Isola2, Alfredo Pece21Department of Ophthalmology, University Vita-Salute, Scientific Institute San Raffaele, Milano, Italy, 2Fondazione Retina 3000, Milano, ItalyBackground: The aim of this study was to compare the agreement between spectral domain optical coherence tomography (SD OCT) and time domain stratus OCT (TD OCT) in evaluating macular morphology alterations in wet age-related macular degeneration (AMD).Methods: This retrospective study was performed on 77 eyes of 77 patients with primary or recurring subfoveal choroidal neovascularization secondary to AMD. All patients underwent OCT examination using Zeiss Stratus OCT 3 (Carl Zeiss Meditec Inc, Dublin, CA) and Opko OTI Spectral SLO/OCT (Ophthalmic Technologies Inc, Toronto, Canada). In all radial line scans, the presence of intraretinal edema (IRE), serous pigment epithelium detachment (sPED), neurosensory serous retinal detachment (NSRD), epiretinal membrane (EM), inner limiting membrane thickening (ILMT), and hard exudates (HE) were evaluated. The degree of matching was quantified by Kappa measure of agreement.Results: The percentage distribution of TD OCT findings versus SD OCT findings was: IRE 36.3% versus 77.9%, sPED 57.1% versus 85.7%, NSRD 38.9% versus 53.2%, EM 10.5% versus 26.3%, ILMT 3.8% versus 32.4%, and HE 6.4% versus 54.5%. The agreement was as follows: sPED: kappa value 0.15; NSRD: kappa value 0.61; IRE: kappa value 0.18; EM: kappa value 0.41; ILMT: kappa value 0.02; HE: kappa value 0.06.Conclusion: The agreement in the evaluation of macular lesions between the two techniques is poor and depends on the lesion considered. SD OCT allows better detection of the alterations typically related to choroidal neovascularization such as IRE, PED, ILM thickening, and HE. Consequently its use should be strongly considered in patients with wet AMD.Keywords: spectral domain, OCT, time domain, macular degeneration, AMD
format	article
author	Isola V Gagliardi M Milani P Zampedri E Pierro L Pece A
author_facet	Isola V Gagliardi M Milani P Zampedri E Pierro L Pece A
author_sort	Isola V
title	Spectral domain OCT versus time domain OCT in the evaluation of macular features related to wet age-related macular degeneration
title_short	Spectral domain OCT versus time domain OCT in the evaluation of macular features related to wet age-related macular degeneration
title_full	Spectral domain OCT versus time domain OCT in the evaluation of macular features related to wet age-related macular degeneration
title_fullStr	Spectral domain OCT versus time domain OCT in the evaluation of macular features related to wet age-related macular degeneration
title_full_unstemmed	Spectral domain OCT versus time domain OCT in the evaluation of macular features related to wet age-related macular degeneration
title_sort	spectral domain oct versus time domain oct in the evaluation of macular features related to wet age-related macular degeneration
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/9b89aab014ae40ccb0e3089bad7ebba4
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Spectral domain OCT versus time domain OCT in the evaluation of macular features related to wet age-related macular degeneration

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