Impact of High-Altitude Hypoxia on Early Osseointegration With Bioactive Titanium

Nowadays, the bone osseointegration in different environments is comparable, but the mechanism is unclear. This study aimed to investigate the osseointegration of different bioactive titanium surfaces under normoxic or high-altitude hypoxic environments. Titanium implants were subjected to one of tw...

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Autores principales:	Yarong Wang, Zekun Gan, Haibin Lu, Ziyi Liu, Peng Shang, Jian Zhang, Wuwei Yin, Hongxing Chu, Renlei Yuan, Yingxin Ye, Pei Chen, Mingdeng Rong
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	osseointegration bioactive titanium hypoxia normoxia osteoblast Physiology QP1-981
Acceso en línea:	https://doaj.org/article/9b8b255029684b5babc18f21f9c6c7fe
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spelling	oai:doaj.org-article:9b8b255029684b5babc18f21f9c6c7fe2021-11-18T09:55:38ZImpact of High-Altitude Hypoxia on Early Osseointegration With Bioactive Titanium1664-042X10.3389/fphys.2021.689807https://doaj.org/article/9b8b255029684b5babc18f21f9c6c7fe2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphys.2021.689807/fullhttps://doaj.org/toc/1664-042XNowadays, the bone osseointegration in different environments is comparable, but the mechanism is unclear. This study aimed to investigate the osseointegration of different bioactive titanium surfaces under normoxic or high-altitude hypoxic environments. Titanium implants were subjected to one of two surface treatments: (1) sanding, blasting, and acid etching to obtain a rough surface, or (2) extensive polishing to obtain a smooth surface. Changes in the morphology, proliferation, and protein expression of osteoblasts on the rough and smooth surfaces were examined, and bone formation was studied through western blotting and animal-based experiments. Our findings found that a hypoxic environment and rough titanium implant surface promoted the osteogenic differentiation of osteoblasts and activated the JAK1/STAT1/HIF-1α pathway in vitro. The animal study revealed that following implant insertion in tibia of rabbit, bone repair at high altitudes was slower than that at low altitudes (i.e., in plains) after 2weeks; however, bone formation did not differ significantly after 4weeks. The results of our study showed that: (1) The altitude hypoxia environment would affect the early osseointegration of titanium implants while titanium implants with rough surfaces can mitigate the effects of this hypoxic environment on osseointegration, (2) the mechanism may be related to the activation of JAK1/STAT1/HIF-1α pathway, and (3) our results suggest the osteogenesis of titanium implants, such as oral implants, is closely related to the oxygen environment. Clinical doctors, especially dentists, should pay attention to the influence of hypoxia on early osseointegration in patients with high altitude. For example, it is better to choose an implant system with rough implant surface in the oral cavity of patients with tooth loss at high altitude.Yarong WangZekun GanHaibin LuZiyi LiuPeng ShangJian ZhangWuwei YinHongxing ChuRenlei YuanYingxin YePei ChenMingdeng RongFrontiers Media S.A.articleosseointegrationbioactive titaniumhypoxianormoxiaosteoblastPhysiologyQP1-981ENFrontiers in Physiology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	osseointegration bioactive titanium hypoxia normoxia osteoblast Physiology QP1-981
spellingShingle	osseointegration bioactive titanium hypoxia normoxia osteoblast Physiology QP1-981 Yarong Wang Zekun Gan Haibin Lu Ziyi Liu Peng Shang Jian Zhang Wuwei Yin Hongxing Chu Renlei Yuan Yingxin Ye Pei Chen Mingdeng Rong Impact of High-Altitude Hypoxia on Early Osseointegration With Bioactive Titanium
description	Nowadays, the bone osseointegration in different environments is comparable, but the mechanism is unclear. This study aimed to investigate the osseointegration of different bioactive titanium surfaces under normoxic or high-altitude hypoxic environments. Titanium implants were subjected to one of two surface treatments: (1) sanding, blasting, and acid etching to obtain a rough surface, or (2) extensive polishing to obtain a smooth surface. Changes in the morphology, proliferation, and protein expression of osteoblasts on the rough and smooth surfaces were examined, and bone formation was studied through western blotting and animal-based experiments. Our findings found that a hypoxic environment and rough titanium implant surface promoted the osteogenic differentiation of osteoblasts and activated the JAK1/STAT1/HIF-1α pathway in vitro. The animal study revealed that following implant insertion in tibia of rabbit, bone repair at high altitudes was slower than that at low altitudes (i.e., in plains) after 2weeks; however, bone formation did not differ significantly after 4weeks. The results of our study showed that: (1) The altitude hypoxia environment would affect the early osseointegration of titanium implants while titanium implants with rough surfaces can mitigate the effects of this hypoxic environment on osseointegration, (2) the mechanism may be related to the activation of JAK1/STAT1/HIF-1α pathway, and (3) our results suggest the osteogenesis of titanium implants, such as oral implants, is closely related to the oxygen environment. Clinical doctors, especially dentists, should pay attention to the influence of hypoxia on early osseointegration in patients with high altitude. For example, it is better to choose an implant system with rough implant surface in the oral cavity of patients with tooth loss at high altitude.
format	article
author	Yarong Wang Zekun Gan Haibin Lu Ziyi Liu Peng Shang Jian Zhang Wuwei Yin Hongxing Chu Renlei Yuan Yingxin Ye Pei Chen Mingdeng Rong
author_facet	Yarong Wang Zekun Gan Haibin Lu Ziyi Liu Peng Shang Jian Zhang Wuwei Yin Hongxing Chu Renlei Yuan Yingxin Ye Pei Chen Mingdeng Rong
author_sort	Yarong Wang
title	Impact of High-Altitude Hypoxia on Early Osseointegration With Bioactive Titanium
title_short	Impact of High-Altitude Hypoxia on Early Osseointegration With Bioactive Titanium
title_full	Impact of High-Altitude Hypoxia on Early Osseointegration With Bioactive Titanium
title_fullStr	Impact of High-Altitude Hypoxia on Early Osseointegration With Bioactive Titanium
title_full_unstemmed	Impact of High-Altitude Hypoxia on Early Osseointegration With Bioactive Titanium
title_sort	impact of high-altitude hypoxia on early osseointegration with bioactive titanium
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/9b8b255029684b5babc18f21f9c6c7fe
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Impact of High-Altitude Hypoxia on Early Osseointegration With Bioactive Titanium

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