Genetically engineering self-organization of human pluripotent stem cells into a liver bud-like tissue using Gata6
There has been limited success in generating tissues from human induced pluripotent stem cells (hiPSCs). Here, the authors genetically engineer expression of the transcription factor Gata6 in a single isogenic hiPSC population resulting in complex tissue structures that exhibit liver bud-like proper...
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Nature Portfolio
2016
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oai:doaj.org-article:9b8be1df7dff49edbe97c27e4110a2e72021-12-02T16:49:41ZGenetically engineering self-organization of human pluripotent stem cells into a liver bud-like tissue using Gata610.1038/ncomms102432041-1723https://doaj.org/article/9b8be1df7dff49edbe97c27e4110a2e72016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10243https://doaj.org/toc/2041-1723There has been limited success in generating tissues from human induced pluripotent stem cells (hiPSCs). Here, the authors genetically engineer expression of the transcription factor Gata6 in a single isogenic hiPSC population resulting in complex tissue structures that exhibit liver bud-like properties.Patrick GuyeMohammad R. EbrahimkhaniNathan KipnissJeremy J. VelazquezEldi SchoenfeldSamira KianiLinda G. GriffithRon WeissNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016) |
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Science Q Patrick Guye Mohammad R. Ebrahimkhani Nathan Kipniss Jeremy J. Velazquez Eldi Schoenfeld Samira Kiani Linda G. Griffith Ron Weiss Genetically engineering self-organization of human pluripotent stem cells into a liver bud-like tissue using Gata6 |
description |
There has been limited success in generating tissues from human induced pluripotent stem cells (hiPSCs). Here, the authors genetically engineer expression of the transcription factor Gata6 in a single isogenic hiPSC population resulting in complex tissue structures that exhibit liver bud-like properties. |
format |
article |
author |
Patrick Guye Mohammad R. Ebrahimkhani Nathan Kipniss Jeremy J. Velazquez Eldi Schoenfeld Samira Kiani Linda G. Griffith Ron Weiss |
author_facet |
Patrick Guye Mohammad R. Ebrahimkhani Nathan Kipniss Jeremy J. Velazquez Eldi Schoenfeld Samira Kiani Linda G. Griffith Ron Weiss |
author_sort |
Patrick Guye |
title |
Genetically engineering self-organization of human pluripotent stem cells into a liver bud-like tissue using Gata6 |
title_short |
Genetically engineering self-organization of human pluripotent stem cells into a liver bud-like tissue using Gata6 |
title_full |
Genetically engineering self-organization of human pluripotent stem cells into a liver bud-like tissue using Gata6 |
title_fullStr |
Genetically engineering self-organization of human pluripotent stem cells into a liver bud-like tissue using Gata6 |
title_full_unstemmed |
Genetically engineering self-organization of human pluripotent stem cells into a liver bud-like tissue using Gata6 |
title_sort |
genetically engineering self-organization of human pluripotent stem cells into a liver bud-like tissue using gata6 |
publisher |
Nature Portfolio |
publishDate |
2016 |
url |
https://doaj.org/article/9b8be1df7dff49edbe97c27e4110a2e7 |
work_keys_str_mv |
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1718383230927765504 |