Genetically engineering self-organization of human pluripotent stem cells into a liver bud-like tissue using Gata6

There has been limited success in generating tissues from human induced pluripotent stem cells (hiPSCs). Here, the authors genetically engineer expression of the transcription factor Gata6 in a single isogenic hiPSC population resulting in complex tissue structures that exhibit liver bud-like proper...

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Autores principales: Patrick Guye, Mohammad R. Ebrahimkhani, Nathan Kipniss, Jeremy J. Velazquez, Eldi Schoenfeld, Samira Kiani, Linda G. Griffith, Ron Weiss
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Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/9b8be1df7dff49edbe97c27e4110a2e7
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spelling oai:doaj.org-article:9b8be1df7dff49edbe97c27e4110a2e72021-12-02T16:49:41ZGenetically engineering self-organization of human pluripotent stem cells into a liver bud-like tissue using Gata610.1038/ncomms102432041-1723https://doaj.org/article/9b8be1df7dff49edbe97c27e4110a2e72016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10243https://doaj.org/toc/2041-1723There has been limited success in generating tissues from human induced pluripotent stem cells (hiPSCs). Here, the authors genetically engineer expression of the transcription factor Gata6 in a single isogenic hiPSC population resulting in complex tissue structures that exhibit liver bud-like properties.Patrick GuyeMohammad R. EbrahimkhaniNathan KipnissJeremy J. VelazquezEldi SchoenfeldSamira KianiLinda G. GriffithRon WeissNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Patrick Guye
Mohammad R. Ebrahimkhani
Nathan Kipniss
Jeremy J. Velazquez
Eldi Schoenfeld
Samira Kiani
Linda G. Griffith
Ron Weiss
Genetically engineering self-organization of human pluripotent stem cells into a liver bud-like tissue using Gata6
description There has been limited success in generating tissues from human induced pluripotent stem cells (hiPSCs). Here, the authors genetically engineer expression of the transcription factor Gata6 in a single isogenic hiPSC population resulting in complex tissue structures that exhibit liver bud-like properties.
format article
author Patrick Guye
Mohammad R. Ebrahimkhani
Nathan Kipniss
Jeremy J. Velazquez
Eldi Schoenfeld
Samira Kiani
Linda G. Griffith
Ron Weiss
author_facet Patrick Guye
Mohammad R. Ebrahimkhani
Nathan Kipniss
Jeremy J. Velazquez
Eldi Schoenfeld
Samira Kiani
Linda G. Griffith
Ron Weiss
author_sort Patrick Guye
title Genetically engineering self-organization of human pluripotent stem cells into a liver bud-like tissue using Gata6
title_short Genetically engineering self-organization of human pluripotent stem cells into a liver bud-like tissue using Gata6
title_full Genetically engineering self-organization of human pluripotent stem cells into a liver bud-like tissue using Gata6
title_fullStr Genetically engineering self-organization of human pluripotent stem cells into a liver bud-like tissue using Gata6
title_full_unstemmed Genetically engineering self-organization of human pluripotent stem cells into a liver bud-like tissue using Gata6
title_sort genetically engineering self-organization of human pluripotent stem cells into a liver bud-like tissue using gata6
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/9b8be1df7dff49edbe97c27e4110a2e7
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